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Molecular Mechanisms in Evolution
Gordon Research Conference

Combining Evolutionary and Molecular Biology to Understand Emergence and Fate of Biological Systems

Dates

June 11-16, 2017

Location

Stonehill College
Easton, MA

Organizers

Chair:
Ivan Matic

Vice Chair:
Andrew W. Murray

Meeting Description

The 2017 Gordon Conference on Molecular Mechanisms in Evolution will bring together leading experts in molecular, medical and evolutionary biology to present the latest findings and diverse perspectives on the molecular bases of evolutionary change. Understanding evolutionary processes lays the foundation for comprehending the history of life on earth and of the mechanisms that produce its unity and diversity. Therefore it is fundamental to all aspects of biology. But it is also pivotal for designing efficient strategies to deal with important human health issues like the evolution of virulence, the emergence of drug resistance and the progression of cancer. The scientific program of the conference will be divided in sessions covering a wide range of topics including: origins of life, evolution of mutation and recombination rates, stress-inducible genetic variation, non-genetic variation and inheritance, phenotypic noise, evolution of novelty, evolution of complexity, cancer, aging, experimental evolution and evolutionary contingency. The main objective of this GRC is to encourage and nurture a community of researchers, across traditional disciplinary boundaries, with a shared interest in the molecular bases of evolutionary change. This is of greatest importance: without such a community researchers may be unaware of the important recent discoveries and cutting-edge technological developments outside their respective scientific fields. This conference aims to create an engaging atmosphere for open and creative discussions in order to stimulate collaborations among scientists. We will also provide opportunities for junior scientists and graduate students to present their work in poster format, or in short invited talks, and exchange ideas with researchers who are at the forefront of their fields.

