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Post-Transcriptional Gene Regulation (GRS)
Gordon Research Seminar

Discoveries for the Future of RNA Biology

Dates

July 9-10, 2016

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chairs:
Melanie A. Preston & Aimee L. Jalkanen

Meeting Description

The 2016 Gordon Research Seminar (GRS) on Post-Transcriptional Gene Regulation is a unique forum where early-career scientists can discuss cutting-edge data and new ideas in the field of RNA control. This meeting aims to provide an opportunity for graduate students, post-doctoral researchers, and other young investigators to network, establish collaborations, and interact with senior investigators from the associated Gordon Research Conference, which takes place directly after the GRS. To underscore the importance of early career scientists as the next generation of leading scientists, the 2016 GRS theme is "Discoveries for the Future of RNA Biology". An important goal of the meeting is to offer a setting for professional development in addition to scientific discussion. GRS and GRC attendees from all over the globe will represent academia, industry, and government, providing young investigators the chance to explore a variety of potential future careers in an approachable atmosphere.

The 2016 GRS will focus on RNA-mediated gene regulation, specifically genome-wide control of expression, RNA modifications, regulatory RNAs, non-coding RNAs, and RNA-focused avenues for disease therapeutics. The meeting will have a keynote speaker and approximately 10 research talks chosen from abstract submissions describing unpublished research at the forefront of RNA biology. In addition, two poster sessions will enable all participants to present their research and receive valuable feedback from their peers. The overall tone of the meeting will be relaxed and collegial, with the goal of providing an atmosphere where young scientists are comfortable discussing their work and sharing innovative ideas.

Related Meeting

This GRS was held in conjunction with the "Post-Transcriptional Gene Regulation" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmRNA Modifications: From m6A to Poly(A)
Discussion Leader: Aimee Jalkanen (Colorado State University, USA)
3:45 pm - 4:00 pmCarter Takacs (Yale University, USA)
"Deciphering the Regulatory Code Underlying mRNA Stability in the Early Embryo"
4:00 pm - 4:05 pmDiscussion
4:05 pm - 4:20 pmIan Roundtree (University of Chicago, USA)
"N6-Methyladenosine Promotes Nuclear Processing and Export of Messenger RNA"
4:20 pm - 4:25 pmDiscussion
4:25 pm - 4:30 pmGeneral Discussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: The Future of Biomedical Research / Genome-Wide Coordination of RNA Regulation
Discussion Leaders: Melanie Preston (Promega Corporation / University of Wisconsin-Madison, USA) and Wayne Miles (Harvard Medical School / Massachusetts General Hospital Cancer Center, USA)
7:30 pm - 8:00 pmJon Lorsch (National Institute of General Medical Sciences, NIH, USA)
"Developing a More Efficient and Sustainable Biomedical Research Enterprise for the Next Generation of Scientists"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmMichael Fisher (Rutgers New Jersey Medical School, USA)
"The mRNA-Protein Interactome Coordinates Post-Transcriptional Regulation in Trypanosoma brucei"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmChristopher Lapointe (University of Wisconsin-Madison, USA)
"A Higher Order mRNA Regulatory Network Revealed by RNA Tagging"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmSrivats Venkataramanan (University of California, Los Angeles, USA)
"A Novel Mechanism of Splicing Regulation by the Chromatin-Remodeling Complex Swi/Snf as an Effector of Cellular Decision-Making in Response to Environmental Cues"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amRegulatory RNAs and Non-Coding RNAs / Mentorship Component: Career Panel
Discussion Leader: Marta Mele (Harvard University, USA)
9:00 am - 9:15 amAlexandra McCorkindale (Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Germany)
"Regulatory Roles of Non-Coding RNAs During Embryonic Neurogenesis in Drosophila"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amEesha Sharma (University of Toronto, Canada)
"Global Mapping of the Human RNA-RNA Interactome Reveals New Functions for Non-Coding RNAs"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amWen Chiy Liew (Institute of Medical Biology, A*STAR, Singapore)
"Loss of miR-335 in Atopic Dermatitis Leads to Defective Barrier Function"
9:55 am - 10:00 amDiscussion
10:00 am - 11:00 amPanel Discussion
"RNA Biology Builds Bridges to Your Future Career"
  • Brenton Graveley (UConn Health, USA)
  • Katie Mouzakis (Fort Lewis College, USA)
  • Shruti Waghray (Ionis Pharmaceuticals, USA)
  • Jeremy Wilusz (University of Pennsylvania, USA)
  • Jon Lorsch (National Institute of General Medical Sciences, NIH, USA)
  • Melanie Preston (Promega Corporation / University of Wisconsin-Madison, USA)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmRNA: A Gateway into Disease Therapeutics
Discussion Leader: Boxuan Zhao (University of Chicago, USA)
1:30 pm - 1:45 pmAthma Pai (Massachusetts Institute of Technology, USA)
"Widespread Shortening of 3' UTRs and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Response to Infection"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmRakesh Chatrikhi (University of Rochester, USA)
"A Myelodysplasia-Relevant S34F Mutation of the U2AF1 Pre-mRNA Splicing Factor Alters RNA Recognition"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmRosaura Esteve-Puig (University of California, San Francisco, USA)
"Long Noncoding RNA as a Potential Target in Drug Resistant Melanomas"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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