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Synthetic Biology
Gordon Research Conference

Biology by Design

Dates

July 30 - August 4, 2017

Location

Stoweflake Conference Center
Stowe, VT Site Information

Organizers

Chair:
Farren Isaacs

Vice Chair:
Vitor B. Pinheiro

Application Deadline

Applications for this meeting must be submitted by July 2, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The field of synthetic biology remains an emerging discipline that is beginning to impact diverse fields of basic and applied science. In brief, synthetic biology seeks to (i) design and construct biological components and systems that do not exist in nature and (ii) re-design and build existing biological systems. Such approaches to engineering biological systems use unnatural molecules to expand the chemistry and function of life as well as re-assemble natural components into artificial systems with programmable behaviors. Inspired by these goals, the field has driven dramatic innovations in genomic and biomolecular technologies and the enablement of sophisticated programming of microbial and eukaryotic species and communities. This meeting will provide reports of unpublished data on the latest enabling technologies, advances in environmental and mammalian applications, the engineering of undomesticated species and communities, sophisticated re-design of multi-scale systems at the gene, network and whole-genome level, and the growth of synthetic biology in industry.

Reflective of the interdisciplinary field of synthetic biology, this meeting will resemble an "artists' colony" bringing together scientists from biology, chemistry, physics, mathematics and engineering to interact in a stimulating and relaxed environment. In this informal atmosphere, scientists at all stages – graduate students, postdoctoral fellows and established investigators – will have the opportunity to engage in spirited conversation over meals, during session discussions, throughout afternoon activities and into the evening after each session.

For the first time the conference will incorporate a Gordon Research Seminar (GRS) with the goal of facilitating participation by scientists at the graduate student and postdoctoral levels. The GRS is planned by and for trainees to provide an interactive and supportive environment for junior researchers to present seminars and posters. Participation at the GRS will also provide opportunities for select junior scientists to present at the associated GRC.

Funding Notice: The GRS and GRC have special funding available to encourage participation from underrepresented racial and ethnic minority groups. Applicants who would like to give an oral presentation should note whether they would like to be considered for this funding.

Related Meeting

This GRC will be held in conjunction with the "Synthetic Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEnvironmental Synthetic Biology
Discussion Leader: Andrew Ellington (University of Texas at Austin, USA)
7:40 pm - 8:20 pmJames Collins (Massachusetts Institute of Technology, USA)
"Synthetic Biology for Global Health"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmLate-Breaking Topic
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmExotic Molecules and Materials
Discussion Leader: Alanna Schepartz (Yale University, USA)
9:00 am - 9:40 amNico Callewaert (Ghent University, Belgium)
"Reconstructing and Deconstructing Biopharmaceutical Glycosylation"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amMichelle Chang (University of California, Berkeley, USA)
"Metabolic Engineering Approaches to Bioorthogonal Chemistry"
11:10 am - 11:30 amDiscussion
11:30 am - 11:50 amTalk Selected from the GRS
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBiological Design, Automation and Computation
Discussion Leader: Sven Panke (ETH Zurich, Switzerland)
7:30 pm - 8:10 pmRinaldo Montalvao (Pontifical Catholic University of Rio Grande do Sul (PUCRS), Brazil)
"Modeling Protein-Protein Complexes"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmChristopher Voigt (Massachusetts Institute of Technology, USA)
"Design and Surveillance"
9:10 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMammalian Synthetic Biology
Discussion Leader: Michelle Chang (University of California, Berkeley, USA)
9:00 am - 9:40 amYvonne Chen (University of California, Los Angeles, USA)
"Engineering Smarter and Stronger T Cells for Cancer Immunotherapy"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amJamie Davies (University of Edinburgh, United Kingdom)
"Synthetic Morphology"
11:10 am - 11:30 amDiscussion
11:30 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEngineering Microbial Communities
Discussion Leader: Ahmad Khalil (Boston University / Wyss Institute, Harvard University, USA)
7:30 pm - 8:10 pmPamela Silver (Harvard University, USA)
"Re-Programming the Gut Microbiome"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmFilipe Cabreiro (University College London, United Kingdom)
"Engineering in the C. elegans Gut"
9:10 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnabling Technologies
Discussion Leader: Paul Freemont (Imperial College London, United Kingdom)
9:00 am - 9:40 amAhmad Khalil (Boston University / Wyss Institute, Harvard University, USA)
"Epigenetics and Evolution in the Age of Synthetic Biology"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amAlanna Schepartz (Yale University, USA)
"Visualizing Organelle Dynamics for (Almost) Forever at Super-Resolution"
11:10 am - 11:30 amDiscussion
11:30 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmIndustrial Applications of Synthetic Biology
Discussion Leader: Philippe Marliere (Heurisko GmbH, Germany)
7:30 pm - 8:10 pmEmily Leproust (Twist Bioscience, USA)
"The Synthetic DNA Engine for the Bioeconomy"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmReshma Shetty (Ginkgo Bioworks, USA)
"Rapid Prototyping for Custom Organisms Design"
9:10 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiological Circuits
Discussion Leader: Pamela Silver (Harvard University, USA)
9:00 am - 9:40 amSven Panke (ETH Zurich, Switzerland)
"From Evolving to Designing Function"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amChang Liu (University of California, Irvine, USA)
"Orthogonal Replication for Rapid Mutation and Synthetic Biology"
11:10 am - 11:30 amDiscussion
11:30 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDesigning and Writing Genomes
Discussion Leader: Marc Lajoie (University of Washington, USA)
7:30 pm - 8:10 pmAbhishek Chatterjee (Boston College, USA)
"Development and Applications of Universal Platforms for Genetic Code Expansion"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmPatrick Yizhi Cai (University of Edinburgh, United Kingdom)
"Synthetic Genomics: Engineering Synthetic Chromosomes and ncRNAs in Yeast"
9:10 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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