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Bones & Teeth (GRS)
Gordon Research Seminar

Building on Solid Foundations: From Mechanisms to Bone Tissue Repair

Dates

February 13-14, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Nunzia Di Maggio & Shai Eyal

Meeting Description

The Gordon Research Seminar on Bones and Teeth is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Despite the rapid advancements in our understanding of mechanisms involved in bones and teeth development and regeneration, our ability to translate this knowledge into the clinic is still largely lacking. The aim of this meeting is to present the latest discoveries in both basic and translational research, in order to give students and young scientists a perspective on how these two approaches can feed on each other and move into novel therapeutic solutions. Topics of interest include, but are not limited to, mechanisms of bone development and regeneration, skeletal stem cells and their niches and translational aspects of bone tissue repair.

Related Meeting

This GRS was held in conjunction with the "Bones & Teeth" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Mesenchymal Stem Cells in Bone Tissue Homeostasis and Repair
Discussion Leader: Maurizio Pacifici (Children's Hospital of Philadelphia, USA)
3:45 pm - 4:20 pmYang Chai (University of Southern California, USA)
"Mesenchymal Stem Cells in Bone Tissue Homeostasis and Repair"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Bone Development and Regeneration
Discussion Leaders: Brendan Lee (Baylor College of Medicine, USA) and Federica Sgariglia (Children's Hospital of Philadelphia, USA)
7:30 pm - 7:45 pmShailesh Agarwal (University of Michigan, USA)
"Loss of HIF1a Eliminates Heterotopic Ossification by Mediating Mesenchymal Condensation"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmErin Ealba (University of Michigan, USA)
"Tgf-β Signaling in Neural Crest Mesenchyme Affects Mandibular Bone Development and Resorption"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmHongjiao Ouyang (University of Pittsburgh, USA)
"ER Stress Signaling Transducer IRE1a Links ER Stress to Canonical Wnt Signaling in Regulating Postnatal Bone Development and Homeostasis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmDanielle Rux (University of Michigan, USA)
"A Role for Hox11-Expressing Mesenchymal Stem/Stromal Cells in Bone Remodeling"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmNanditha Das (Regeneron, USA)
"Heterotopic Ossification in a Mouse Model of FOP Induces Extensive Remodeling of the Existing Bone During Integration with the Skeleton"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMegan Michalski (University of Michigan School of Dentistry, USA)
"MFG-E8 Mutant Mice Exhibit Reduced Bone Mass and Enhanced Anabolic Response to Parathyroid Hormone"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amSkeletal Stem Cells and Their Niches
Discussion Leaders: Fanxin Long (Washington University Medical School, USA) and Alexandra Stanley (University of Pennsylvania, USA)
9:00 am - 9:15 amDanielle Bonfim (National Institute of Dental and Craniofacial Research, NIH, USA)
"Atrophic Nonunion Tissue Contains Stromal Cells with Potential to Perform Ossification In Vitro and In Vivo"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amJulia Etich (University of Cologne, Germany)
"The Role of CD200 and CD200-Mediated Cell-Matrix Interactions for Skeletal Homeostasis"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMarina Feigenson (Mayo Clinic, USA)
"Histone Deacetylase 3 Inhibits Mesenchymal Stromal Cell Adipogenic Differentiation"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amThomas Imhof (University of Cologne, Germany)
"The Role of Tenascin N in Continuously Erupting Rodent Incisors"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSeyedmohammad Tahaei (Baylor College of Medicine, USA)
"Skeletal Maladies in Neurofibromatosis Type 1: RASopathy or Not?"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amJennifer Zieba (University of California, Los Angeles, USA)
"Effect of Filamin B on TGF-β/BMP Signaling Induces Disc Degeneration and Vertebral Fusions in Spondylocarpotarsal Synostosis Murine Model"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmTranslational Aspects of Bone Tissue Repair
Discussion Leaders: Marie Wehenkel (St. Jude Children's Research Hospital, USA) and Shai Eyal (Weizmann Institute of Science, Israel)
1:30 pm - 1:45 pmRebecca Watters (University of Pittsburgh, USA)
"A Novel Mouse Model Demonstrates that a SNP in Steroid Receptor Co-Activator-1 Alters Bone Cell Phenotypes"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmYi-chien Lee (Baylor College of Medicine, USA)
"Sclerostin Antibody (Scl-Ab) Increased Bone Mass and Strength in a Mouse Model of Osteogenesis Imperfecta Caused by Wnt1 Mutation"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmAbhishek Chandra (University of Pennsylvania, USA)
"Suppression of Sclerostin Alters and Protects the Fate of Mesenchymal Progenitors to Alleviate the Radiation Induced Osteoporosis"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by (1 R13AR69402-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS), all co-funding received from the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute of Dental and Craniofacial Research (NIDCR). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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