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Basal Ganglia
Gordon Research Conference

Emerging Views of Cellular and Circuit Diversity Within the Basal Ganglia

Dates

February 28 - March 4, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Nicole Calakos

Vice Chair:
Mark Bevan

Meeting Description

The basal ganglia are a collection of subcortical nuclei that are deeply embedded in widespread and diverse brain networks. Accordingly, the basal ganglia are involved in diverse processes ranging from movement to cognition. Yet, major questions remain concerning the specific contributions of basal ganglia circuitry to information processing and behavior. With recent technical advances in our ability to observe and perturb neuronal activity, views of basal ganglia circuitry and its contributions to brain function are evolving rapidly. In parallel, molecular and genetic advances are revealing molecular and cellular properties that could be targeted for therapeutic benefit. Indeed, basal ganglia dysfunction is involved in a number of clinically significant diseases such as Parkinson’s disease, Huntington’s disease, dystonia, Tourette’s syndrome, addiction and impulse control disorders. This conference will bring together scientists with diverse perspectives and approaches to discuss their latest discoveries, promote interaction and collaboration, and accelerate our understanding of the basal ganglia in health and disease.

Related Meeting

This GRC was held in conjunction with the "Basal Ganglia" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Striatal Adaptations in Parkinson's Disease: When Homeostasis Goes Astray
Discussion Leader: Nicole Calakos (Duke University Medical Center, USA)
7:40 pm - 9:00 pmD. James Surmeier (Northwestern University, USA)
"Striatal Adaptations in Parkinson's Disease: When Homeostasis Goes Astray"
9:00 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBasal Ganglia Circuit Interactions and the Behaviors They Shape
Discussion Leader: Thomas Wichmann (Emory University, USA)
9:00 am - 9:15 amHelen Bronte-Stewart (Stanford University, USA)
"Challenges and Opportunities for Modulating Basal Ganglia Circuitry: A Clinician's Perspective"
9:15 am - 9:20 amDiscussion
9:20 am - 9:40 amLaszlo Acsady (Hungarian Academy of Sciences, Hungary)
"Subcortical Control of Intralaminar Thalamic Activity"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amThomas Roseberry (University of California, San Francisco, USA)
"Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia"
10:05 am - 10:10 amDiscussion
10:10 am - 10:20 amMarcus Stephenson-Jones (Cold Spring Harbor Laboratory, USA)
"Action Outcomes Are Evaluated by a Dedicated Basal Ganglia Output"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amJuan Mena-Segovia (Rutgers University, USA)
"Cholinergic Brainstem Modulation of Striatal Circuits: Multiple Levels of Synaptic Integration"
11:15 am - 11:25 amDiscussion
11:25 am - 11:45 amMichele Basso (University of California, Los Angeles, USA)
"Cognitive Function and Dysfunction in Parkinson's Disease"
11:45 am - 11:55 amDiscussion
11:55 am - 12:10 pmTalia Lerner (Stanford University, USA)
"Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmWhat the Basal Ganglia Do: Perspectives from Computational Neuroscience
Discussion Leader: David Robbe (Institut de Neurobiologie de la Mediterranee, France)
7:30 pm - 7:50 pmMark Humphries (Manchester University, United Kingdom)
"The Computational Bottleneck of Basal Ganglia Output"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmHenry Yin (Duke University, USA)
"How the Basal Ganglia Generate Behavior"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKim Blackwell (George Mason University, USA)
"Mechanisms Underlying Dopaminergic Modulation of Striatal Dynamics and Plasticity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmEric Yttri (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Bidirectional Kinetic Control and Reinforcement in the Basal Ganglia"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPaul Dodson (University of Oxford, United Kingdom)
"Cell-Type Selective Encoding of Spontaneous Movement by Dopaminergic Neurons"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFrom Good Habits to Bad: Insights from the Dorsal and Ventral Striatum
Discussion Leader: Christian Luscher (University of Geneva, Switzerland)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amVeronica Alvarez (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Lateral Inhibition Between Striatal Projection Neurons: An Underappreciated Component of Striatal Circuit"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amChristian Luscher (University of Geneva, Switzerland)
"The Emergence of a Circuit Model for Addiction"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amXiaoke Chen (Stanford University, USA)
"An Aversive Input to the Nucleus Accumbens Is Required for Opiate Dependence"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amJohn O'Doherty (California Institute of Technology, USA)
"Neural Computations Underlying Arbitration Between Model-Based and Model-Free Reinforcement-Learning"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amJustin O'Hare (Duke University, USA)
"Pathway-Specific Striatal Substrates for Habit"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmChristoph Kellendonk (Columbia University, USA)
"Accumbens Core D2 Receptors Regulate Motivation by Inhibiting Indirect Pathway and Disinhibiting Direct Pathway and Disinhibiting Direct Pathway Output"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBasal Ganglia Dysfunction in Neurodegenerative Disease: New Insights and Opportunities
Discussion Leader: William Dauer (University of Michigan Medical School, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmX. William Yang (University of California, Los Angeles, USA)
