Gordon Research Conferences
Meeting Details

Drug Carriers in Medicine & Biology (GRS)
Gordon Research Seminar

Leveraging Drug Carrier Design and Mechanistic Insight of Nanoparticle Therapeutics to Optimize Clinical Efficacy


August 6-7, 2016


Waterville Valley
Waterville Valley, NH


Ramsey N. Majzoub & Santiago Correa-Echavarria

Meeting Description

The 2016 Gordon Research Seminar for Drug Carriers in Medicine and Biology is a forum for young researchers to present and exchange ideas pertaining to the field of drug delivery. Researchers from both academia and the biotech/pharmaceutical industries will have an opportunity to engage in stimulating scientific discussions that bridge a variety of disciplines including material science, cancer therapy and immunology. The Drug Carriers GRS aims to bring scientists at a similar point in their careers together to build professional networks and meaningful scientific collaborations.

This meeting focuses on the synthesis, scale-up and characterization of therapeutic nanoparticles; the biochemical and biophysical interactions between drug carriers and cells; the critical evaluation of in vivo drug delivery efficacy; and the advances in understanding the immune system's role in nanomedicine. The overarching theme will explore how findings from different sub-fields of drug delivery (e.g., basic science, engineering and clinical) can guide the broader field towards the clinical translation of nanomedicines.

Related Meeting

This GRS was held in conjunction with the "Drug Carriers in Medicine & Biology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Application of Systems Pharmacology Principles to the Development of nal-IRI, Liposomal Irinotecan
Discussion Leader: James Kaczmarek (Massachusetts Institute of Technology, USA)
3:45 pm - 4:20 pmJonathan Fitzgerald (Merrimack, USA)
"Application of Systems Pharmacology Principles to the Development of nal-IRI, Liposomal Irinotecan"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNanoparticle Preparation, Characterization, and Scale Up
Discussion Leader: Santiago Correa-Echavarria (Massachusetts Institute of Technology, USA)
7:30 pm - 7:50 pmIoana Aanei (University of California, Berkeley, USA)
"Viral Capsids as Versatile Scaffolds for Drug Delivery Applications"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmErin Wilson (University of North Carolina at Chapel Hill, USA)
"Engineering PRINT® Dry Powders for Pulmonary Drug Delivery"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmLeo Chou (Dana-Farber Cancer Institute / Harvard Medical School, USA)
"Building an RNA-Extruding Nanofactory Within DNA Origami Nanocapsule"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmBrett Geiger (Massachusetts Institute of Technology, USA)
"Design Considerations and Strategies for Cartilage-Penetrating Nanoparticles"
9:20 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amBiophysical and Biochemical Interactions of Nanoparticles with Cells
Discussion Leader: Armando Hernandez-Garcia (Northwestern University, USA)
9:00 am - 9:20 amAaron Anselmo (Massachusetts Institute of Technology, USA)
"Hitchhiking Nanoparticles on Red Blood Cells: A Stealth Approach for Targeted Nanoparticle Delivery"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSiddharth Patel (Oregon State University, USA)
"Mechanisms of Intracellular Trafficking and Endosomal Escape of Nanoparticle-mRNA Therapeutics"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amLorena Simon Gracia (University of Tartu, Estonia)
"pH-Sensitive Polymersomes Targeted with CendR Peptides for Treatment of Peritoneal Carcinomatosis"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amErik Munsell (University of Delaware, USA)
"Histone-Targeted Gene Delivery Carriers for Bone Regeneration"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmDrug Delivery In Vivo
Discussion Leader: Shrey Sindhwani (University of Toronto, Canada)
1:30 pm - 1:50 pmChintan Kapadia (University of North Carolina at Chapel Hill, USA)
"Engineering PRINT® Nanoparticle Subunit Vaccine to Induce Antitumor Immune Response"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmEmily Wyatt (California Institute of Technology, USA)
"Design of Targeted Nanoparticle Therapeutics for Treating Intracranial Disease and Improved Preclinical Models"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13EB021764-01 from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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