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Fragile X and Autism-Related Disorders (GRS)
Gordon Research Seminar

Fragile X and ASDs: Unlocking Complex Disorders with Basic Research

Dates

June 4-5, 2016

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Kirsty J. Sawicka & Sally Till

Meeting Description

The Gordon Research Seminar on Fragile X and Autism-Related Disorders is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will focus on recent advances in the field that have provided insight into the underlying mechanisms of autism spectrum disorders and how these research findings can be translated into the clinic. The program will highlight the complex nature but also the similarities between diverse syndromes and explore the relation between dysregulation at the molecular level and behavioral consequences. As well as a varied scientific program of talks and posters from fellow students and postdocs, there will be the opportunity to pose questions to a panel of experts composed of academic investigators, clinicians and funding agencies who will be discussing the recent progress and difficulties in taking basic research into the clinic.

Related Meeting

This GRS was held in conjunction with the "Fragile X and Autism-Related Disorders" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Fragile X Syndrome: Discoveries and New Approaches
Discussion Leader: Michael Tranfaglia (FRAXA Research Foundation, USA)
3:45 pm - 3:50 pmIntroduction by Discussion Leader
3:50 pm - 4:20 pmPeter Kind (University of Edinburgh, United Kingdom)
"Fragile X Syndrome: Discoveries and New Approaches"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Genetic and Physiological Basis of ASDs
Discussion Leader: Ilse Gantois (McGill University, Canada)
7:30 pm - 7:50 pmWeirui Guo (University of Texas Southwestern Medical Center, USA)
"Mechanisms of mGluR5 Dysfunction in a Fragile X Syndrome Mouse Model"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmGiselle Fernandes (National Center for Biological Sciences, India)
"mGluR-Dependent Plasticity in the Amygdala and Fragile X Syndrome"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRachel Sare (National Institute of Mental Health, NIH, USA)
"Long-Term Effects of Chronic Sleep Restriction on Behavior in Fmr1 KO Mice"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMargaret King (Geisinger Health System, USA)
"Heritable Quantitative Traits and Implications for the Study of Phenotypic Heterogeneity in Fragile X Syndrome"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amIdentification and Investigation of New Therapeutic Targets
Discussion Leader: Margaret King (Geisinger Health System, USA)
9:00 am - 9:20 amEllen Hoffman (Yale University, USA)
"High-Throughput Drug Discovery in Zebrafish Models of Autism Risk Genes"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDawn Lammert (State University of New York Upstate Medical University, USA)
"RELN Mutations Identified in Autism Spectrum Patients Cause a Protein Biosynthetic Defect"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAmit Modgil (Tufts University, USA)
"Neurosteroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amElizabeth Berry-Kravis (Rush University Medical Center, USA)
"An Update on Fragile X Clinical Trials"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Translating Basic Research into the Clinic
A panel of experts composed of academic investigators, clinicians and funding agencies will be discussing recent progress and difficulties of taking basic research into the clinic.
Discussion Leader: Sally Till (University of Edinburgh, United Kingdom)
1:30 pm - 2:30 pmPanel Discussion
"Translating Basic Research into the Clinic"
  • Elizabeth Berry-Kravis (Rush University Medical Center, USA)
  • Christina Gross (Cincinnati Children's Hospital Medical Center, USA)
  • Laura Mamounas (National Institute of Neurological Disorders and Stroke, NIH, USA)
  • Paul Wang (Autism Speaks, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13 HD088062-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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