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Posttranslational Modification Networks
Gordon Research Conference

Regulation Mechanisms of Proteins and Signaling Pathways in Humans, Animals and Plants

Dates

August 13-18, 2017

Location

The Hong Kong University of Science and Technology
Hong Kong, China Site Information

Organizers

Chairs:
Heribert Hirt & Lan Huang

Vice Chairs:
Steven P. Briggs & Yingming Zhao

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Meeting Description

The 2017 Gordon Conference on Posttranslational Modification Networks will present the latest development on approaches how the protein machinery and signaling pathways function in the context of various cellular systems. The genomic era has generated an enormous amount of information about the number of genes different organisms have and when they are expressed. However, we still know very little about how the encoded proteins function in the context of the molecular machines that underlay the essential cellular mechanisms such as transcription, translation or the primary metabolism. An understanding of these cellular systems is strongly dependent on the technologies to analyze the composition, behavior and regulation of proteins and protein complexes. The Gordon Conference 2017 on Posttranslational Networks will present advances in studying proteins and signaling pathways by using most modern developments in proteomics, bioinformatics, biochemistry and structural biology with a major focus on post-translational modifications (PTMs). The Conference will feature a wide range of topics, such as the detection and quantitative analysis of various PTMs, including protein phosphorylation, ubiquitination, glycosylation, alkylation or nitrosylation in protein networks of humans, animals and plants. The Conference will showcase how biological problems can be addressed by using genomics, proteomics, mass spectrometry, structural biology as well as computational and systems biology approaches. Invited speakers are at the forefront of their field and represent a variety of scientific disciplines, including animal, medical and plant sciences. Besides the programmed discussion and poster sessions, informal gatherings in the afternoons and evenings will enable scientists from different disciplines to brainstorm and develop cross-disciplinary collaborations. Early career scientists and students will be able to discuss their data with leaders in the field throughout the conference. In addition to presenting their work in dedicated slots throughout the program, the Gordon Research Seminar will provide opportunities for students and post-docs to present their work in poster format and exchange ideas with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Posttranslational Modification Networks" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCellular Signaling Networks and Controls
Discussion Leader: Heribert Hirt (King Abdullah University of Science and Technology (KAUST), Saudi Arabia)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:25 pmRuedi Aebersold (Institute of Molecular Systems Biology, ETH Zurich, Switzerland)
"Quantitative Peptidoform Profiling by SWATH/DIA Mass Spectrometry"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmPeipei Ping (University of California, Los Angeles, USA)
"Building Protein Signatures of Cardiovascular Diseases from Unstructured Data: A Machine Learning-Based Text Mining Approach"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmZiv Bar-Joseph (Carnegie Mellon University, USA)
"Reconstructing Dynamic Regulatory and Signalling Response Networks"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmKinases, Gene Regulation and Chromatin Dynamics
Discussion Leader: Yingming Zhao (The University of Chicago, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amWolfgang Fischle (King Abdullah University of Science and Technology (KAUST), Saudi Arabia)
"Molecular Analysis of Histone Modification Readout"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amNaganand Rayapuram (King Abdullah University of Science and Technology (KAUST), Saudi Arabia)
"Chromatin Phosphoproteomics to Understand Biotic Stress Signaling in Arabidopsis"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amAnne-Claude Gingras (Lunenfeld-Tanenbaum Research Institute, Canada)
"Systematic Interaction Profiling of Human Bromodomain-Containing Proteins Reveals Complex Modes of Binder Recruitment for BET Proteins"
10:40 am - 10:45 amDiscussion
10:45 am - 11:25 amGroup Photo / Coffee Break
11:25 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRoles and Functions of Protein Glycosylation
Discussion Leader: Carlito Lebrilla (University of California, Davis, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmAlma Burlingame (University of California, San Francisco, USA)
"Protein O-GlcNAcylation: The Occurrence, Sites and Biological Functions Revealed by ETD MS"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmHui Zhang (Johns Hopkins University, USA)
