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Diffraction Methods in Structural Biology (GRS)
Gordon Research Seminar

Protein Function in Time and Space: Insights from Diffraction Experiments

Dates

July 16-17, 2016

Location

Bates College
Lewiston, ME

Organizers

Chairs:
Henrike M. Mueller-Werkmeister & Bradley J. Hintze

Meeting Description

The Gordon Research Seminar on Diffraction Methods in Structural Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Come meet your fellow graduate and postgraduate researchers and discuss the latest in diffraction methods. We will cover many exciting topics including time-resolved diffraction via XFEL, data analysis, electron diffraction, and coherent diffractive imaging. Learn aspects of the whole process; sample delivery, experimental methods, data analysis, and biological function.

Related Meeting

This GRS was held in conjunction with the "Diffraction Methods in Structural Biology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Time-Resolved Crystallography
Discussion Leader: Helen Ginn (University of Oxford, United Kingdom)
3:45 pm - 4:15 pmEmil Pai (University of Toronto, Canada)
"Time-Resolved Crystallography: 30 Years – From p21 to Defluorinase"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Breakthrough Methods in Crystallographic Data Processing
Discussion Leader: Rahel Woldeyes (University of California, San Francisco, USA)
7:30 pm - 7:50 pmHelen Duyvesteyn (University of Oxford, United Kingdom)
"From SAD to trSFX: Experiences of a Novice Xfellographer"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNicholas Pearce (University of Oxford, United Kingdom)
"Ex Pluribus, Multi: Multi-Dataset Methods for the Extraction of Protein Flexibility and Heterogeneity"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmOleksandr Yefanov (Center for Free-Electron Laser Science (CFEL), Germany)
"3D Merging: Getting More from Protein Crystallography"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRyan Jackson (Montana State University, USA)
"Combining Cryo-EM and X-Ray Data to Determine the Crystal Structure of the CRISPR RNA-Guided Complex from Escherichia coli"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amUsing Novel Methods to Answer Important Biological Questions
Discussion Leader: Jessica Besaw (University of Toronto, Canada)
9:00 am - 9:15 amRahel Woldeyes (University of California, San Francisco, USA)
"Visualizing Solvent in the Pore of the Influenza AM2 Proton Channel"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amOskar Aurelius (Diamond Light Source, United Kingdom)
"Beyond the Sulfur Edge – Long Wavelength MX Capabilities of the I23 Beamline at Diamond"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amAsim Bera (Biotechnology Institute, University of Minnesota, USA)
"Structure of the Cyanuric Acid Hydrolase TrzD Reveals Product Exit Channel"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amJavaria Najeeb (Duke University, USA)
"Drug Design from the Cryptic Inhibitor Envelope"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSwagatha Ghosh (Institute of Stem Cell Biology and Regenerative Medicine, India)
"A Blue Protein with Red Fluorescence"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amPrasun Kundu (Indian Institute of Technology, Kharagpur, India)
"Structure Based Epitope Mapping of a 28kDa Secretary Antigen: A Probable Diagnostic Marker from Mycobacterium tuberculosis"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Future of Crystallography
Discussion Leader: Bradley Hintze (Duke University, USA)
1:30 pm - 2:30 pmPanel Discussion
"Future of Crystallography - Q&A"
  • Emil Pai (University of Toronto, Canada)
  • Edward Snell (Hauptman-Woodward Medical Research Institute, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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