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Neurobiology of Brain Disorders (GRS)
Gordon Research Seminar

Neurodegenerative Disease: New Directions in Synaptic Dysfunction and Cell Biology

Dates

August 6-7, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chairs:
Courtney E. Lane-Donovan & Lorena Saelices Gomez

Meeting Description

The Gordon Research Seminar on Neurobiology of Brain Disorders is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

At this meeting, we will discuss emerging themes in neurodegeneration and related neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. This meeting will bring together students, postdocs, and early investigators researching a wide variety of topics, including synaptic dysfunction, cell biology, trafficking, protein degradation, and endocytosis. The seminar will conclude with a mentorship panel on career paths related to neurodegeneration.

Related Meeting

This GRS was held in conjunction with the "Neurobiology of Brain Disorders" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmSynaptic Dysfunction in Neurodegeneration
Discussion Leader: Maj-Linda Selenica (USF Health Byrd Alzheimer's Institute, USA)
3:15 pm - 3:20 pmOpening Remarks
3:20 pm - 3:35 pmSara Calafate (Janssen Pharmaceutica / Vlaams Instituut voor Biotechnologie (VIB), KU Leuven, Belgium)
"Synaptic Modulation of Tau Pathology Propagation"
3:35 pm - 3:40 pmDiscussion
3:40 pm - 3:55 pmCheng Fang (Boston University, USA)
"Neuronal System to Detect Prion Toxicity"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCell Biology of Neurodegeneration: Toxic Species, Endocytosis, Trafficking, and Degradation
Discussion Leaders: Marc Aurel Busche (Technical University of Munich, Germany) and Tatyana Shelkovnikova (Cardiff University, United Kingdom)
5:30 pm - 5:50 pmDaniela Papadia (Karolinska Institutet, Sweden)
"A Neuroprotective Role for Insulin and Pyruvate in Energy Compensatory Mechanisms"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmHermien Acx (Vlaams Instituut voor Biotechnologie (VIB), KU Leuven, Belgium)
"Accumulation of APP CTFs: Not the Cause of Neurodegeneration in Gamma-Secretase KO Mice"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmTheresa Pohlkamp (University of Texas Southwestern Medical Center, USA)
"Reelin and EphB/Ephrin-B Interplay: Neuronal Migration or Synaptic Plasticity?"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmSmriti Sangwan (University of California, Los Angeles, USA)
"Structure Guided Approach Reveals the Basis of Neurotoxicity in ALS"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amTranslational Applications
Discussion Leader: Maria-Belen Lopez (Institut du Cerveau et de la Moelle Épinière / INSERM U1127, France)
9:00 am - 9:20 amMarie Bordone (Instituto de Medicina Molecular, Universidade de Lisboa, Portugal)
"Going Deep in the Brain with Alternative Splicing in Parkinson's Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amVishal Jain (Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organisation, India)
"Neuronal Release of Alpha-Synuclein During Hypoxia Causes Neuroinflammation and Exacerbates Neurodegeneration Through Mac1/NOX2 Pathway"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amLisa McGinley (University of Michigan, USA)
"Human Neural Stem Cells Improve Cognition and Disease Pathology in the APP/PS1 Alzheimer's Mouse Model"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amTien-Phat Huynh (Washington University School of Medicine, USA)
"Use of Anti-Sense Oligonucleotides: An Approach to Knock Down APOE in the Adult Brain"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Pathways to Success in Neurobiology
Discussion Leaders: Courtney Lane-Donovan (University of Texas Southwestern Medical Center, USA) and Lorena Saelices Gomez (University of California, Los Angeles, USA)
1:30 pm - 2:30 pmPanel Discussion
"Pathways to Success in Neurobiology"
  • Robert Finkelstein (National Institute of Neurological Disorders and Stroke, NIH, USA)
  • David Holtzman (Washington University in St. Louis, USA)
  • Joachim Herz (University of Texas Southwestern Medical Center, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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