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Pancreatic Diseases
Gordon Research Conference

Exocrine and Endocrine Pancreas: Molecules to Human

Dates

June 18-23, 2017

Location

Waterville Valley
Waterville Valley, NH Site Information

Organizers

Chair:
Diane M. Simeone

Vice Chair:
Maike Sander

Application Deadline

Applications for this meeting must be submitted by May 21, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Despite the rapid advances in our understanding of the molecular mechanisms involved in pancreatic development, regeneration, and malignant transformation, as well as our ability to model these processes in mice and recently also human cells, our ability to translate this knowledge into the clinical setting to benefit patients is still largely lacking. This relatively new GRC aims to link the understanding of the biology of the exocrine and endocrine pancreas to applications to human diseases. This GRC is unique in that it is the only conference that convenes experts from all aspects of pancreas biology as well as clinicians working on translational approaches for various pancreatic diseases, including pancreatic cancer, pancreatitis and diabetes. By providing a forum for the presentation and discussion of cutting edge, unpublished concepts and approaches, the goal of this GRC is to stimulate discussion across fields and disciplines. This exchange will foster interdisciplinary approaches in the field and promote exchange of ideas and experiences to lead to new collaborations, as well as empower young scientists to showcase their work to peers and leaders in the field.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTackling Pancreatic Diseases
Discussion Leaders: Maike Sander (University of California, San Diego, USA) and Diane Simeone (NYU Langone Medical Center, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:10 pmDomenico Accili (Columbia University, USA)
"Diabetes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmAida Habtezion (Stanford University, USA)
"Pancreatitis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmSunil Hingorani (Fred Hutchinson Cancer Research Center, USA)
"Pancreatic Cancer"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular Plasticity in the Pancreas
Discussion Leaders: Jens Siveke (Essen University Hospital, Germany) and Francesca Spagnoli (Max Delbrueck Center for Molecular Medicine, Germany)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amQiao Zhou (Harvard University, USA)
"Cell Plasticity and Reprogramming"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amHoward Crawford (University of Michigan, USA)
"Acinar-to-Ductal Mataplasia: Forms and Functions"
10:00 am - 10:10 amDiscussion
10:10 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:10 amJennifer Bailey (University of Texas at Houston, USA)
"Targeting Ras Driven Cellular Heterogeneity for the Treatment of Pancreatic Cancer"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amShort Talk Selected from Poster Abstracts
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInflammation in Disease: Diabetes, Pancreatitis and Cancer
Discussion Leaders: Zobeida Cruz-Monserrate (Ohio State University, USA) and Michael Hollingsworth (University of Nebraska Medical Center, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmMarc Donath (University Hospital of Basel, Switzerland)
"Islet Inflammation: From Physiology to Type 2 Diabetes"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmCraig Logsdon (University of Texas MD Anderson Cancer Center, USA)
"Inflammation and Pancreatic Disease"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmFrancisco Real (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre, Spain)
"A Genomic View Linking Differentiation and Inflammation in the Exocrine Pancreas"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem/Progenitor Cells in the Pancreas
Discussion Leaders: Mark Huising (University of California, Davis, USA) and Lewis Murtaugh (University of Utah, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amFarzad Esni (University of Pittsburgh, USA)
"Characterization of Pancreatic Multipoint Cells Following Injury"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amTannishtha Reya (University of California, San Diego, USA)
"Pancreatic Cancer Stem Cells"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amSenthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Pancreatic Tumor Organoids for Translational Research"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenomics in Pancreatic Disease
Discussion Leaders: Eric Collisson (University of California, San Francisco, USA) and Kevin White (University of Chicago, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmBrian Wolpin (Dana-Farber/Brigham and Women's Cancer Center, USA)
"Using Genomics to Personalize Care for Pancreatic Adenocarcinoma"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmTalia Golan (Sheba Medical Center, Israel)
"The DDR Subtype in Pancreatic Cancer Discussion"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmSadik Esener (University of California, San Diego, USA)
"Exocrine and Endocrine Pancreas: From Molecules to Human"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegeneration of the Endocrine Pancreas
Discussion Leaders: Rohit Kulkarni (Harvard Medical School, USA) and Michele Solimena (Paul Langerhans Institute Dresden, Germany)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amLaura Alonso (University of Massachusetts, USA)
"Systemic Insulin Demand Regulates Pancreatic Beta Cell Proliferation"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amJames Johnson (University of British Columbia, Canada)
"Modulation of Beta-Cell Fate and Function by Insulin"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amMatthias Hebrok (University of California, San Francisco, USA)
"Maturation of Human Stem Cell Derived Beta Cells"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPancreatic Microenvironment
Discussion Leaders: Gregory Beatty (University of Pennsylvania, USA) and Marina Pasca di Magliano (University of Michigan, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmOwen Sampson (Beatson Institute for Cancer Research, University of Glasgow, United Kingdom)
"Targeting Myeloid Cells in Pancreatic Cancer"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmBrian Lewis (University of Massachusetts, USA)
"MTORC2 Signaling in PDAC Development and Progression"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmMonte Winslow (Stanford Medicine, USA)
"Blimp 1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Mechanisms of Cellular Communication
Discussion Leaders: Dafna Bar-Sagi (New York University School of Medicine, USA) and Rosalie Sears (Oregon Health and Science University, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amDaniel Marks (Oregon Health and Science University, USA)
"Signaling Pathways in PDAC Associated Cachexia"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amMike German (University of California, San Francisco, USA)
"Physiologic Regulation of Beta-Cell Turnover"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amAlec Kimmelman (NYU Langone Medical Center, USA)
"Identifying Metabolic Dependencies in Pancreatic Cancer"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMetabolism
Discussion Leaders: Rushika Perrara (University of California, San Francisco, USA) and Gina DeNicola (Moffitt Cancer Center, USA)
5:30 pm - 5:45 pmIntroduction by Discussion Leader
5:45 pm - 6:05 pmNabeel Bardeesy (Massachusetts General Hospital, USA)
"Metabolic Heterogeneity in KRAS Mutant Pancreatic Cancer"
6:05 pm - 6:15 pmDiscussion
6:15 pm - 6:35 pmNada Kalaany (Boston Children's Hospital / Harvard Medical School, USA)
"Metabolic Dependencies in Obesity-Associated Pancreatic Cancer"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmCostas Lyssiotis (University of Michigan, USA)
"Stromal Support of Pancreatic Tumor Metabolism"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:30 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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