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Antibody Biology & Engineering (GRS)
Gordon Research Seminar

Modulation and Mechanisms of Antibody Activity

Dates

March 19-20, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Kristi Baker & Anja Lux

Meeting Description

The Gordon Research Seminar on Antibody Biology and Engineering is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting will be the mechanisms by which antibodies mediate their activity and how such activity can be modulated to enhance their use in therapeutic applications. The meeting will discuss topics including antibody-receptor interactions, antibody-target interactions, non-classical mechanisms of antibody action, and antibody engineering to improve effector function.

Related Meeting

This GRS was held in conjunction with the "Antibody Biology & Engineering" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Antibody Modifications to Improve Receptor Binding
This session of the program will focus on discussing some of the major structural features that are naturally present in the antibody repertoire and how these can inform the rational design of therapeutic antibodies.
Discussion Leader: Kristi Baker (University of Alberta, Canada)
3:45 pm - 4:15 pmGeorge Georgiou (The University of Texas at Austin, USA)
"Applied Immunology and the Development of Antibody Therapeutics"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPathogenicity and Therapy - Dual Role for Ig in Disease
In this session, speakers will present their work investigating the role of IgG and IgG immune complexes on the onset, progression and treatment of disease.
Discussion Leader: Ambily Abraham (Indian Institute of Science, India)
7:30 pm - 7:50 pmKaitlin Sawatzki (Boston University, USA)
"Non-Specific Activation of Autoreactive B Cells After Anthrax Vaccination Delays Protection"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMalin Bern (University of Oslo, Norway)
"Engineering of Albumin for Improved FcRn-Mediated Transcytosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKarin van Schie (Sanquin, The Netherlands)
"The Biological Effect of Immune Complexes in Infusion Reactions Towards Infliximab"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmWillem Falkenburg (Sanquin Research, The Netherlands)
"Anti-Hinge Antibodies Recognize IgG Subclass- and Protease-Restricted Hinge Neo-Epitopes and Can Serve as Targets for Rheumatoid Factors"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amAntibody Engineering for Therapeutic Optimization
This session will cover receptor discovery, antibody discovery and engineering methods that are currently being tested for use to enhance half-life or therapeutic antibody function.
Discussion Leader: Martin McAdam (Oslo University Hospital, Rikshospitalet, Norway)
9:00 am - 9:20 amGillian Dekkers (Sanquin Blood Supply, The Netherlands)
"Elucidation of the Functional Consequences of Naturally Occurring Glycan Changes in Humoral IgG Responses Through Glyco-Engineering"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amFleur van de Bovenkamp (Sanquin Research, The Netherlands)
"Fab Glycosylation Represents an Additional Mechanism of Antibody Diversification that Modulates Antigen Binding"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amNing Zhao (Colorado State University, USA)
"Selection of Nanomolar Affinity Binding Proteins for Active Tuberculosis Diagnosis from an Sso7d Alternative Scaffold Phage Display Library"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amMichal Pyzik (Brigham and Women's Hospital, USA)
"Identification of a Novel FcRn Ligand"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Anja Lux (University of Erlangen-Nurnberg, Germany)
1:30 pm - 2:30 pmPanel Discussion
"How to Begin a Career in Industry vs Academia"
  • Richard Blumberg (Brigham and Women's Hospital / Harvard Medical School, USA)
  • Paul Carter (Genentech, Inc., USA)
  • Leo James (Medical Research Council, United Kingdom)
  • Janine Schuurman (Genmab, The Netherlands)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible [in part] by 1R13AI122628-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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