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Tuberculosis Drug Discovery and Development (GRS)
Gordon Research Seminar

From Bench to Bedside: Improving Tuberculosis Treatments from Discovery to the Clinic

Dates

June 24-25, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Joe Buonomo & Bryan Berube

Meeting Description

The Gordon Research Seminar on Tuberculosis Drug Discovery and Development is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to cover all aspects of TB drug development from bench to bedside: Identification of new drug targets, the development of new techniques to identify new drugs and screen for new drug targets, results from pre-clinical evaluation, and the clinical outcome of new drug and new combination therapies fighting Mycobacterium tuberculosis and its resistant forms.

Related Meeting

This GRS was held in conjunction with the "Tuberculosis Drug Discovery and Development" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: The Changing Face of TB Drug Discovery
Discussion Leaders: Luiz Pedro Carvalho (Francis Crick Institute, United Kingdom) and Magdalena Bielecka (University of Southampton, United Kingdom)
3:15 pm - 3:45 pmStewart Cole (Ecole Polytechnique Federale de Lausanne - EPFL, Switzerland)
"The Changing Face of TB Drug Discovery"
3:45 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmEvaluating Mechanisms of Resistance and Overcoming Them
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and modulate factors that confer drug resistance.
Discussion Leaders: Anthony Baughn (University of Minnesota, USA) and Vinayak Singh (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)
5:30 pm - 5:50 pmPooja Gopal (National University of Singapore, Singapore)
"From Mechanisms of Resistance to a Mechanism of Action for Pyrazinoic Acid and Its Prodrug Pyrazinamide"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmAbrar Abidi (Institute for Systems Biology, USA)
"The Program of Gene Transcription for the Hypoxia and Reaeration Response in MTB"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmSarah Scarry (University of North Carolina at Chapel Hill, USA)
"Strained Amine Heterocycles as Non-Hydrolyzable β-Lactam Surrogates: Mechanistic and Structure-Activity Probes for Mycobacterium tuberculosis"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmDirk Lamprecht (Africa Health Research Institute, South Africa)
"Synergistic Targeting of Mycobacterium tuberculosis Energy Metabolism"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amIdentification and Evaluation of Novel Drug Targets
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and exploit novel drug targets.
Discussion Leaders: Mary Jackson (Colorado State University, USA) and Erik Hasenoehrl (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 amSamantha Wellington (Harvard University, USA)
"Identification of a Specific, Allosteric Small-Molecule Inhibitor of Mycobacterium tuberculosis Tryptophan Synthase"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amShuyi Ma (Center for Infectious Disease Research, USA)
"Data-Driven Inference of Drug Synergy"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amEachan Johnson (Broad Institute of MIT and Harvard, USA)
"A New Platform for Anti-Tubercular Drug Discovery"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amMonica Campo (University of Washington, USA)
"HDAC 1, 2, 3 Inhibitor as a Host Directed Therapy Against Mycobacterium tuberculosis Infection"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmTranslation from the Benchtop to the Bedside: Identifying and Combating Mtb in the Community
Translational research towards identifying novel diagnostic tools, vaccines, and getting new therapies into humans.
Discussion Leaders: Laura Via (National Institute of Allergy and Infectious Diseases, NIH, USA) and Jinghang Xie (Stanford University School of Medicine, USA)
1:30 pm - 1:50 pmMireille Kamariza (Stanford University, USA)
"Detection of Live Mycobacteria with a Solvatochromic Trehalose Probe for Point-of-Care Tuberculosis Diagnosis"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmChandrani Thakur (Indian Institute of Science Bangalore, India)
"Unbiased Identification of Blood-Based Biomarkers for Prognosis of Treatment in Tuberculosis Patients"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible [in part] by 1 R13 AI 131575 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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