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Lymphatics (GRS)
Gordon Research Seminar

Perspectives on Lymphatic Vascular Signaling, Development and Function

Dates

March 19-20, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chairs:
Amelie Sabine & Joshua P. Scallan

Meeting Description

The Gordon Research Seminar on Lymphatics is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The 2016 Lymphatics GRS will focus on new advances in research on the regulation of lymphatic vascular network development and function. We will discuss mechanisms involved in establishing a functional lymphatic vasculature, its role in several physiological processes such as metabolism and immunity, and its implication in pathologies such as lymphedema or cancer.

This seminar will provide young scientists with a privileged environment for scientific exchanges, networking and career guidance.

Related Meeting

This GRS was held in conjunction with the "Lymphatics" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Exploring the Lymphatics, Follow the Guide!
Opening lecture by an expert internationally recognized in the Lymphatics field for his core accomplishments.
Discussion Leader: Amelie Sabine (University of Lausanne, Switzerland)
3:45 pm - 4:15 pmDontscho Kerjaschki (Medical University of Vienna, Austria)
"Lymphangiogenesis and Renal Transplant Tolerance"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTargeting Lymphatic Function for Potential Therapies
Discussion Leaders: Joshua Scallan (University of South Florida, USA) and Maike Frye (Uppsala University, Sweden)
7:30 pm - 7:45 pmMaximilian Nitschke (University of California, San Francisco, USA)
"Cause and Consequences of Chylothorax Formation in a Mouse Model of Adipocyte-Specific VEGF-C Overexpression"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmTimothy Norman (Boston University School of Medicine, USA)
"Origin and Maturation of Pulmonary Lymphatic Endothelial Cells"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmSamia Bachmann (ETH Zurich, Switzerland)
"In Vivo Regulation of Lymphatic Vessel Function by the Autonomic Nervous System"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmScott Zawieja (University of Missouri, USA)
"The Ca2+-Activated Cl- Channel TMEM16A (ANO1) Modulates Stretch Sensitive Chronotropy in Mouse Collecting Lymphatic Vessels"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSamira Jamalian (Imperial College London, United Kingdom)
"Lymphatic Suction Pressure in Collecting Lymphatic Vessels"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmLi-Hao Huang (Washington University School of Medicine in St. Louis, USA)
"Novel Approaches to Study High-Density Lipoprotein Transport from Tissues"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNew Lymphatic Regulators in Mouse and Fish
Discussion Leaders: Kaska Koltowska (Institute for Molecular Bioscience, University of Queensland, Australia) and Jeremiah Bernier-Latmani (University of Lausanne, Switzerland)
9:00 am - 9:15 amYvonne Padberg (Institute for Cardiovascular Organogenesis and Regeneration, University of Münster, Germany)
"Novel and Essential Gene Functions that Govern Lymphatic Formation in Zebrafish and Mice"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amAjit Muley (Columbia University, USA)
"Notch and MMPs: Functional Partners in Guiding Lymphatic Development?"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amEnyuan Cao (Monash University, Australia)
"Targeting Intestinal Lymphatic Lymphocytes: A Potential Route to Treat Immune-Metabolic Diseases"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amHung Bui (University of Pennsylvania, USA)
"Proteolytic Activation by ADAMTS3 Defines Distinct Mechanisms of Lymphangiogenesis Mediated by VEGFC and VEGFD"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSebastien Gauvrit (Max Planck Institute for Heart and Lung Research, Germany)
"A New Role for the Transcription Factor Hhex During Lymphangiogenesis in Zebrafish and Mouse"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amXiaolei Liu (Northwestern University, USA)
"Rasip1 in Lymphatic Morphogenesis"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmLymphatics in Pathologies
Discussion Leaders: Ying Yang (University of South Florida, USA) and Aleksanteri Aspelund (University of Helsinki / Wihuri Research Institute, Finland)
1:30 pm - 1:45 pmMirela Berisa (Icahn School of Medicine at Mount Sinai, USA)
"Lymphatic Endothelium Exerts Antioxidant Activity and Protects Breast Cancer Cells from Apoptosis"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmChi Nguyen (University of Vienna, Austria)
"12(S)-HETE and Lymph Node Metastasis: Its Generation in MDA-MB231 Breast Cancer Cells and Its Signaling in Lymphendothelial Cells"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmAntoine Louveau (University of Virginia, USA)
"Role of the Meningeal Lymphatic Vasculature in the Development and Maintenance of Experimental Autoimmune Encephalomyelitis"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1 R13 DK 109553 - 01 from NIDDK, NIAD and NHLBI. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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