Related Meeting

This GRC was held in conjunction with the "Molecular Mechanisms in Evolution" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Origin of Life, Evolution and Aging
Discussion Leader: Ivan Matic (INSERM U1001 / Universite Paris Descartes, France)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmNigel Goldenfeld (University of Illinois, USA)
"Evolutionary Transitions in the First 1,000,000,000 Years of Life: Emergence of Homochirality and the Genetic Code"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmTom Kirkwood (Institute for Ageing, Newcastle University, United Kingdom)
"Evolution and the Origins of Aging"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSetting Evolutionary Rates: Mutation and Recombination
Discussion Leader: Olivier Tenaillon (INSERM, France)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amDaniel Fisher (Stanford University, USA)
"How Much Recombination Is Enough?"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amLaurent Duret (University of Lyon, CNRS, France)
"Biased Gene Conversion: The Dark Side of Recombination"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amKirsten Bomblies (John Innes Centre, United Kingdom)
"Causes and Consequences of the Evolution of Meiosis and Recombination"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amJohan Paulsson (Harvard University, USA)
"Fluctuations and Control of Macromolecules in Bacteria"
11:25 am - 11:35 amDiscussion
11:35 am - 11:45 amSelected from Poster Abstracts: Marina Elez (Pierre and Marie Curie University, France)
"Mutation Dynamics and Fitness Effects Followed in Single Cells"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmSelected from Poster Abstracts: Lana Talmane (The University of Edinburgh, United Kingdom)
"The Landscape of Replication-Associated Mutations in Human and Mouse Germlines"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Chi Xue (University of Illinois at Urbana-Champaign, USA)
"Even Parasites Have Parasites: Oscillatory Population Dynamics of Mobile Genetic Elements in Your Genome"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Susan Rosenberg (Baylor College of Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStress-Inducible Genetic Variation and Evolution
Discussion Leader: Susan Rosenberg (Baylor College of Medicine, USA)
7:30 pm - 7:50 pmTom Kuhlman (University of Illinois, USA)
"Real Time Transposable Element Activity in Live Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmThomas Ferenci (University of Sydney, Australia)
"Non-Linearity Between Inputs and Outputs in Stress-Induced Mutagenesis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJudith Berman (Tel Aviv University, Israel)
"Eukaryotic Mechanisms of Overcoming Antimicrobial Drug Stress"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmReuben Harris (Howard Hughes Medical Institute, USA)
"Tumor Evolution by APOBEC-Catalyzed DNA Deamination"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-Genetic Variation and Inheritance
Discussion Leader: Martin Ackermann (ETH Zurich, Switzerland)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amAndreas Wagner (University of Zurich, Switzerland)
"On the Role of Mistranslation in Adaptive Evolution"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amRaul Andino (University of California, San Francisco, USA)
"Genome Variation, Population Size and Selection During RNA Virus Infection"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amChristophe Herman (Baylor College of Medicine, USA)
"Transcription Fidelity Impedes DNA Break Repair"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amSelected from Poster Abstracts: Lilach Hadany (Tel Aviv University, Israel)
"Non-Genetic Inheritance and the Evolution of Cooperation"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amSelected from Poster Abstracts: Dragan Stajic (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciencia, Portugal)
"The Role of Epigenetic Mechanisms in the Adaptive Evolution"
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amSelected from Poster Abstracts: Naomi Ziv (University of California, San Francisco, USA)
"Molecular Analysis of Bistability in a Eukaryotic Transcriptional Network"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmSelected from Poster Abstracts: Xinzhu Wei (University of Michigan, USA)
"A New Theory on the Cause of Genetic Dominance"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Lei Sun (ETH Zurich, Switzerland)
"Effective Polyploidy Causes Phenotypic Delay and Influences Bacterial Evolvability"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPhenotypic Noise and Evolution
Discussion Leader: Christophe Herman (Baylor College of Medicine, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmMartin Ackermann (ETH Zurich, Switzerland)
"An Evolutionary Perspective on Phenotypic Heterogeneity in Microbes"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmLeor Weinberger (University of California, San Francisco, USA)
"Adaptations for Harnessing 'Noise' to Control Fate Specification"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Angela Phillips (Massachusetts Institute of Technology, USA)
"Influenza Evolution Is Modulated by Host Proteostasis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmSelected from Poster Abstracts: Joel Stavans (Weizmann Institute of Science, Israel)
"One Day in the Life, Development and Evolution of a One-Dimensional Organism"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmSelected from Poster Abstracts: Zoran Marinkovic (Paris Diderot University, France)
"Growth, Differentiation and Self-Organization of S. cerevisiae Colonies in Controlled Spatially Structured Dynamically Changing Environments"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolution of Novelty
Discussion Leader: Joe Thornton (University of Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amManyuan Long (University of Chicago, USA)
"The Sibling Paradox: Rapid Evolution of Genetic Systems for Phenotypic Control by New Genes"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amShelley Copley (University of Colorado Boulder, USA)
"Promiscuity, Serendipity and Metabolic Innovation"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amMarie-Anne Felix (Institut de Biologie de l'Ecole Normale Superieure, France)
"Phenotypic Effects of Random Mutation"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amSelected from Poster Abstracts: Avihu Yona (Massachusetts Institute of Technology, USA)
"Random Sequences Rapidly Evolve into De Novo Promoters"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amSelected from Poster Abstracts: Victor Luria (Harvard Medical School, USA)
"Variation and Novelty in Evolution: De Novo Genes Arise and Enable Protein Structural Innovation"
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amSelected from Poster Abstracts: Debora Marks (Harvard Medical School, USA)
"Evolutionary Couplings from Sequences: Prediction of 3D Structure and Fitness"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmSelected from Poster Abstracts: Krishna Swamy (Institute of Molecular Biology, Academia Sinica, Taiwan)
"Proteatoxic Stress Due to Loss of Interaction Partners Induces Reproductive Isolation in Yeast Hybrids"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Yu-Ying Hsieh (Harvard University, USA)
"Repurposing the Function of a Meiotic Cohesin Protein in Budding Yeast"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEvolution of Complexity
Discussion Leader: Marie-Anne Felix (Institut de Biologie de l'Ecole Normale Superieure, France)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmGunter Wagner (Yale University, USA)
"Evolving Complex Body Plans Through Cell Type Diversity: Molecular and Cellular Mechanisms"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmAnnalise Paaby (Georgia Institute of Technology, USA)
"Conditionally Functional Variation and the Evolution of Complex Traits"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmJoe Thornton (University of Chicago, USA)
"Ancient Mechanisms for the Evolution of a New Molecular Signaling System"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmSelected from Poster Abstracts: Tyler Starr (University of Chicago, USA)
"Alternative Evolutionary Histories in the Sequence Space of an Ancient Protein"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSomatic Evolution: Cancer
Discussion Leader: Darryl Shibata (Keck School of Medicine, University of Southern California, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMarco Gerlinger (The Institute of Cancer Research, United Kingdom)
"Dissecting Cancer Evolution: Patterns, Dynamics and Clinical Implications"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amRichard White (Memorial Sloan Kettering Cancer Center, USA)
"Error-Prone DNA Polymerases in Melanoma Progression and Drug Resistance"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amSusan Rosenberg (Baylor College of Medicine, USA)
"E. coli Identifies New Cancer Gene Functions that Promote Evolvability"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amSelected from Poster Abstracts: Muhammad Sufyan Bin Masroni (National University of Singapore, Singapore)
"Regenerable Altruism in Clonal Cancer Cells"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amSelected from Poster Abstracts: Cemalettin Bekpen (Max-Planck Institute for Evolutionary Biology, Germany)
"High Copy Number of SPATA31 Genes Correlates with Somatic Mutation Rate and Shorter Life Span in Humans"
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amSelected from Poster Abstracts: Joanna Masel (University of Arizona, USA)
"Intercellular Competition and the Inevitability of Multicellular Aging"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmAlesia McKeown (University of Utah School of Medicine, USA)
"Novel Roles for Retrogenes in Host Immunity"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Amir Mitchell (University of Massachusetts Medical School, USA)
"Extracellular Stimuli Dynamics Can Undermine Optimal Cell Response: Detrimental Misperception by the MAPK Signaling Network in Yeast"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmReplaying the Tape of Life: Experimental Evolution and Evolutionary Contingency
Discussion Leader: Andrew Murray (Harvard University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmOlivier Tenaillon (INSERM, France)
"The Long-Term Molecular Fate of Mutator Genomes"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmTim Cooper (University of Houston, USA)
"Gene Interactions Cause Repeatable Changes in E. coli Evolvability"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmMichael Desai (Harvard University, USA)
"The Dynamics of Molecular Evolution over 60,000 Generations"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmSelected from Poster Abstracts: Yuping Li (Stanford University, USA)
"Understanding Adaptation and Fitness Trade-Offs in Yeast"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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