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Alcohol & the Nervous System
Gordon Research Conference

Breakthroughs in Alcohol Neuroscience Research at the Level of Molecules, Cells, Synapses, and Behavior

Dates

February 7-12, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Dorit Ron

Vice Chairs:
Jeff L. Weiner & C. Fernando Valenzuela

Meeting Description

The 2016 Gordon Research Conference (GRC) on Alcohol and the Nervous System: Molecules, Cells, Circuits and Behavior will provide a unique forum to bring together a diverse range of young and established alcohol researchers, and experts in complementary fields. The conference will cover a broad range of studies at the molecular, cellular, circuit/systems and behavioral level, with particular emphasis on multidisciplinary work and innovative approaches. Talks will address questions centered on the neural substrates that contribute to alcohol-related health disorders across the entire lifespan and will include systems ranging from nematodes to humans. Participation by young investigators will be strongly emphasized. The central goals of the conference are to: 1) Foster deep and open discussion of groundbreaking research at the forefront of alcohol effects on the nervous system and related neuroscience areas. 2) To highlight cutting edge neuroscience techniques that facilitate discovery of brain mechanisms driving alcohol drinking and abuse and those involved in fetal alcohol spectrum disorders. 3) To promote interaction between young and senior investigators and the exchange of ideas that will shape future directions of alcohol neuroscience research. 4) To foster the development of the next generation of alcohol researchers by encouraging participation of students and postdoctoral fellows. 5) To recruit scientists from related research areas to the alcohol addiction field by promoting and fostering new collaborations. The format will provide ample time for formal and informal discussions and emphasize the presentation of unpublished data, thus ensuring that the newest and most exciting developments in the field are discussed. Poster presentations will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from submitted abstracts for "late-breaking topic" talks by young investigators and Karl Deisseroth from Stanford University will be the keynote speaker.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Optogenetics and the Next Generation of Circuit Analysis
Discussion Leader: David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
7:40 pm - 8:00 pmIntroduction by Discussion Leader
8:00 pm - 9:00 pmKarl Deisseroth (Stanford University, USA)
"Integrated Brainwide Structural and Functional Analysis"
9:00 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThe Dark Side of Addiction
Discussion Leader: Howard Becker (Medical University of South Carolina, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amGeorge Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Neuroplasticity in the Brain Stress Systems in Alcoholism"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJeff Weiner (Wake Forest School of Medicine, USA)
"Mesolimbic Adaptations Underlying the Comorbidity Between Anxiety Disorders and Alcoholism"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSelected from Poster Abstracts: Elizabeth Burnett (Medical University of South Carolina, USA)
"The Role of the Rostromedial Tegmental Nucleus in Ethanol Withdrawal and Negative Affect"
10:20 am - 10:25 amDiscussion
10:25 am - 10:40 amOlivier George (Scripps Research Institute, USA)
"Pharmacogenetic and Optogenetic Control of Alcohol Dependence Through Inactivation of a Withdrawal Neuronal Ensemble in the Central Amygdala"
10:40 am - 10:45 amDiscussion
10:45 am - 11:00 amCoffee Break
11:00 am - 11:20 amKlaus Miczek (Tufts University, USA)
"CRF-Dopamine in the VTA Is Critical for Stress-Escalated Alcohol and Stimulant Self-Administration"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amYavin Shaham (National Institute on Drug Abuse, Intramural Research Program, NIH, USA)
"Context-Induced Relapse to Alcohol Seeking After Punishment-Imposed Abstinence: Behavioral and Neuronal Mechanism"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Gregory Rompala (University of Pittsburgh, USA)
"Paternal Chronic Variable Stress Reduces Ethanol Drinking Behavior Selectively in Male Offspring"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAre Ion Channels Key Molecular Substrates of Alcohol?
Discussion Leader: C. Fernando Valenzuela (University of New Mexico Health Sciences Center, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmPaul Slesinger (Icahn School of Medicine at Mount Sinai, USA)
"Molecular Actions of Alcohol on the G Protein-Gated Potassium Channel - So Simple Yet So Complex"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmNigel Atkinson (University of Texas at Austin, USA)
"Mechanism of Ethanol Tolerance: Gene Network Analysis in Flies"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAlex Dopico (The University of Tennessee Health Science Center, USA)
"Molecular Studies on the Effects of Alcohol on BK Channels"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmSelected from Poster Abstracts: Scott Hansen (The Scripps Research Institute, USA)
"Lipid-Gated Ion Channels and the Molecular Site of Ethanol Intoxication"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCircuitry of Motivated Behaviors
Discussion Leader: John Crabbe (Oregon Health Sciences University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amAntonello Bonci (National Institute on Drug Abuse, NIH, USA)
"An Optogenetic-Inspired Rtms Treatment for Cocaine Use Disorders"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amStephan Lammel (University of California, Berkeley, USA)
"Identifying Input-Specific Mechanisms Underlying Reward and Aversion in the Dopamine System"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amKevin Bender (University of California, San Francisco, USA)
"D3 Receptor Distribution and Function in Prefrontal Cortex"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amRoh-Yu Shen (University at Buffalo, USA)
"Developmental Ethanol Exposure Alters How Brain Reward Pathways Respond to Input Signals"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amJun Ding (Stanford University School of Medicine, USA)
"The Role of GABA Co-Release by Dopamine Neurons in Enhanced Alcohol Preference"
11:45 am - 11:50 amDiscussion
11:50 am - 12:10 pmSheena Josselyn (Hospital for Sick Children / University of Toronto, Canada)
