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Bones & Teeth
Gordon Research Conference

Translating Local Tissue Interactions and Systemic Interplays into New Therapies for Bones and Teeth

Dates

February 14-19, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Maurizio Pacifici

Vice Chair:
Fanxin Long

Meeting Description

Musculoskeletal and mineralized tissue conditions including osteoporosis, bone cancer, dental and peridontal disease, deficient fracture repair, dysplasias and malformations remain health-care challenges and significant contributors to morbidity and mortality worldwide. Happily, the last few years have produced important and far-reaching discoveries, identifying new local and systemic regulatory interactions, interplays and circuits, unearthing new roles for tissue constituents, and providing a better understanding of the complex biology and physiology of bones and teeth. These discoveries have also produced opportunities for identification of disease mechanisms and targets and testing of promising therapeutics. In keeping with its role as the leading venue for communication of break-through discoveries, the GRC on Bones and Teeth will fully engage with these exciting discoveries, will provide a timely forum for their presentation, appreciation, analysis, and discussion, and will inspire and stimulate progress toward more effective and targeted therapeutics for both common and rare diseases. As such, the theme of the 2016 Conference is "From scientific discoveries to novel therapies - new horizons for bones and teeth". The overarching goal is to provide the attendees - and the young attendees in particular - with a broader prospective and encompassing understanding of bones and teeth, including how these essential structures rely on local regulators but are also enmeshed in the overall physiology of the body and how the resulting information is propelling advances in both basic and translational medicine. The Conference will bring together senior and junior scientists and clinician-scientists at the forefront of research in molecular, developmental and cell biology, genetics, systemic and organ biology, tissue repair and regeneration, and therapeutics. It will provide a unique and unmatched forum for presentation of published and unpublished data, will promote open and unfettered communication, interaction and networking, and will bring to the fore emerging research subfields, identifying research needs and opportunities.

A limited number of bursary funds are available to offset registration and travel costs for students and postdocs. We encourage all qualified and interested junior scientists to apply, regardless of gender, race, or age. If costs are a hindrance, please make an informal enquiry with the Chairs after application and/or registration.

