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Tuberculosis Drug Discovery & Development (GRS)
Gordon Research Seminar

From Bench to Bedside: Improving Tuberculosis Treatments from Discovery to the Clinic

Dates

June 24-25, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy Site Information

Organizers

Chairs:
Joe Buonomo & Bryan Berube

Application Deadline

Applications for this meeting must be submitted by May 27, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by March 24, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description

Overview

The Gordon Research Seminar on Tuberculosis Drug Discovery and Development is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to cover all aspects of TB drug development from bench to bedside: Identification of new drug targets, the development of new techniques to identify new drugs and screen for new drug targets, results from pre-clinical evaluation, and the clinical outcome of new drug and new combination therapies fighting Mycobacterium tuberculosis and its resistant forms.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by March 24, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Tuberculosis Drug Discovery & Development" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Opportunities and Challenges in TB Drug Discovery
Discussion Leaders: Luiz Pedro Carvalho (Francis Crick Institute, United Kingdom) and Joanna Evans (University of Cape Town, South Africa)
3:15 pm - 3:45 pmStewart Cole (École Polytechnique Fédérale de Lausanne (EPFL), Switzerland)
"Opportunities and Challenges in TB Drug Discovery"
3:45 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmEvaluating Mechanisms of Resistance and Overcoming Them
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and modulate factors that confer drug resistance.
Discussion Leaders: Anthony Baughn (University of Minnesota, USA) and Vinayak Singh (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)
5:30 pm - 5:50 pmPooja Gopal (National University of Singapore, Singapore)
"The Multiple Resistance Mechanisms of Pyrazinoic Acid and Its Prodrug Pyrazinamide In-Vitro and In-Vivo"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmAbrar Abidi (Institute for Systems Biology, USA)
"The Program of Gene Transcription for the Hypoxia and Reaeration Response in MTB"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmSarah Scarry (University of North Carolina at Chapel Hill, USA)
"Strained Amine Heterocycles as Non-Hydrolyzable β-Lactam Surrogates: Mechanistic and Structure-Activity Probes for Mycobacterium tuberculosis"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmDirk Lamprecht (Africa Health Research Institute, South Africa)
"Synergistic Targeting of Mycobacterium tuberculosis Energy Metabolism"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amIdentification and Evaluation of Novel Drug Targets
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and exploit novel drug targets.
Discussion Leaders: Mary Jackson (Colorado State University, USA) and Erik Hasenoehrl (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 amSamantha Wellington (Harvard University, USA)
"Identification of a Specific, Allosteric Small-Molecule Inhibitor of Mycobacterium tuberculosis Tryptophan Synthase"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amShuyi Ma (Center for Infectious Disease Research, USA)
"Data-Driven Inference of Drug Synergy"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amEachan Johnson (Broad Institute of MIT and Harvard, USA)
"A New Platform for Anti-Tubercular Drug Discovery"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amMonica Campo (University of Washington, USA)
"HDAC 1, 2, 3 Inhibitor as a Host Directed Therapy Against Mycobacterium tuberculosis Infection"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmTranslation from the Benchtop to the Bedside: Identifying and Combating Mtb in the Community
Translational research towards identifying novel diagnostic tools, vaccines, and getting new therapies into humans.
Discussion Leaders: Laura Via (National Institute of Allergy and Infectious Diseases, NIH, USA) and Jinghang Xie (Stanford University School of Medicine, USA)
1:30 pm - 1:45 pmMireille Kamariza (Stanford University, USA)
"Detection of Live Mycobacteria with a Solvatochromic Trehalose Probe for Point-of-Care Tuberculosis Diagnosis"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmChandrani Thakur (Indian Institute of Science Bangalore, India)
"Unbiased Identification of Blood-Based Biomarkers for Prognosis of Treatment in Tuberculosis Patients"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmMagdalena Bielecka (University of Southampton, United Kingdom)
"A Bioengineered 3-Dimensional Cell Culture Platform for Developing Novel Therapeutic Approaches for Tuberculosis"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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