"Manipulating a Rewarding Engram in Mice: Implications for Addiction"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNeuroscience Innovations for Alcohol Research
Discussion Leader: Changhai Cui (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmBruce Hope (National Institute on Drug Abuse, NIH, USA)
"Neuronal Ensembles in Addiction at the Moment"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmRobert Messing (The University of Texas at Austin, USA)
"A Crh-Cre Rat for Studying the Anatomy and Physiology of CRF Neurons"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmIan Slaymaker (Broad Institute, USA)
"CRISPR-Cas Systems for Genome Editing"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmCatherine Marcinkiewcz (University of North Carolina at Chapel Hill, USA)
"Chemogenetic Dissection of Aversive Circuits in the Brain"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Sophie Laguesse (University of California, San Francisco, USA)
"Prosapip1 - A Novel Mediator of Alcohol Abuse Disorder"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAlcohol and Decision Making
Discussion Leader: Kathleen Grant (Oregon Health and Science University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amJohn Woodward (Medical University of South Carolina, USA)
"Orbital Frontal Cortex and Its Role in Alcohol-Induced Behaviors"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amChristina Gremel (University of California, San Diego, USA)
"Orbitostriatal Gating of Decision Making"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amAbigail Schindler (University of Washington, USA)
"Identification and Pharmacological Reversal of a Selective Perturbation to Mesolimbic Circuitry that Promotes Maladaptive Decision Making After Adolescent Alcohol Use"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Zoe McElligott (University of North Carolina at Chapel Hill, USA)
"Central Amygdala Neurotensin Neurons Regulate Alcohol Consumption, Reward and Sedation"
10:25 am - 10:30 amDiscussion
10:30 am - 10:45 amCoffee Break
10:45 am - 11:05 amRita Goldstein (Mount Sinai School of Medicine, USA)
"Role of the mPFC in Extinction, Awareness and Risk Taking in Cocaine Addiction: MRI Studies"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amDavid Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Corticostriatal Mechanisms of Alcohol-Promoted Habitual Behavior"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmJonathan Brigman (The University of New Mexico, USA)
"Impact of Developmental Ethanol Exposure on Neural Circuits Mediating Decision Making"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Verginia Cuzon Carlson (Oregon Health and Science University, USA)
"Gestational Ethanol Exposure During the First Trimester Most Dramatically Decreases GABA Activity in the Dorsolateral Striatum of Mice"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmAddiction to Alcohol and Other Substances: Common Neural Substrates
Discussion Leader: Lawrence Judson Chandler (Medical University of South Carolina, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmJohn Dani (University of Pennsylvania, USA)
"Nicotinic and Stress-Related Mechanisms Boost Alcohol Self-Administration"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmDorit Ron (University of California, San Francisco, USA)
"Corticostriatal BDNF and Alcohol Drinking Behaviors"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmBrigitte Kieffer (McGill University, Canada)
"Commonalities in Protracted Abstinence to Drugs of Abuse?"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmSelected from Poster Abstracts: Vijay Ramchandani (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"A Human Experimental Model of Stress-Induced Alcohol Self-Administration: Influence of Binge Drinking History"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDrug Development - How Close Are We to a Cure for Alcohol Use Disorders?
Discussion Leader: Tamara Phillips (Oregon Health and Science University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amGunter Schumann (King's College London, United Kingdom)
"Developing Imaging Predictors and Neurobehavioral Phenotypes for Externalizing Disorders"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amJennifer Mitchell (University of California, San Francisco, USA)
"The Effects of Intranasal Oxytocin on Social Perception, Craving and Approach in Alcohol Abusers"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amBarbara Mason (The Scripps Research Institute, USA)
"Clinical Validation of the Stress Response as a Pharmacological Target for Treating Alcohol Dependence"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amSelected from Poster Abstracts: Anushree Karkhanis (Wake Forest School of Medicine, USA)
"Social Isolation Stress Mediates Changes in the Kappa Opioid Receptor System Function in the Nucleus Accumbens"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amLorenzo Leggio (National Institute on Alcohol Abuse and Alcoholism / National Institute on Drug Abuse, NIH, USA)
"Novel Targets for the Treatment of Alcohol Use Disorders: A Focus on the Gut-Liver-Brain Axis"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmJohn Krystal (Yale University School of Medicine, USA)
"Developing Pharmacotherapies for Alcoholism Based on the Interplay of Glutamate and Dopamine Signaling"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGene-Environment Interplay in Alcohol Actions
Discussion Leader: Michael Miles (Virginia Commonwealth University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmJoel Gelernter (Yale University School of Medicine, USA)
"Genetic Influences on Alcohol Dependence Risk from a Genomewide Perspective - Relationship to Population and Environmental Factors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmKim Raab-Graham (University of Texas at Austin, USA)
"Does Ethanol Act Like a Rapid Antidepressant?"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKazue Hashimoto-Torii (Children's National Medical Center, USA)
"Single Cell-Epigenetics in Motor Learning Deficit Elicited by Prenatal Alcohol Exposure"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmJill Bettinger (Virginia Commonwealth University, USA)
"A Role for SWI/SNF Chromatin Remodeling in Alcohol Phenotypes Is Conserved from C. Elegans to Humans"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number R13AA024639. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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