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Pancreatic Diseases
Gordon Research Conference

Exocrine and Endocrine Pancreas: Molecules to Human

Dates

June 18-23, 2017

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Diane M. Simeone

Vice Chair:
Maike Sander

Meeting Description

Despite the rapid advances in our understanding of the molecular mechanisms involved in pancreatic development, regeneration, and malignant transformation, as well as our ability to model these processes in mice and recently also human cells, our ability to translate this knowledge into the clinical setting to benefit patients is still largely lacking. This relatively new GRC aims to link the understanding of the biology of the exocrine and endocrine pancreas to applications to human diseases. This GRC is unique in that it is the only conference that convenes experts from all aspects of pancreas biology as well as clinicians working on translational approaches for various pancreatic diseases, including pancreatic cancer, pancreatitis and diabetes. By providing a forum for the presentation and discussion of cutting edge, unpublished concepts and approaches, the goal of this GRC is to stimulate discussion across fields and disciplines. This exchange will foster interdisciplinary approaches in the field and promote exchange of ideas and experiences to lead to new collaborations, as well as empower young scientists to showcase their work to peers and leaders in the field.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTackling Pancreatic Diseases
Discussion Leaders: Maike Sander (University of California, San Diego, USA) and Diane Simeone (NYU Langone Medical Center, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:10 pmDomenico Accili (Columbia University, USA)
"Diabetes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmAida Habtezion (Stanford University, USA)
"Pancreatitis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmSunil Hingorani (Fred Hutchinson Cancer Research Center, USA)
"Pancreatic Cancer"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular Plasticity in the Pancreas
Discussion Leaders: Jens Siveke (German Consortium for Translational Cancer Research (DKTK) / Essen University Hospital, Germany) and Francesca Spagnoli (Max Delbrueck Center for Molecular Medicine, Germany)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amQiao Zhou (Harvard University, USA)
"Cell Plasticity and Reprogramming"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amHoward Crawford (University of Michigan, USA)
"Acinar-to-Ductal Mataplasia: Forms and Functions"
10:00 am - 10:10 amDiscussion
10:10 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:10 amJennifer Bailey (University of Texas Health Science Center at Houston, USA)
"Targeting Ras Driven Cellular Heterogeneity for the Treatment of Pancreatic Cancer"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amSelected from Poster Abstracts: Christina Adams (University of California, San Francisco, USA)
"Identifying Drivers of Tumor Heterogeneity in Pancreatic Cancer"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Hui-Ju Wen (University of Michigan, USA)
"Macrophage-Derived HB-EGF Contributes to Pancreatic Tissue Recovery"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmSelected from Poster Abstracts: Cristina Aguayo-Mazzucato (Joslin Diabetes Center / Harvard Medical School, USA)
"Insulin Resistance and Diabetes Increases Aging Markers in Rodent and Human Beta Cells"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInflammation in Disease: Diabetes, Pancreatitis and Cancer
Discussion Leaders: Zobeida Cruz-Monserrate (The Ohio State University, USA) and Michael Hollingsworth (University of Nebraska Medical Center, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmMarc Donath (University Hospital of Basel, Switzerland)
"Islet Inflammation: From Physiology to Type 2 Diabetes"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmCraig Logsdon (University of Texas MD Anderson Cancer Center, USA)
"Inflammation Outcomes Are Determined by Genetic Settings"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmFrancisco Real (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre, Spain)
"A Genomic View Linking Differentiation and Inflammation in the Exocrine Pancreas"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem/Progenitor Cells in the Pancreas
Discussion Leaders: Lewis Murtaugh (University of Utah, USA) and Beatriz Sosa-Pineda (Feinberg School of Medicine, Northwestern University, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amFarzad Esni (University of Pittsburgh, USA)
"Characterization of Pancreatic Multipoint Cells Following Injury"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amTannishtha Reya (University of California, San Diego, USA)
"Pancreatic Cancer Stem Cells"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amSenthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Pancreatic Tumor Organoids for Translational Research"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSelected from Poster Abstracts: Patrick Jacquemin (Université Catholique de Louvain, Belgium)
"Combining Oncogenic Kras Mutation and LKB1 Inactivation in Pancreatic Ductal Cells Reveals that Intraductal Papillary Mucinous Neoplasms Originate from Pancreatic Duct Glands"
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amSelected from Poster Abstracts: Lidong Wang (New York University School of Medicine, USA)
