Gordon Research Conferences
Meeting Details

Cyclic Nucleotide Phosphodiesterases (GRS)
Gordon Research Seminar

New Layers of Complexity in Cyclic Nucleotide Phosphodiesterase Signaling


June 11-12, 2016


PGA Catalunya Business and Convention Centre
Girona, Spain


Alessandra Ghigo & Sarah N. Rampersad

Meeting Description

The Gordon Research Seminar on Cyclic Nucleotide Phosphodiesterases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to highlight emerging paradigms in cyclic nucleotide phosphodiesterase signaling that include, but are not limited to, mechanisms of nanodomain signal transduction. It will also explore the recently developed techniques, tools and models used to investigate the structure and function of cyclic nucleotide nanodomains. A mentorship session will also be offered to provide students with the opportunity to meet informally with experts in both academia and industry, for roundtable discussions on career opportunities and strategies for career development in today's challenging and ever-changing research environment.

Related Meeting

This GRS was held in conjunction with the "Cyclic Nucleotide Phosphodiesterases" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmNew Layers of Complexity of PDE Signaling in the Cardiovascular System
Discussion Leader: Nachiket Pendse (West Virginia University School of Medicine, USA)
3:15 pm - 3:25 pmDelphine Mika (INSERM U1180, University of Paris-Sud, France)
"Regulation of Pacemaker Activity by PDE4 Isoforms"
3:25 pm - 3:30 pmDiscussion
3:30 pm - 3:40 pmJodi MacKeil (Queen's University, Canada)
"Leading the Charge in Sprouting Angiogenesis: The Roles of PDE4D and PDE3B in Regulating Tip Cell Invasion"
3:40 pm - 3:45 pmDiscussion
3:45 pm - 3:55 pmSarah Idres (INSERM U1180, University of Paris-Sud, France)
"Key Role of BK(Ca) Channels for PDE3 and PDE4 to Regulate Coronary Tone Is Lost in Heart Failure"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMicrodomains and Nanodomains of Cyclic Nucleotide Signaling
Discussion Leader: Cristina Molina (Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany)
5:30 pm - 5:45 pmAxel Kraft (University Medical Center Hamburg-Eppendorf, Germany)
"Influence of Phosphodiesterases 4B and 4D on cAMP Signaling in Calcium Handling Microdomains of Adult Mouse Cardiomyocytes"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmBracy Fertig (University of Glasgow, United Kingdom)
"Phosphodiesterase PDE4D9 Localises to the Myofilament to Regulate Troponin I Phosphorylation by Protien Kinase A"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmIbrahim Bedioune (INSERM U1180, University of Paris-Sud, France)
"Differential Regulation of Cytoplasmic and Nuclear PKA Activities by β1- and β2-Adrenoceptors in Adult Cardiac Myocytes"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmPaulina Brzezinska (Queen's University, Canada)
"The Interplay of cAMP and Calcium Signaling in the Regulation of PDE1C in Human Vascular Smooth Muscle Cells"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmWill Capell (University of South Carolina School of Medicine, USA)
"Identification of Intramolecular Signals Controlling PDE11A4 Subcellular Compartmentalization"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmZhenyu Wang (INSERM U1180, University of Paris-Sud, France)
"Mitochondrial Soluble Adenylyl Cyclase, Phosphodiesterases and Epac Regulate Cardiac Mitochondrial Function and Cell Death"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amEmerging Paradigms in Cyclic Nucleotide Phosphodiesterase Signaling / Keynote Session: The Multiple Facets of cAMP Signaling
Discussion Leader: Delphine Mika (INSERM U1180, University of Paris-Sud, France)
9:00 am - 9:15 amSi Chen (University of Rochester, USA)
"The Role of PDE10A in Pathological Cardiac Remodeling and Dysfunction"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amCristina Molina (Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany)
"PDE8 Is a Novel Regulator of cAMP Signaling in Human Atrial Fibrillation"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amNachiket Pendse (West Virginia University School of Medicine, USA)
"Lipid Modification of Phosphodiesterase 6 (PDE6) Is Crucial for Its Assembly and Color Vision"
9:55 am - 10:00 amDiscussion
10:00 am - 10:50 amManuela Zaccolo (University of Oxford, United Kingdom)
"cAMP: From Long-Range Messenger to Nano-Domain Signalling"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Building a Successful Career in Scientific Research
Discussion Leaders: Alessandra Ghigo (University of Torino, Italy) and Sarah Rampersad (Queen's University, Canada)
1:30 pm - 2:30 pmPanel Discussion
"How to Succeed in Science: Tips and Advice for Young Scientists"
  • Viacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
  • Jin Zhang (University of California, San Diego, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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