"Mouse Genetic Approaches to Dissect Huntington's Disease Pathogenesis"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAlexandra Nelson (University of California, San Francisco, USA)
"Aberrant Striatal Plasticity in Mouse Models of Dyskinesia"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmHuaibin Cai (National Institute on Aging, NIH, USA)
"A Nigrostriatal Microcircuit Preferentially Affected in Parkinson's Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLynn Raymond (University of British Columbia, Canada)
"Altered Endocannabinoid-Mediated Excitatory Synaptic Plasticity in the Striatum in a Huntington's Disease Mouse Model"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAryn Gittis (Carnegie Mellon University, USA)
"Cell-Specific Pallidal Stimulation Produces Long-Lasting Recovery of Movement in a Mouse Model of Parkinson's Disease"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular and Molecular Diversity of the Basal Ganglia: Technical Innovations and Functional Insights
Discussion Leader: Bernardo Sabatini (Harvard Medical School / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 amJens Hjerling Leffler (Karolinska Institutet, Sweden)
"Single-Cell RNA Sequencing Reveals Striatal Neuronal Populations"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSavio Chan (Northwestern University, USA)
"Pallidostriatal Neurons in Parkinson's Disease"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amAmi Citri (The Hebrew University, Israel)
"A Transcriptional Code for Experience-Dependent Plasticity"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amAnne Schaefer (Mount Sinai School of Medicine, Friedman Brain Institute, USA)
"Molecular Profiling and Cellular Diversity in the Basal Ganglia"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amTibor Koos (Rutgers University, USA)
"Diversity Among Striatal Interneurons"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amKarina Abrahao (National Institutes of Health, USA)
"Identification of Specific Ethanol-Sensitive Neurons in the External Globus Pallidus"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmEileen McIver (Northwestern University, USA)
"Cellular Plasticity in the Parkinsonian Subthalamic Nucleus"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmBasal Ganglia and Action
Discussion Leader: Rui Costa (Champalimaud Foundation, Portugal)
7:30 pm - 7:40 pmIntroduction by Discussion Leader: To Go or Not To Go: Is It Really That Simple?
7:40 pm - 8:00 pmJoshua Berke (University of Michigan, USA)
"Dopamine and the Value of Work"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmMichael Frank (Brown University, USA)
"Basal Ganglia Dynamics During Active Learning and Choice"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAnatol Kreitzer (Gladstone Institutes, University of California, San Francisco, USA)
"Function of Basal Ganglia Circuits in Movement and Action Selection"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmClaire Geddes (The Salk Institute, USA)
"The Role of Striatum in Sequence Execution"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynaptic Plasticity: Mechanisms and Behavioral Consequences
Discussion Leader: Robert Malenka (Stanford School of Medicine, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader: Consensus and Controversy - Missing Pieces to Our Understanding of Synaptic Plasticity in Basal Ganglia Circuits
9:15 am - 9:35 amDavid Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Presynaptic Activation and Plasticity in Specific Corticostriatal Projections Measured In Vivo During Learning and Refinement of Actions"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amRaffaella Tonini (Istituto Italiano di Tecnologia (IIT), Italy)
"Integrated Neuromodulation at Glutamatergic Striatal Synapses"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amJones Parker (Stanford University, USA)
"Direct and Indirect Striatal Pathway Ensemble Dynamics Diverge in the Parkinsonian State"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amHaruo Kasai (Graduate School of Medicine, University of Tokyo, Japan)
"Structural Plasticity of Dendritic Spines in NAc for Reinforcement Learning"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPatrick Rothwell (University of Minnesota, USA)
"Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTim Fieblinger (Lund University, Basal Ganglia Pathophysiology Unit, Sweden)
"Cellular Alterations of Striatal Indirect Pathway Neurons Correlating with Motor Symptoms in Two Mouse Models of Huntington's Disease"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSignal Transduction in Basal Ganglia
Discussion Leader: Rosario Moratalla (Instituto Cajal, Spanish Research Council, Spain)
7:30 pm - 7:50 pmMarc Caron (Duke University Medical Center, USA)
"Implication for GPCR Functional Selectivity/Biased Signaling in the Actions of Dopamine"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMiriam Heiman (Broad Institute / Picower Institute, USA)
"Cell Type-Specific Profiling and Genetic Screening Studies of Huntington's Disease"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJean Antoine Girault (École des Neurosciences Paris Île de France, France)
"Signaling from Dendrites to Nuclei in D1 and D2 Striatal Neurons"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmVaroth Lilascharoen (University of California, San Diego, USA)
"Cell-Type and Projection-Specific Study of the External Segment of the Globus Pallidus Circuit Organization"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMary Kay Lobo (University of Maryland School of Medicine, USA)
"Imbalanced Ventral Striatal Mitochondrial Dynamics in Addiction"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS096763. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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