"ATDC Is Required for the Early Initiation of KRAS-Induced Pancreatic Tumorigenesis"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmSelected from Poster Abstracts: Kamini Singh (Memorial Sloan Kettering Cancer Center, USA)
"Targeting eIF4A Dependent Translation as Therapeutics in Pancreatic Cancer"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenomics in Pancreatic Disease
Discussion Leaders: Eric Collisson (University of California, San Francisco, USA) and Raymond Macdonald (University of Texas Southwestern Medical Center, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmBrian Wolpin (Dana-Farber/Brigham and Women's Cancer Center, USA)
"Using Genomics to Personalize Care for Pancreatic Adenocarcinoma"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmTalia Golan (Sheba Medical Center, Israel)
"The DDR Subtype in Pancreatic Cancer Discussion"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmKevin White (University of Chicago, USA)
"Genomic Insights from Clinical Patterns and Personalized Models"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegeneration of the Endocrine Pancreas
Discussion Leaders: Rohit Kulkarni (Harvard Medical School, USA) and Michele Solimena (Paul Langerhans Institute Dresden, Germany)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amLaura Alonso (University of Massachusetts Medical School, USA)
"Systemic Insulin Demand Regulates Pancreatic Beta Cell Proliferation"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amMark Huising (University of California, Davis, USA)
"Virgin Beta Cells Persist Throughout Life at a Neogenic Niche Within Healthy Pancreatic Islets"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amMatthias Hebrok (University of California, San Francisco, USA)
"Maturation of Human Stem Cell Derived Beta Cells"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSelected from Poster Abstracts: Evans Quilichini (Université Pierre-et-Marie-Curie (Paris VI), France)
"Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis and Leads to Pancreatitis and Neoplasia"
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amSelected from Poster Abstracts: Anguraj Sadanandam (Institute of Cancer Research (ICR), United Kingdom)
"Multi-Omics and Cross-Species Subtypes in Pancreatic Neuroendocrine Tumors with Distinct Cellular Origin, Pathophysiology, Metabolism and Clinical Characteristics"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmSelected from Poster Abstracts: Olov Andersson (Karolinska Institutet, Sweden)
"Inhibition of Cdk5 Promotes β-Cell Differentiation from Ductal Progenitors in Zebrafish and Mouse/Human Stem Cells"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPancreatic Microenvironment
Discussion Leaders: Marina Pasca di Magliano (University of Michigan, USA) and Yuliya Pylayeva-Gupta (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmJen Morton (CRUK Beatson Institute, United Kingdom)
"Targeting Myeloid Cells in Pancreatic Cancer"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmGregory Beatty (University of Pennsylvania, USA)
"Mechanisms Regulating a Pro-Metastatic 'Soil' that Supports Pancreatic Cancer 'Seeding'"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmMonte Winslow (Stanford University, USA)
"Blimp 1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Mechanisms of Cellular Communication
Discussion Leaders: Rosalie Sears (Oregon Health and Science University, USA) and David Dawson (University of California, Los Angeles, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:35 amDaniel Marks (Oregon Health and Science University, USA)
"Signaling Pathways in PDAC Associated Cachexia"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amMike German (University of California, San Francisco, USA)
"Physiologic Regulation of Beta-Cell Turnover"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amAlec Kimmelman (NYU Langone Medical Center, USA)
"Identifying Metabolic Dependencies in Pancreatic Cancer"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:30 amSelected from Poster Abstracts: Juntaro Matsuzaki (National Cancer Center Research Institute, Japan)
"In Vitro Chemically-Induced Reprogramming of Pancreatic Acinar Cells to Pancreatic Progenitor-Like Cells"
11:30 am - 11:35 amDiscussion
11:35 am - 11:50 amSelected from Poster Abstracts: Jungsun Kim (University of Pennsylvania, USA)
"Developing a Plasma Marker Panel to Detect Pancreatic Ductal Adenocarcinoma"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmSelected from Poster Abstracts: Alexander Kleger (Ulm University, Germany)
"ATM-Deficiency Generates Genomic Instability in Pancreatic Ductal Adenocarcinoma and Sensitizes Toward Therapeutic DNA-Damage"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMetabolism
Discussion Leaders: Rushika Perera (University of California, San Francisco, USA) and Gina DeNicola (Moffitt Cancer Center, USA)
5:30 pm - 5:45 pmIntroduction by Discussion Leader
5:45 pm - 6:05 pmNabeel Bardeesy (Massachusetts General Hospital, USA)
"Metabolic Heterogeneity in KRAS Mutant Pancreatic Cancer"
6:05 pm - 6:15 pmDiscussion
6:15 pm - 6:35 pmNada Kalaany (Boston Children's Hospital / Harvard Medical School, USA)
"Metabolic Dependencies in Obesity-Associated Pancreatic Cancer"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmCostas Lyssiotis (University of Michigan, USA)
"Stromal Support of Pancreatic Tumor Metabolism"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:30 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible by 1 R13 DK 114948 -01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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