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Notch Signaling in Development, Regeneration & Disease (GRS)
Gordon Research Seminar

Notch Signaling During Development, Adult Stage Tissue Maintenance, and Disease

Dates

July 30-31, 2016

Location

Bates College
Lewiston, ME

Organizers

Chairs:
Mustafa Turkoz & Rolake Alabi

Meeting Description

This will be the second Gordon Research Seminar (GRS) on Notch Signaling in Development, Regeneration & Disease for young scientists. Notch GRS meetings are organized by young scientists with the support of leading scientists from the associated Notch GRC. This unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education will be an outstanding opportunity for young scientists to present and exchange new data and cutting edge ideas.

In this second Notch GRS, we will focus on the role of Notch signaling during development, adult stage tissue maintenance, and disease. The scope will span from model organisms to humans and will integrate biochemical, cell biological, structural and bioinformatic approaches. All applicants from diverse scientific and medical fields of Notch signaling are welcome to attend this meeting to exchange ideas and data, and to facilitate the translation of basic knowledge into clinical settings such as cancer therapeutics and regenerative medicine.

Related Meeting

This GRS was held in conjunction with the "Notch Signaling in Development, Regeneration & Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Notch1-Induced T-Cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL)
Discussion Leader: Mustafa Turkoz (Cincinnati Children's Hospital Medical Center, USA)
3:45 pm - 4:15 pmJon Aster (Harvard Medical School / Brigham and Women's Hospital, USA)
"Notch Signaling in Cancer: Trials and Tribulations on the Road to Therapy"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Mechanisms of Notch Signaling
Discussion Leaders: Michael Schneider (Stony Brook University, USA), Kumiko Kobayashi (Institute for Virus Research, Kyoto University, Japan) and Stephen Blacklow (Harvard Medical School, USA)
7:30 pm - 7:45 pmVincent Luca (Stanford University School of Medicine, USA)
"Structure and Engineering of Notch-Ligand Interactions"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmLena Tveriakhina (Hannover Medical School, Germany)
"Characterization of the Functional Divergence of the Mouse Notch Ligands DLL1 and DLL4"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmPreetish Kadur Lakshminarasimha Murthy (Cornell University, USA)
"Fringe Mediated Modification of Notch Ligands in the Intestine"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmHiromi Shimojo (iCeMS, Kyoto University, Japan)
"Oscillatory Control of Delta-Like1 in Cell Interactions Regulates Dynamic Gene Expression and Tissue Morphogenesis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmVivek Kumar (Albert Einstein College of Medicine, USA)
"Fringe-Regulated Notch Signaling in T and B Cell Development"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmKaden Southard (University of California, San Francisco, USA)
"Regulation of Notch Signaling at the Cell Surface Through Receptor Spatial Organization"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNotch Signaling in Development, Homeostasis, Stem Cell Maintenance and Disease
Discussion Leaders: Whitney Edwards (University of Illinois at Urbana Champaign, USA), Katrina Slemmons (Duke University, USA) and Warren Pear (University of Pennsylvania, USA)
9:00 am - 9:15 amAnna Engler (University of Basel, Switzerland)
"Differential Roles of Notch1 and Notch2 Signaling in Adult Neurogenesis"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amDaniel Lafkas (Genentech Inc., USA)
"Therapeutic Antibodies Reveal Notch Control of Transdifferentiation in the Adult Lung"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amGregory Farber (Weill Cornell Medical College, USA)
"Role of the ADAM10/Notch Signaling Pathway in the Development of the Glomerular and Epicardial Vasculature"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amRussell Ryan (Massachusetts General Hospital, USA)
"Activation of Oncogene Enhancers by Notch Signaling in Small B Cell Lymphomas"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amNatacha Bohin (University of Michigan, USA)
"Notch and mTORC1 Regulate the Intestinal Epithelial Regenerative Response"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amQing Wang (University of Michigan, USA)
"The Direct Notch1 Cofactor Zmiz1 Switches from Repressing to Activating Notch1 Signals upon T-Lineage Commitment"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Paths in the Notch Signaling World
Discussion Leader: Rolake Alabi (Weill Cornell Medical College, USA)
1:30 pm - 2:30 pmPanel Discussion
"Career Paths in the Notch Signaling World"
  • Carl Blobel (Hospital for Special Surgery, Weill Cornell Medicine, USA)
  • Sarah Bray (University of Cambridge, United Kingdom)
  • Judith Kimble (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA)
  • Ivan Maillard (University of Michigan, USA)
  • Christian Siebel (Genentech, Inc., USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD088000. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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