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Intrinsically Disordered Proteins (GRS)
Gordon Research Seminar

Function Through Disorder: Intrinsically Disordered Proteins in Biology and Medicine

Dates

June 25-26, 2016

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chairs:
Rebecca B. Berlow & Ofrah Faust

Meeting Description

The Gordon Research Seminar on Intrinsically Disordered Proteins is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The second IDP GRS will focus on emerging and evolving ideas regarding the involvement of disordered proteins in critical cellular processes. We will discuss the fundamental properties of IDPs, recent advances in methods used to characterize IDPs, and the many roles of IDPs in normal cellular function and disease.

The GRS will provide junior scientists a venue to present, discuss, and receive feedback on their research, expand their knowledge of established principles as well as relevant pending questions in the field, and promote interactions and constructive networking with successful established scientists as well as with their peers. The meeting will conclude with a mentoring session led by experienced researchers who will offer their perspectives and advice on establishing independent research careers and the associated challenges and rewards of careers in science.

We encourage applications from both those familiar with the field as well as those for whom IDPs are a new topic of interest, to promote discussion and exchange of ideas to drive this exciting area of research forward.

Related Meeting

This GRS was held in conjunction with the "Intrinsically Disordered Proteins" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmCharacterizing IDPs by Computational Approaches
Discussion Leaders: M. Madan Babu (MRC Laboratory of Molecular Biology, United Kingdom) and Shrutidhara Biswas (Indian Institute of Technology Guwahati, India)
3:15 pm - 3:30 pmAlex Holehouse (Washington University in St. Louis, USA)
"The Sequence Determinants of Phase Separation via Complex Coacervation in IDPs"
3:30 pm - 3:35 pmDiscussion
3:35 pm - 3:50 pmMainak Guharoy (VIB, Vrije Universiteit Brussel, Belgium)
"The Tripartite Degron Model: Structural Disorder in the Control of Cellular Networks by Programmed Protein Degradation"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmRedefining the Structure-Function Paradigm
Discussion Leaders: Assaf Friedler (The Hebrew University of Jerusalem, Israel) and Cesar Cuevas-Velazquez (Universidad Nacional Autónoma de México, Mexico)
5:30 pm - 5:50 pmEleanor Dickinson (University of Manchester, United Kingdom)
"Let's Twist Again: Modulation of p53 N-Terminal Structure and Function with Varying Helicity"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmAna Melo (University of Pennsylvania, USA)
"Exploring the Conformational Plasticity of Tau: Insights into Function and Dysfunction"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmKaitlyn Gerhart (Georgetown University, USA)
"Self-Interaction of the Intrinsically Disordered c-Myc Oncoprotein"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmEric Gibbs (Pennsylvania State University, USA)
"Investigating the Structural Basis for the CTD Code"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amExploring the Functional Diversity of IDPs
Discussion Leaders: Ashok Deniz (The Scripps Research Institute, USA) and Iker Valle Aramburu (European Molecular Biology Laboratory (EMBL), Germany)
9:00 am - 9:20 amVirginia Burger (Massachusetts Institute of Technology, USA)
"A Bacterial Antitoxin's Conformational Ensemble Provides Insight into Distinct Functional Roles of Its Distinct Disordered States"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amErik Martin (St. Jude Children's Research Hospital, USA)
"Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and Upon Multi-Site Phosphorylation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAnne Bremer (Max Planck Institute of Molecular Plant Physiology, Germany)
"Structural and Functional Characterization of Three Closely Related Intrinsically Disordered LEA Proteins from Arabidopsis thaliana"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amShana Elbaum (Princeton University, USA)
"From Fluids to Fibers: Liquid Phase Separation and Aggregation of Disordered Proteins"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: K. Aurelia Ball (University of California, San Francisco, USA)
1:30 pm - 2:30 pmPanel Discussion
"Careers in Scientific Research"
  • Monika Fuxreiter (University of Debrecen, Hungary)
  • Elizabeth Rhoades (University of Pennsylvania, USA)
  • Philipp Selenko (FMP Berlin, Germany)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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