Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Mesenchymal Stem Cells and Progenitors
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Growth-Associated Skeletal Progenitors"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Hox Genes and the Developmental Origin of Skeletal Mesenchymal Stem/Progenitor Cells (MSCs)"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Bi-Directional Interaction Between Mesenchymal Stem Cells and Transit Amplifying Cells in Mesenchymal Tissue Homeostasis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Molecular Regulation of Bone and Tooth Development and Homeostasis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Fibroblast Growth Factors: Critical Regulators of Osteogenic and Chondrogenic Growth Programs"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Neural Crest Cells and Their Roles in Cranioskeletal Development and the Pathogenesis of Ribosomopathies"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"CFP1 Is a Critical Regulator of Skeletal Development"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"TGF-β, Novel Roles in Tooth Development"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Nutritional Regulation of BMSC Lineage Selection and Bone Formation"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Osteogenic Commitment of Mesenchymal Progenitors and Osteoblast Maturation Requires PTPN11"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Skeletal Aging and Regeneration
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Response of Bone to Mechanical Loading – Wnts, Aging and Cell Proliferation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"The Contribution of Osteocyte Malfunction to Skeletal Aging"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Hedgehog Signaling Is Required to Generate Hybrid Cartilage-Bone Cells During Large Scale Skeletal Regeneration"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Coordinating Tissue Regeneration Through TGF-β Activated Kinase 1 (TAK1) In-Activation and Re-Activation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Macrophage Cells Secrete Factors that Orchestrate the Rejuvenation of Bone Repair"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Basis for Rare Bone Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva (FOP)"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Crossover Mineral Metabolism: Revealing Novel Control of FGF23"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Experimental Models of Hajdu Cheney Syndrome and Related Disorders"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Aberrant Protein Signaling Drives Osteochondroma Formation in Hereditary Multiple Exostoses"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Loss of SIK3 Kinase Activity Impairs Degradation of the mTOR Inhibitor DEPTOR and Leads to Abnormalities in Skeletal and Immunological Development"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Genetic Interactions Between PDGFRb and the STAT1 Pathway in Rare Bone Diseases"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular and Molecular Cross-Talk in Bones and Teeth
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Molecular Patterning of the Hard Palate"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"The Modular Model for Long Bone Morphogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Identifying Factors that Regulate Periosteal Growth"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"TGF-Beta Signaling Is Sufficient to Prevent Loss of Tendon Cell Fate in a Cell-Autonomous Manner"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Induced GnasR201H Expression from the Endogenous Gnas locus Causes Fibrous Dysplasia by Upregulating Wnt/β-Catenin Signaling"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Regulation of the Skeleton
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Choke to Start the Engine: How Impairment of Mitochondrial Function Can Improve Survival of Hypoxic Cells In Vivo "
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Metabolism, Chondrocytes, and Osteoarthritis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Glucose and Glutamine for Skeletal Cell Survival and Matrix Properties"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Fatty Acid Utilization by Bone"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Proprotein Convertase Furin Is a Novel Pleiotropic Regulator of Bone Endocrine Functions"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Glutamine Metabolism Is Required for the Maintenance and Specification of Mesenchymal Stem Cells"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Degenerative Joint Diseases and Emerging Therapies
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Elucidating the NOTCH/HES1/IL-6 Signaling Axis in Osteoarthritis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Application of iPS Cell Technologies to the Research of Cartilage Diseases"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Subchondral Bone Plate Sclerosis During Late Osteoarthritis Is Caused by Loading-Induced Reduction in Sclerostin"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"mTORC1 Signaling in Mutant Cartilage Oligomeric Matrix Protein (COMP) Pathology - Potential Novel Therapeutic Target"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Loss of Fkbp10 in Murine Tendon Induces Postnatal Joint Contractures and Reduced Collagen Cross-Linking"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Integrative Physiology of the Skeleton
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"From the Osteoclast to Obesity Prevention"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The Role of the Bone Marrow Adipocyte in Energy Homeostasis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Cancer, Bone, Muscle and Metabolism: What's the Connection?"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Bone Morphogenetic Protein-6 Regulates Type 1 Diabetes Mellitus-Associated Bone Loss"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Lysyl Oxidase Regulation Is a Critical Determinant of Diabetic Osteopenia"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targeting Key Signaling Pathways for Therapy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Wnt Signaling in Skeletal Development and Homeostasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Targeting the Wnt Pathway for Therapeutic Benefits in Bone and Teeth"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Characterization of Blocking Antibodies Against ALK2, Which Is a BMP Type I Receptor Associated with FOP"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Targeting Signaling Pathways in Osteoblasts as a Treatment for Myelodysplasia and Acute Myeloid Leukemia"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Inhibiting the Integrated Stress Response Prevents Aberrant Chondrocyte Differentiation and Alleviates Skeletal Defects in Chondrodysplasia"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure