The Gordon Research Seminar on Fragile X and
Autism-Related Disorders is a unique forum for graduate students, post-docs,
and other scientists with comparable levels of experience and education to
present and exchange new data and cutting edge ideas.
This meeting will focus on recent advances in the
field that have provided insight into the underlying mechanisms of autism
spectrum disorders and how these research findings can be translated into the
clinic. The program will highlight the complex nature but
also the similarities between diverse syndromes and explore the relation
between dysregulation at the molecular level and behavioral consequences. As well as a varied scientific program of talks and posters from fellow students and postdocs, there will be the opportunity to pose questions to a panel of experts composed of academic investigators, clinicians and funding agencies who will be discussing the recent progress and difficulties in taking basic research into the clinic.
This GRS was held in conjunction with the "Fragile X and Autism-Related Disorders" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
Final Meeting Program
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: Fragile X Syndrome: Discoveries and New Approaches|
|Discussion Leader: Michael Tranfaglia (FRAXA Research Foundation, USA)|
|3:45 pm - 3:50 pm||Introduction by Discussion Leader|
|3:50 pm - 4:20 pm||Peter Kind (University of Edinburgh, United Kingdom)|
"Fragile X Syndrome: Discoveries and New Approaches"
|4:20 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||The Genetic and Physiological Basis of ASDs|
|Discussion Leader: Ilse Gantois (McGill University, Canada)|
|7:30 pm - 7:50 pm||Weirui Guo (University of Texas Southwestern Medical Center, USA)|
"Mechanisms of mGluR5 Dysfunction in a Fragile X Syndrome Mouse Model"
|7:50 pm - 8:00 pm||Discussion|
|8:00 pm - 8:20 pm||Giselle Fernandes (National Center for Biological Sciences, India)|
"mGluR-Dependent Plasticity in the Amygdala and Fragile X Syndrome"
|8:20 pm - 8:30 pm||Discussion|
|8:30 pm - 8:50 pm||Rachel Sare (National Institute of Mental Health, NIH, USA)|
"Long-Term Effects of Chronic Sleep Restriction on Behavior in Fmr1 KO Mice"
|8:50 pm - 9:00 pm||Discussion|
|9:00 pm - 9:20 pm||Margaret King (Geisinger Health System, USA)|
"Heritable Quantitative Traits and Implications for the Study of Phenotypic Heterogeneity in Fragile X Syndrome"
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Identification and Investigation of New Therapeutic Targets|
|Discussion Leader: Margaret King (Geisinger Health System, USA)|
|9:00 am - 9:20 am||Ellen Hoffman (Yale University, USA)|
"High-Throughput Drug Discovery in Zebrafish Models of Autism Risk Genes"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Dawn Lammert (State University of New York Upstate Medical University, USA)|
"RELN Mutations Identified in Autism Spectrum Patients Cause a Protein Biosynthetic Defect"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Amit Modgil (Tufts University, USA)|
"Neurosteroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Elizabeth Berry-Kravis (Rush University Medical Center, USA)|
"An Update on Fragile X Clinical Trials"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: Translating Basic Research into the Clinic|
|A panel of experts composed of academic investigators, clinicians and funding agencies will be discussing recent progress and difficulties of taking basic research into the clinic.|
|Discussion Leader: Sally Till (University of Edinburgh, United Kingdom)|
|1:30 pm - 2:30 pm||Panel Discussion|
|"Translating Basic Research into the Clinic"|
- Elizabeth Berry-Kravis (Rush University Medical Center, USA)
- Christina Gross (Cincinnati Children's Hospital Medical Center, USA)
- Laura Mamounas (National Institute of Neurological Disorders and Stroke, NIH, USA)
- Paul Wang (Autism Speaks, USA)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Funding for this conference was made possible (in part) by 1R13 HD088062-01 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.