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Spirochetes, Biology of (GRS)
Gordon Research Seminar

Spirochete Diversity and Pathogenesis: Spanning the Globe

Dates

January 9-10, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Robert B. Lochhead & Azad Eshghi

Meeting Description

The Gordon Research Seminar on the Biology of Spirochetes is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. This is an interactive meeting, so all participants are required to submit an abstract.

We are spanning the globe to bring you the constant variety of spirochete biology, pathogenesis, and research. This meeting will feature a keynote address by Dr. Alan Barbour; a career development session with panelists from funding agencies, academia, government, and industry; and presentations by graduate students and post-docs, the ones on the front lines of spirochete research! Join us as we explore the wide world of spirochetes!

Related Meeting

This GRS was held in conjunction with the "Spirochetes, Biology of" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: The Wide World of Spirochetes
Discussion Leaders: Brandon Jutras (Howard Hughes Medical Institute / Yale University, USA) and Hannah Wilder (Baylor College of Medicine, USA)
3:45 pm - 3:50 pmIntroduction by Discussion Leader
3:50 pm - 4:20 pmAlan Barbour (University of California, Irvine, USA)
"Borrelia: A Mirror to Host Immunity"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDiversity of Spirochete Virulence and Adaptation
Discussion Leaders: Elsio Wunder (Yale School of Public Health, USA) and Philip Adams (University of Central Florida College of Medicine, USA)
Diversity of Spirochete Virulence
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:50 pmKristel Lourdault (University of California, Los Angeles / VA Greater Los Angeles Healthcare System, USA)
"Using Tn-Seq to Identify Novel Leptospira interrogans Virulence Factors"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmTrever Smith (The University of Texas at San Antonio, USA)
"Borrelia Host-Adaptation Protein (BadP) Contributes to the Virulence of the Agent of Lyme Disease"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmKaren Lithgow (University of Victoria, Canada)
"Molecular Mechanisms for the Treponema pallidum Protein Pallilysin (Tp0751) in Adhesion to the Vascular Endothelium"
8:25 pm - 8:30 pmDiscussion
Diversity of Spirochete Adaptation
8:30 pm - 8:35 pmIntroduction by Discussion Leader
8:35 pm - 8:50 pmJae Min Shin (University of Michigan School of Dentistry, USA)
"Treponema denticola in Oral Biofilms"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmHaritha Adhikarla (Yale University, USA)
"A Novel Dyad of Sensor Histidine Kinases, Lgr, Serves as a Global Regulator of Expression and Governs Virulence and Environmental Adaptation for the Leptospira Pathogen"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAshley Groshong (University of Connecticut Health Center, USA)
"Redundancy and Precision for Amino Acid Acquisition: Evaluation of the Oligopeptide System in Borrelia burgdorferi"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amDiversity of Spirochete Pathogenesis and Frontiers in Spirochete Research
Discussion Leaders: Sarah Whiteside (University of Utah, USA) and Christopher Pappas (Manhattanville College, USA)
Diversity of Spirochete Pathogenesis
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:20 amKlemen Strle (Massachusetts General Hospital, Harvard Medical School, USA)
"Differences Between European and North American Strains of Borrelia Species in Lyme Borreliosis Severity and Disease Manifestation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amKelly Hawley (University of Connecticut Health Center, USA)
"Human Macrophage Polarization Enhances Opsonophagocytosis and Inflammatory Response to the Stealth Pathogen, Treponema pallidum"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amAnnukka Pietikainen (University of Turku, Finland)
"Studies on Dissemination of Lyme Borreliosis in Mice Using Positron Emission Tomography/Computed Tomography (PET/CT) Imaging"
9:55 am - 10:00 amDiscussion
Frontiers in Spirochete Research
10:00 am - 10:05 amIntroduction by Discussion Leader
10:05 am - 10:20 amDhruv Vig (Johns Hopkins University, USA)
"Modeling Lyme Disease: From Single Cell to Pathogen-Host Interactions"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amMartin Strnad (Biology Centre CAS, Czech Republic)
"Correlative Cryo-Fluorescence and Cryo-Scanning Electron Microscopy as a Straightforward Tool to Study Host-Pathogen Interactions"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amRhodaba Ebady (University of Toronto, Canada)
"A Catch Bond Mechanism Promotes Bacterial Vascular Interactions Under Hydrodynamic Flow"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Development Panel
Discussion Leaders: Brian Leydet (Trudeau Institute, USA) and Brandee Stone (University of North Dakota, USA)
1:30 pm - 1:35 pmIntroduction by Discussion Leader
1:35 pm - 2:30 pmPanel Discussion
"Finding Your Way in the Wide World of Spirochete Research"
  • Brandon Jutras (Howard Hughes Medical Institute / Yale University, USA)
  • Martin Kintrup (Viramed Biotech AG, Germany)
  • Claudia Molins (Centers for Disease Control and Prevention, USA)
  • Samuel Perdue (National Institute of Allergy and Infectious Diseases, NIH, USA)
  • Steven Projan (MedImmune, USA)
  • Patricia Rosa (Rocky Mountain Labs / National Institute of Allergy and Infectious Diseases, NIH, USA)
  • Christopher Pappas (Manhattanville College, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13AI122289-01 from the National Institute of Allergy and Infections Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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