| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Mesenchymal Stem Cells in Bone Tissue Homeostasis and
Repair |
| Discussion Leader: Maurizio Pacifici (Children's Hospital of Philadelphia, USA) |
| 3:45 pm - 4:20 pm | Yang Chai (University of Southern California, USA)
"Mesenchymal Stem Cells in Bone Tissue Homeostasis and Repair" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mechanisms
of Bone Development and Regeneration |
| Discussion Leaders: Brendan Lee (Baylor College of Medicine, USA) and Federica Sgariglia (Children's Hospital of Philadelphia, USA) |
| 7:30 pm - 7:45 pm | Shailesh Agarwal (University of Michigan, USA)
"Loss of HIF1a Eliminates Heterotopic Ossification by Mediating Mesenchymal Condensation" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Erin Ealba (University of Michigan, USA)
"Tgf-β Signaling in Neural Crest Mesenchyme Affects Mandibular Bone Development and Resorption" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Hongjiao Ouyang (University of Pittsburgh, USA)
"ER Stress Signaling Transducer IRE1a Links ER Stress to Canonical Wnt
Signaling in Regulating Postnatal Bone Development and Homeostasis" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Danielle Rux (University of Michigan, USA)
"A Role for Hox11-Expressing Mesenchymal Stem/Stromal Cells in Bone Remodeling" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Nanditha Das (Regeneron, USA)
"Heterotopic Ossification in a Mouse Model of FOP Induces Extensive Remodeling of the Existing Bone During Integration with the Skeleton" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Megan Michalski (University of Michigan School of Dentistry, USA)
"MFG-E8 Mutant Mice Exhibit Reduced Bone Mass and Enhanced Anabolic Response to Parathyroid Hormone" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Skeletal Stem Cells and Their Niches |
| Discussion Leaders: Fanxin Long (Washington University Medical School, USA) and Alexandra Stanley (University of Pennsylvania, USA) |
| 9:00 am - 9:15 am | Danielle Bonfim (National Institute of Dental and Craniofacial Research, NIH, USA)
"Atrophic Nonunion Tissue Contains Stromal Cells with Potential to Perform Ossification In Vitro and In Vivo" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Julia Etich (University of Cologne, Germany)
"The Role of CD200 and CD200-Mediated Cell-Matrix Interactions for Skeletal Homeostasis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Marina Feigenson (Mayo Clinic, USA)
"Histone Deacetylase 3 Inhibits Mesenchymal Stromal Cell Adipogenic Differentiation" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Thomas Imhof (University of Cologne, Germany)
"The Role of Tenascin N in Continuously Erupting Rodent Incisors" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Seyedmohammad Tahaei (Baylor College of Medicine, USA)
"Skeletal Maladies in Neurofibromatosis Type 1: RASopathy or Not?" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Jennifer Zieba (University of California, Los Angeles, USA)
"Effect of Filamin B on TGF-β/BMP Signaling Induces Disc Degeneration and Vertebral Fusions in Spondylocarpotarsal Synostosis Murine Model" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Translational Aspects of Bone Tissue Repair |
| Discussion Leaders: Marie Wehenkel (St. Jude Children's Research Hospital, USA) and Shai Eyal (Weizmann Institute of Science, Israel) |
| 1:30 pm - 1:45 pm | Rebecca Watters (University of Pittsburgh, USA)
"A Novel Mouse Model Demonstrates that a SNP in Steroid Receptor Co-Activator-1 Alters Bone Cell Phenotypes" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Yi-chien Lee (Baylor College of Medicine, USA)
"Sclerostin Antibody (Scl-Ab) Increased Bone Mass and Strength in a Mouse Model of Osteogenesis Imperfecta Caused by Wnt1 Mutation" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Abhishek Chandra (University of Pennsylvania, USA)
"Suppression of Sclerostin Alters and Protects the Fate of Mesenchymal Progenitors to Alleviate the Radiation Induced Osteoporosis" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
