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Centromere Biology
Gordon Research Conference

Structural and Functional Dynamics of the Centromere in Mitosis and Meiosis

Dates

July 24-29, 2016

Location

Mount Snow
West Dover, VT

Organizers

Chair:
Beth A. Sullivan

Vice Chair:
Aaron F. Straight

Meeting Description

The centromere is the chromosomal locus where the kinetochore is assembled and spindle attachment and movement occurs during cell division. Understanding centromere structure and organization will deepen our knowledge of basic principles of cell division, Mendelian inheritance, and speciation. Defining the molecular aspects of centromere function is relevant for treating and preventing human birth defects and disease.

The GRC in Centromere Biology welcomes participants from across the globe, working in both classical genetic model organisms and non-traditional experimental systems. The inaugural 2014 Centromere Biology GRC, held at Bentley University (Waltham, MA), was met with enthusiasm as an event where centromere biologists could share their research progress and trainees could interact meaningfully with established investigators.

The 2016 Centromere Biology GRC will include experts presenting cutting-edge advances in cell imaging, structural biology, genetics, biochemistry, genomics, and chromatin biology focused on a common interest in centromere organization and dynamics. The Centromere Biology GRC aims to bring together those working in several highly relevant areas in the centromere field, some of which are often under-represented at other chromosome and centromere meetings. Such topics include, but are not limited to: genomics, comparative analyses, synthetic biology, and biophysics. The meeting is intended to create a welcoming, inclusive atmosphere for junior scientists and trainees to present their work and exchange ideas through poster sessions and informal discussions. Short talks in each session will include those chosen from poster abstracts.

The 2016 conference will emphasize studies on centromere structure and dynamics, centromeric chromatin organization, and biophysical properties of centromeres. The collegial atmosphere of this Conference, combined with session discussions, informal gatherings in afternoons and evenings, and events to promote interactions between trainees and established investigator, will provide an opportunity for scientists to build collaborations and unite areas of expertise to push the field forward in new, innovative directions.