"Functional Analysis of Glycosylation by Identification of Proteins and Pathways Associated with Glycogene Expression"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmRonghu Wu (Georgia Institute of Technology, USA)
"Effective Chemical and Enzymatic Methods to Globally Characterize Protein Glycosylation"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMiscellaneous PTMs and Biological Functions
Discussion Leader: Lan Huang (University of California, Irvine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amRoman Zubarev (Uppsala University, Sweden)
"Isoaspartic Acid, Its Role and Network - A Proteomics Study"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amCarlito Lebrilla (University of California, Davis, USA)
"Aberrant Glycosylation Affects Protein Function Having Implications in Disease Diagnostic and Therapeutics"
10:05 am - 10:10 amDiscussion
10:10 am - 10:35 amJun Qin (Beijing Proteome Research Center, China)
"Altered Signaling Pathways in Gastric Cancer"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amShort Talk Selected from Poster Abstracts
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmRoles and Functions of Protein Phosphorylation
Discussion Leader: Steven Briggs (University of California, San Diego, USA)
4:00 pm - 4:10 pmIntroduction by Discussion Leader
4:10 pm - 4:35 pmCyril Zipfel (Sainsbury Laboratory, United Kingdom)
"Regulation of Receptor Kinase-Mediated Innate Immunity"
4:35 pm - 4:40 pmDiscussion
4:40 pm - 5:05 pmJian-Min Zhou (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China)
"How Does a Plant Receptor Regulate Heterotrimeric G Proteins?"
5:05 pm - 5:10 pmDiscussion
5:10 pm - 5:25 pmShort Talk Selected from Poster Abstracts
5:25 pm - 5:30 pmDiscussion
5:30 pm - 5:45 pmShort Talk Selected from Poster Abstracts
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:00 pmGeneral Discussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Ubiquitilation and Protein Complexes
Discussion Leader: Zhiyong Wang (Carnegie Institution for Science, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amMatthias Peter (ETH Zurich Hönggerberg, Switzerland)
"Ubiquitin-Dependent Regulation of Cell Growth and Division"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amJoe Loo (University of California, Los Angeles, USA)
"Mass Spectrometry of Protein Complexes, Modifications, and Their Impact on Metabolism"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amLate-Breaking Topic
11:05 am - 11:10 amDiscussion
11:10 am - 11:25 amShort Talk Selected from Poster Abstracts
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPTMs and Systems Biology
Discussion Leader: Ruedi Aebersold (Institute of Molecular Systems Biology, ETH Zurich, Switzerland)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmYinsheng Wang (University of California, Riverside, USA)
"Targeted Proteomic Approaches for Interrogating the Human Kinome"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmYasushi Ishihama (Kyoto University, Japan)
"Kinase-Centric Phosphoproteomics Approaches for Cell Signaling Analysis"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJesper Velgaard Olsen (University of Copenhagen, Denmark)
"Dissecting Cellular Signaling Networks by Quantitative Phosphoproteomics"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRole of PTMs in Novel Pathways
Discussion Leader: Roman Zubarev (Uppsala University, Sweden)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amZhiyong Wang (Carnegie Institution for Science, USA)
"Regulation of RNA Alternative Splicing by Phosphorylation in Arabidopsis"
9:35 am - 9:40 amDiscussion
9:40 am - 10:05 amGary Loake (University of Edinburgh, United Kingdom)
"A Sleigh Ride Through the SNO: Role of S-Nitrosylation in Plant Immunity"
10:05 am - 10:10 amDiscussion
10:10 am - 10:35 amJosh Labaer (Biodesign Institute, Arizona State University, USA)
"Adapting Functional Protein Microarrays to Include Post Translational Modification. New Territory for Identifying Biomarkers and Therapeutic Targets"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amShort Talk Selected from Poster Abstracts
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPTM Cross-Talk and Cellular Pathways
Discussion Leader: Jesper Velgaard Olsen (University of Copenhagen, Denmark)
4:00 pm - 4:10 pmIntroduction by Discussion Leader
4:10 pm - 4:35 pmWaltraud Schulze (University of Hohenheim, Germany)
"Identification of Kinase Substrate Relationships from Conditional Large Scale Phosphoproteomics"
4:35 pm - 4:40 pmDiscussion
4:40 pm - 5:05 pmFrank van Breusegem (VIB, Ghent University, Belgium)
"Oxidative Post-Translational Modifications of Cysteine Residues in Plant Signal Transduction"
5:05 pm - 5:10 pmDiscussion
5:10 pm - 5:25 pmShort Talk Selected from Poster Abstracts
5:25 pm - 5:30 pmDiscussion
5:30 pm - 5:45 pmShort Talk Selected from Poster Abstracts
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:00 pmClosing Remarks
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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