Related Meeting

This GRC was held in conjunction with the "Bones & Teeth" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmProgenitors in Bone Development and Repair
Discussion Leader: Henry Kronenberg (Massachusetts General Hospital, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmChrista Maes (KU Leuven, Belgium)
"Mechanisms Regulating the Destination of Progenitor Cells in Bone Development and Repair"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmVicki Rosen (Harvard School of Dental Medicine, USA)
"Mechanisms of Cortical Bone Growth"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDeneen Wellik (University of Michigan Health System, USA)
"Hox Genes in Skeletal Development and Repair"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBone Marrow Constituents and Skeletal Growth
Discussion Leader: Pamela Robey (National Institute of Dental and Craniofacial Research, CSDB, NIH, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amRalf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Molecular Coupling of Bone Angiogenesis and Osteogenesis"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amLaurie McCauley (University of Michigan, USA)
"Macrophages: Big Eaters with a Big Role in Bone"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amSelected from Poster Abstracts: Stavros Manolagas (University of Arkansas for Medical Sciences, USA)
"The Quest of Estrogen Target Genes in Bone: A 2016 Update"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amThomas Clemens (Johns Hopkins University, USA)
"Role of Sensory Nerves in Bone"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmClifford Rosen (Maine Medical Center Research Institute, USA)
"Bone Marrow Adipocytes: Fat, Bone, or Other?"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Kenn Holmbeck (National Institute of Dental and Craniofacial Research, NIH, USA)
"MT1-MMP-Mediated Proteolysis in Osteogenic Cells Is Essential for Retention of Multi Potent Bone Marrow Stromal Stem/Progenitors and Attenuation of Adipogenic Differentiation Through DLK1-Shedding"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Deneen Wellik (University of Michigan Health System, USA) and Vicki Rosen (Harvard School of Dental Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDynamics of Osteocytes and Osteoblasts
Discussion Leader: Lynda Bonewald (University of Missouri-Kansas City, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmSarah Dallas (University of Missouri-Kansas City, USA)
"Cross Talk Between Osteocyte Cell Processes and Marrow"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmMitch Schaffler (City College of New York, USA)
"Osteocyte Stimulus-Perception and Regulation of Bone Repair"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Marilina Piemontese (University of Arkansas for Medical Sciences, USA)
"Glucocorticoid Action in Osteoblast-Lineage Cells Is Required for Attainment of Normal Bone Mass but Also for the Cortical Bone Loss Caused by Glucocorticoid Excess"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Nunzia Di Maggio (University of Basel, Switzerland)
"Short-Term Delivery of VEGF Protein for Vascularized Engineered Bone"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegeneration of the Dentition
Discussion Leader: Ophir Klein (University of California, San Francisco, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amPascal Schneider (University of Lausanne, Switzerland)
"Pharmacological Manipulation of the EDA-EDAR Pathway"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSamuel Stupp (Northwestern University, USA)
"Bioactive Supramolecular Biomaterials for Bone and Enamel Regeneration"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amSelected from Poster Abstracts: Bernhard Ganss (University of Toronto, Canada)
"From Enamel Maturation to Dentogingival Attachment: Novel Proteins and Potential Therapeutic Targets"
10:30 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:25 amJukka Jernvall (University of Helsinki, Finland)
"Engineering Mouse Teeth"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmJeffrey Streelman (Georgia Institute of Technology, USA)
"Plasticity of Epithelial Stem Cells in Tooth and Taste Bud Regeneration"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Masaki Honda (Aichi-Gakuin University School of Dentistry, Japan)
"Human iPS Cells Are Capable of Differentiating into Ameloblasts, Odontoblasts, and Cementocytes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOsteoclasts in Bone and Joint Health and Disease
Discussion Leader: Vicki Rosen (Harvard School of Dental Medicine, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmXu Cao (Johns Hopkins University, USA)
"Subchondral Bone and Osteoarthritis"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmYousef Abu-Amer (Washington University School of Medicine, USA)
"Inflammatory Osteolysis in Bone and Joint Diseases"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Kent Soee (Vejle Hospital / University of Southern Denmark, Denmark)
"Pit- and Trench-Forming Osteoclasts: A Distinction that Matters"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Yi-Ping Li (University of Alabama at Birmingham, USA)
"G Protein Alpha 13 Signaling to Inhibit Osteoclast Activation and Function"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRare Musculoskeletal Diseases and Possible Therapies
Discussion Leader: Kevin Jones (University of Utah, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBrendan Lee (Baylor College of Medicine, USA)
"Osteogenesis Imperfecta: Novel Treatment Targets and Options"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amJacqueline Hecht (The University of Texas Health Science Center, USA)
"Therapeutic Strategies for Pseudoachondroplasia"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amSelected from Poster Abstracts: Tatiana Besschetnova (Harvard School of Dental Medicine, USA)
"Mouse Model of GAPO Syndrome: ANTXR1-Dependent Maintenance of Balance Between Mesenchymal Stem Cell Renewal and Differentiation"
10:30 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amAris Economides (Regeneron Pharmaceuticals, Inc., USA)
"Modeling FOP in the Mouse Reveals the Molecular Pathophysiology of the Disease and Provides New Paths to Therapy"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Katherine Motyl (Maine Medical Center, USA)
"Hyperprolactinemia-Induced Hypogonadism Does Not Explain Bone Loss from the Atypical Antipsychotic Risperidone"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmSelected from Poster Abstracts: Marie Wehenkel (St. Jude Children's Research Hospital, USA)
"Chondrocyte-Autonomous Dysregulation of Erk Signaling Leads to the Development of Chondromatosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmAdult Stem Cells and Dental Repair
Discussion Leader: Yang Chai (University of Southern California, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmOphir Klein (University of California, San Francisco, USA)
"Mechanoregulation of Tooth Stem Cells"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmFrederic Michon (University of Helsinki, Finland)
"Incisors and Cornea: Comparative Study of Stem Cells and Renewal Strategies"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: Amnon Sharir (University of California, San Francisco, USA)
"Revisiting the Role of Mouse Incisor Stem Cells in Maintenance and Repair"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSelected from Poster Abstracts: Emi Shimizu (New York University College of Dentistry, USA)
"The Role of EphrinB1 in the Repair Process of Dentin"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular and Systemic Regulators of Bone Biology
Discussion Leader: Steven Teitelbaum (Washington University School of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amFanxin Long (Washington University Medical School, USA)
"Glucose Metabolism and Bone Formation"
9:35 am - 9:45 amDiscussion
9:45 am - 10:00 amSelected from Poster Abstracts: Mathieu Ferron (Institut de Recherches Cliniques de Montréal, Canada)
"Novel Role of Vitamin K-Dependent Gamma-Carboxylation in Bone Remodeling"
10:00 am - 10:05 amDiscussion
10:05 am - 10:20 amSelected from Poster Abstracts: Jean-Marie Delaisse (University of Southern Denmark, Denmark)
"The Bone Marrow Envelope: A Likely Provider of Osteoprogenitors During Remodeling of Adult Human Bone"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:10 amSelected from Poster Abstracts: Veronique Lefebvre (Cleveland Clinic Lerner Research Institute, USA)
"SOX-Mediated Control of Osteogenesis"
11:10 am - 11:15 amDiscussion
11:15 am - 11:30 amSelected from Poster Abstracts: Ling Qin (University of Pennsylvania, USA)
"The Critical Role of Mesenchymal Progenitors in Initiating the Secondary Ossification Center at the Epiphyseal Cartilage"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmSteven Teitelbaum (Washington University School of Medicine, USA)
"Roles of Asxl2 in Bone Homeostasis and Energy Metabolism"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: VEGF Biology in Bone Health and Disease
Discussion Leader: Eileen Shore (University of Pennsylvania School of Medicine, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:40 pmBjorn Olsen (Harvard School of Dental Medicine, USA)
"VEGF Biology in Bone Health and Disease"
8:40 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (1 R13AR69402-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS), all co-funding received from the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute of Dental and Craniofacial Research (NIDCR). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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