Related Meeting

This GRC was held in conjunction with the "Centromere Biology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Centromere Basics: Composition and Function
Discussion Leader: Rachel O'Neill (University of Connecticut, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:20 pmSue Biggins (Fred Hutchinson Cancer Research Center / Howard Hughes Medical Institute, USA)
"Reconstituting Kinetochore Functions In Vitro"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:05 pmGary Karpen (Lawrence Berkeley National Laboratory, USA)
"Close Encounters with the Dark Side: Centromeres and Cancer"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBiophysical and Structural Properties of Centromeres
Discussion Leader: Daniel Foltz (Northwestern University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amKerry Bloom (University of North Carolina at Chapel Hill, USA)
"Biophysical Basis of Centromere Function"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amYamini Dalal (National Cancer Institute, NIH, USA)
"Dyad-Proximal Modifications in the CENP-A Nucleosome Influence Centromere Dynamics In Vivo"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amSelected from Poster Abstracts: Cara Vaughan (Institute of Structural and Molecular Biology, United Kingdom)
"Crystal Structure of the Sgt1-Skp1 Complex: Recruiting Hsp90 to CBF3 of the Yeast Kinetochore"
10:40 am - 10:45 amDiscussion
10:45 am - 11:05 amDon Cleveland (Ludwig Institute for Cancer Research, USA)
"Centromere Maintenance Through DNA Replication-Dependent Error Correction of CENP-A Deposition"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Konstanty Cieslinski (European Molecular Biology Laboratory, Germany)
"Structural Studies of the Budding Yeast Kinetochore Using Dual-Color Super-Resolution Microscopy"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amCharles Asbury (University of Washington, USA)
"Using Single Molecule Biophysics to Uncover How Chromosomes Are Segregated"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Rachel O'Neill (University of Connecticut, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMeiotic Specialization of Centromeres
Discussion Leader: Michael Lampson (University of Pennsylvania, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmScott Hawley (Stowers Institute for Medical Research, USA)
"The Structure of the Pericentromeric Synaptonemal Complex"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmSelected from Poster Abstracts: Elaine Dunleavy (National University of Ireland Galway, Ireland)
"Novel Roles for ATP Synthase at Centromeres in Drosophila Male Meiosis"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmJulie Cooper (National Cancer Institute, NIH, USA)
"Centromeres Impersonate Telomeres in Controlling the Initiation of Mitotic Spindle Assembly"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmArshad Desai (University of California, San Diego, USA)
"A Mechanism for Kinetochore-Microtubule Attachment Stabilization at Metaphase"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCentromeres: Drivers and Shapers of Genomes
Discussion Leader: Kerry Bloom (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMichael Lampson (University of Pennsylvania, USA)
"Violation of Mendel's First Law: Cell Biological Mechanisms of Meiotic Drive"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amHarmit Malik (Fred Hutchinson Cancer Research Center, USA)
"Causes and Consequences of Genetic Innovation in Centromeric Histones: A Drosophila Perspective"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:45 amSelected from Poster Abstracts: Paul Maddox (University of North Carolina at Chapel Hill, USA)
"Centromeric Chromatin Imparts Structural Rigidity Required to Regulate Holocentric Chromosome Length"
10:45 am - 10:55 amDiscussion
10:55 am - 11:15 amKelly Dawe (University of Georgia, USA)
"The Kindr Complex, a Novel Kinesin Family, Causes Ectopic Centromere Activity and Meiotic Drive in Maize"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amSelected from Poster Abstracts: Ines Drinnenberg (UMR 3664, Institut Curie, France)
"Overcoming AbCENS: Recurrent Loss of CenH3 in Holocentric Insects"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmBarbara Mellone (University of Connecticut, USA)
"Epigenetic Specification of Rapidly Evolving Centromeres"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenomics and Sequence-Dependent Centromere Function
Discussion Leader: Munira Basrai (National Cancer Institute, NIH, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmKaren Miga (University of California, Santa Cruz, USA)
"CENcode: Genetic and Epigenetic Annotation of Human Centromeres"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmMichael Freitag (Oregon State University, USA)
"Comparative Biology of Centromeric DNA and Kinetochores of Filamentous Fungi"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Qianhua Dong (New York University, USA)
"Position Effects in the Peri-Centromeric Repeats May Contribute to CENP-A Positioning"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmSteven Henikoff (Fred Hutchinson Cancer Research Center, USA)
"Insights into Sequence Organization and Evolution of Satellite DNA from Single-Molecule Sequencing"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCentromere and Kinetochore Dynamics
Discussion Leader: Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amPatrick Heun (University of Edinburgh, United Kingdom)
"Dissecting the Epigenetic Inheritance of the Centromere-Specific Histone CENP-A"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amSelected from Poster Abstracts: Gulsah Pekgoz Altunkaya (Research Institute of Molecular Pathology, Austria)
"CCAN Assembly Configures Composite Binding Interfaces to Promote Crosslinking of NDC80 Complexes at the Kinetochore"
9:45 am - 9:55 amDiscussion
9:55 am - 10:25 amCoffee Break
10:25 am - 10:45 amAjit Joglekar (University of Michigan, USA)
"eSAC: An Ectopic and Titratable Spindle Assembly Checkpoint"
10:45 am - 10:55 amDiscussion
10:55 am - 11:05 amSelected from Poster Abstracts: Natascha Kunzel (Heinrich-Heine-Universität Düsseldorf, Germany)
"A Novel Regulator of the Kinetochore-Microtubule Interface: Inositol Pyrophosphates"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amTatsuo Fukagawa (Osaka University, Japan)
"Epigenetic Regulation of Centromere Specification and Kinetochore Assembly"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amEdward Hinchcliffe (Hormel Institute, University of Minnesota, USA)
"Monitoring and Suppressing Aneuploidy via Histone H3.3 Phosphorylation"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Hironori Funabiki (Rockefeller University, USA)
"Dissecting the Molecular Function of a Novel Chromatin Factor CDCA7 Linked to Immunodeficiency-Centromeric Instability-Facial Anomalies (ICF) Syndrome"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCentromere Epigenetics
Discussion Leader: Steven Friedman (Oregon State University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmJiming Jiang (University of Wisconsin-Madison, USA)
"Recurrent Activation of a Latent Centromere in Maize"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmWilliam Earnshaw (University of Edinburgh, United Kingdom)
"From Cold White Hands to PREditOR and Synthetic Epigenetics"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Daniele Fachinetti (Institut Curie, France)
"CENP-B-Dependent Stabilization of Kinetochore Nucleation Makes CENP-A Dispensible for Maintaining Centromere Function"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmJames Birchler (University of Missouri, USA)
"Centromere Inactivation and De Novo Formation in Maize"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-Coding Elements Involved in Centromere Function
Discussion Leader: Shannon McNulty (Duke University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amRachel O'Neill (University of Connecticut, USA)
"Retroelements and Noncoding RNAs Linked to Centromere Turnover During Species Evolution"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amSelected from Poster Abstracts: Whitney Johnson (Stanford University, USA)
"RNA-Dependent Heterochromatin Regulation in Human Cells"
9:45 am - 9:55 amDiscussion
9:55 am - 10:30 amCoffee Break
10:30 am - 10:50 amSylvia Erhardt (ZMBH, Universität Heidelberg, Germany)
"Epigenetic Regulation of Centromeres by Non-Coding RNAs"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Yan Yu Charmaine Wong (The University of Hong Kong, Hong Kong SAR China)
"Determining the Mechanism of CSR-1 RNAi Pathway in Organizing Holocentromere in Caenorhabditis elegans"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amRobin Allshire (Wellcome Trust Centre for Cell Biology, United Kingdom)
"Dynamics of Centromeric Chromatin Domains"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmSelected from Poster Abstracts: Michael Blower (Massachusetts General Hospital, USA)
"Centromeric Transcription Regulates Aurora-B Localization and Activation"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Nick Gilbert (MRC Human Genetics Unit, United Kingdom)
"Centromeres Have a Disrupted Chromatin Structure, Generated by Transcription"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmControl of Centromeric Chromatin
Discussion Leader: Arshad Desai (University of California, San Diego, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmDaniel Foltz (Northwestern University, USA)
"Methylation of CENP-A Is an Essential Feature of the CENP-A Amino Terminus"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmSelected from Poster Abstracts: Ana Stankovic (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciência, Portugal)
"A Dual Inhibitory Mechanism Restricts Centromeric Chromatin Assembly to G1 Phase"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmMunira Basrai (National Cancer Institute, NIH, USA)
"Molecular Mechanisms Regulating Localization and Proteolysis of Centromeric Histone H3 Variant for Genome Stability"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmBen Black (University of Pennsylvania, USA)
"Centromeric Chromatin Is Built to Last"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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