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Molecular Mechanisms in Evolution
Gordon Research Conference

Combining Evolutionary and Molecular Biology to Understand Emergence and Fate of Biological Systems

Dates

June 11-16, 2017

Location

Stonehill College
Easton, MA Site Information

Organizers

Chair:
Ivan Matic

Vice Chair:
Andrew W. Murray

Application Deadline

Applications for this meeting must be submitted by May 14, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Conference on Molecular Mechanisms in Evolution will bring together leading experts in molecular, medical and evolutionary biology to present the latest findings and diverse perspectives on the molecular bases of evolutionary change. Understanding evolutionary processes lays the foundation for comprehending the history of life on earth and of the mechanisms that produce its unity and diversity. Therefore it is fundamental to all aspects of biology. But it is also pivotal for designing efficient strategies to deal with important human health issues like the evolution of virulence, the emergence of drug resistance and the progression of cancer. The scientific program of the conference will be divided in sessions covering a wide range of topics including: origins of life, evolution of mutation and recombination rates, stress-inducible genetic variation, non-genetic variation and inheritance, phenotypic noise, evolution of novelty, evolution of complexity, cancer, aging, experimental evolution and evolutionary contingency. The main objective of this GRC is to encourage and nurture a community of researchers, across traditional disciplinary boundaries, with a shared interest in the molecular bases of evolutionary change. This is of greatest importance: without such a community researchers may be unaware of the important recent discoveries and cutting-edge technological developments outside their respective scientific fields. This conference aims to create an engaging atmosphere for open and creative discussions in order to stimulate collaborations among scientists. We will also provide opportunities for junior scientists and graduate students to present their work in poster format, or in short invited talks, and exchange ideas with researchers who are at the forefront of their fields.

Related Meeting

This GRC will be held in conjunction with the "Molecular Mechanisms in Evolution" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Origin of Life, Evolution and Aging
Discussion Leader: Ivan Matic (INSERM / Université Paris Descartes, France)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmNigel Goldenfeld (University of Illinois, USA)
"Evolutionary Transitions in the First 1,000,000,000 Years of Life: Emergence of Homochirality and the Genetic Code"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmTom Kirkwood (Institute for Ageing, Newcastle University, United Kingdom)
"Evolution and the Origins of Aging"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSetting Evolutionary Rates: Mutation and Recombination
Discussion Leader: Olivier Tenaillon (INSERM, France)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMichael Lynch (Indiana University Bloomington, USA)
"Evolution of Mutation Rates at the Replication and Transcriptional Levels"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amDaniel Fisher (Stanford University, USA)
"How Much Recombination Is Enough?"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amLaurent Duret (University of Lyon, CNRS, France)
"Biased Gene Conversion: The Dark Side of Recombination"
10:55 am - 11:05 amDiscussion
11:05 am - 11:25 amKirsten Bomblies (John Innes Centre, United Kingdom)
"Causes and Consequences of the Evolution of Meiosis and Recombination"
11:25 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Susan Rosenberg (Baylor College of Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStress-Inducible Genetic Variation and Evolution
Discussion Leader: Susan Rosenberg (Baylor College of Medicine, USA)
7:30 pm - 7:50 pmTom Kuhlman (University of Illinois, USA)
"Real Time Transposable Element Activity in Live Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmThomas Ferenci (University of Sydney, Australia)
"Non-Linearity Between Inputs and Outputs in Stress-Induced Mutagenesis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJudith Berman (Tel Aviv University, Israel)
"Eukaryotic Mechanisms of Overcoming Antimicrobial Drug Stress"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmReuben Harris (Howard Hughes Medical Institute, USA)
"Tumor Evolution by APOBEC-Catalyzed DNA Deamination"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-Genetic Variation and Inheritance
Discussion Leader: Dan Tawfik (Weizmann Institute of Science, Israel)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amAndreas Wagner (University of Zurich, Switzerland)
"On the Role of Mistranslation in Adaptive Evolution"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amChristophe Herman (Baylor College of Medicine, USA)
"Transcription Fidelity Impedes DNA Break Repair"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amRaul Andino (University of California, San Francisco, USA)
"Genome Variation, Population Size and Selection During RNA Virus Infection"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amShort Talk Selected from Poster Abstracts
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPhenotypic Noise and Evolution
Discussion Leader: Edo Kussell (New York University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmMartin Ackermann (ETH Zurich, Switzerland)
"An Evolutionary Perspective on Phenotypic Heterogeneity in Microbes"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmJohan Paulsson (Harvard Medical School, USA)
"Fluctuations and Control of Macromolecules in Bacteria"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmLeor Weinberger (University of California, San Francisco, USA)
"Adaptations for Harnessing 'Noise' to Control Fate Specification"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmShort Talk Selected from Poster Abstracts
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolution of Novelty
Discussion Leader: Joe Thornton (University of Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amDan Tawfik (Weizmann Institute of Science, Israel)
"How Do Proteins Evolve"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amManyuan Long (University of Chicago, USA)
"The Sibling Paradox: Rapid Evolution of Genetic Systems for Phenotypic Control by New Genes"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amFrank Rosenzweig (University of Montana, USA)
"Sweet Are the Uses of Adversity: Genomic Responses to Stress and Their Role in Adaptation and Speciation"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amShort Talk Selected from Poster Abstracts
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEvolution of Complexity
Discussion Leader: Marie-Anne Felix (Institut de Biologie de l'Ecole Normale Superieure, France)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmGunter Wagner (Yale University, USA)
"Evolving Complex Body Plans Through Cell Type Diversity: Molecular and Cellular Mechanisms"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmAnnalise Paaby (Georgia Institute of Technology, USA)
"Conditionally Functional Variation and the Evolution of Complex Traits"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmChristine Queitsch (University of Washington, USA)
"Towards Resolving Complex Trait Architecture"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmShort Talk Selected from Poster Abstracts
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSomatic Evolution: Cancer
Discussion Leader: Darryl Shibata (Keck School of Medicine, University of Southern California, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMarco Gerlinger (The Institute of Cancer Research, United Kingdom)
"Dissecting Cancer Evolution: Patterns, Dynamics and Clinical Implications"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amRichard White (Memorial Sloan Kettering Cancer Center, USA)
"Error-Prone DNA Polymerases in Melanoma Progression and Drug Resistance"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:55 amSusan Rosenberg (Baylor College of Medicine, USA)
"E. coli Identifies New Cancer Gene Functions that Promote Evolvability"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amShort Talk Selected from Poster Abstracts
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmReplaying the Tape of Life: Experimental Evolution and Evolutionary Contingency
Discussion Leader: Andrew Murray (Harvard University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmOlivier Tenaillon (INSERM, France)
"The Long-Term Molecular Fate of Mutator Genomes"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmTim Cooper (University of Houston, USA)
"Gene Interactions Cause Repeatable Changes in E. coli Evolvability"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmMichael Desai (Harvard University, USA)
"The Dynamics of Molecular Evolution over 60,000 Generations"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmShort Talk Selected from Poster Abstracts
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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