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Musculoskeletal Biology & Bioengineering (GRS)
Gordon Research Seminar

Moving Forward in Musculoskeletal Biology and Bioengineering: New Approaches from Diverse Disciplines

Dates

August 6-7, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chairs:
Megan L. Killian & Anne M. Gingery

Meeting Description

The Gordon Research Seminar on Musculoskeletal Biology and Bioengineering is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. Musculoskeletal biology and bioengineering incorporates many areas of research, including but not limited to stem cell biology, developmental biology, molecular genetics, bioengineering, materials science, computation biology and modeling, and ultimately clinical and translational medicine.

The focus of this meeting includes providing early career investigators (graduate students, postdoctoral fellows, and junior faculty) an opportunity to build networks and expand their programs, fostering interactions and development of connections with other early investigators, providing opportunities for early career researchers to present their work, enabling participants to explore and learn about novel career options, and promoting the seamless transition of GRS participants to active and engaged participation in the full GRC program that follows.

Related Meeting

This GRS was held in conjunction with the "Musculoskeletal Biology & Bioengineering" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Interdisciplinary Approaches to Musculoskeletal Research
The goal of this session is to introduce early investigators to the Gordon Conference and the theme of both the GRS and the GRC to come. In particular our meeting focus (Moving Forward in Musculoskeletal Biology and Bioengineering) will introduce and develop the concept of cross-disciplinary studies, networking and strategies for early investigators to develop strong and meaningful research careers and programs. A Keynote Lecture will be presented by Dr. Ronen Schweitzer of the Oregon Health Sciences University and Dr. Alice Huang of Mount Sinai. Drs. Schweitzer and Huang will discuss their career paths in biology and engineering, respectively, their interdisciplinary research programs, and the role that mentorship has played in their careers.
Discussion Leaders: Anne Gingery (Mayo Clinic, USA) and Megan Killian (University of Delaware, USA)
3:45 pm - 4:00 pmRonen Schweitzer (Shriners Research Center, Portland, USA)
"Of Flies and Mice, Biologists and Engineers - A Tendon Story"
4:00 pm - 4:05 pmDiscussion
4:05 pm - 4:20 pmAlice Huang (Icahn School of Medicine at Mount Sinai, USA)
"Integrating Developmental Biology and Tissue Engineering Approaches for Tendon Regeneration"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMusculoskeletal Crosstalk (and Beyond)
Discussion Leaders: Oliver Gardner (Boston Children's Hospital, USA) and Rachel Nordberg (University of North Carolina at Chapel Hill / North Carolina State University, USA)
7:30 pm - 7:45 pmNeta Felsenthal (Weizmann Institute of Science, Israel)
"Development on the Move: Population Replacement in Migrating Entheses"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmGeorg Feichtinger (University of Leeds, United Kingdom)
"Novel, Multi-Phasic Gene-Activated Matrices for Gradient-Based Multi Gene Delivery"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmRiccardo Gottardi (University of Pittsburgh, USA)
"An Osteochondral Microphysiological System to Study Cartilage-Bone Interaction in Native Tissues and Engineered Model Constructs"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmJakob Sieker (Boston Children's Hospital, Harvard Medical School, USA)
"Loss of Articular Cartilage Glycosaminoglycans in Post-Traumatic Osteoarthritis Is Associated with the Activation of Pathways Related to Cartilage and Bone Formation in the Synovium"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmClaire McLeod (University of Pennsylvania, USA)
"Single-Cell Molecular and Microenvironmental Heterogeneity in Differentiating Stem Cells"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJennifer Robinson (Columbia University, USA)
"Estrogen Promotes Chondrogenesis and Maintains Homeostasis in the Temporomandibular Joint Fibrocartilage via Estrogen Receptor Alpha"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMusculoskeletal Injury and Strategies for Repair
Discussion Leaders: Bashar Alkhatib (University of Alabama at Birmingham, USA) and David Browe (Trinity College Dublin, Ireland)
9:00 am - 9:15 amKaren Bulaklak (The University of North Carolina at Chapel Hill, USA)
"Defining the Role of microRNA-206 in Duchenne Muscular Dystrophy"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amAlvin Wong (University of California, San Francisco, USA)
"The Effect of Motor Denervation on Muscle Satellite Cells"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amBrian Diekman (University of North Carolina at Chapel Hill, USA)
"Transcriptional Regulation of the Aging Biomarker p16INK4a and Its Role in Mediating Chondrocyte Senescence During Osteoarthritis"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amGrainne Cunniffe (Trinity College Dublin, Ireland)
"Cartilage ECM Derived Biomaterials for Joint Regeneration"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amJulianne Huegel (University of Pennsylvania, USA)
"Effects of Autologous Tenocyte-Seeded Nanofibrous Scaffolds in Rotator Cuff Repair Are Age-Dependent"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amRose Long (Mount Sinai Hospital, USA)
"Induction of Cd146+ Phenotype by Tgfb1 from Human Annulus Fibrosus Cells for Annulus Repair"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
This session will provide of forum for early career investigators to discuss career options and paths, including Academia, National Laboratories, the NIH, Clinical Practice, and Industry.
Discussion Leader: Dana Cairns (Tufts University, USA)
1:30 pm - 2:30 pmPanel Discussion
"Panel Discussion Career Options and Paths, Including Academia, National Laboratories, the NIH, Clinical Practice, and Industry"
  • Louis Defrate (Duke University Medical Center, USA)
  • Peter Johnson (MedSurgPI, LLC, USA)
  • Yasaman Shirazi (NASA Ames Research Center, USA)
  • Fei Wang (National Institutes of Health, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by (1R13AR070005-01) from the National Institute of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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