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Mammalian Reproduction
Gordon Research Conference

Regulatory Processes Modulating Mammalian Reproduction

Dates

August 21-26, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Anne Croy & Amander T. Clark

Vice Chairs:
Humphrey H. Yao & Jon Oatley

Meeting Description

We are pleased to announce an informal session to be held on August 24th from 1:30 pm - 3:30 pm titled, "How Can We Contribute to Understanding Zika Virus's Challenges to Human Reproductive Health".

The 2016 Gordon Research Conference on Mammalian Reproduction will be held August 21-26 at Waterville Valley, NH. This conference will address advances in the basic biology of reproductive tract organs, placenta and mammalian germline cells. It will also feature presentations describing the impacts of environmental modulations on reproductive health and on long term health of offspring. The program will be focused on the latest advances in genetics, epigenetics and stem cells, as well as the use of genome editing tools to address the most critical scientific questions in the reproductive system.

The 2016 Gordon Research Conference on Mammalian Reproduction seeks to highlight recent advances in this multidisciplinary field and to also emphasize the translational potential of this work to human and animal health. The conference will reflect the diversity of junior and senior researchers who contribute to the reproductive sciences and medicine. Emphasis will be placed on communicating major recent conceptual and experimental advances in order to spotlight exciting new avenues of investigation. The meeting will be centered upon unpublished data and stimulating, active discussions amongst participants at all levels. We look forward to the inclusion of approximately 12 short talks of 15 minutes each that will be selected from applicants' abstracts. Poster sessions will be held each of the four full conference days. Graduate students and postdoctoral scientists are encouraged to apply.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEnvironmental Impacts upon Reproduction and Offspring Health
Discussion Leader: Amander Clark (University of California, Los Angeles, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:15 pmPatricia Hunt (Washington State University, USA)
"The Perils of Making Gametes in the 21st Century"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmJodi Flaws (University of Illinois, USA)
"Environmental Chemicals and the Female Reproductive System"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDouglas Kwon (Massachusetts Institute of Technology / Harvard University, USA)
"The Role of Genital Inflammation and the Vaginal Microbiome in HIV Acquisition Risk"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Regulation of Reproductive Outcomes
Discussion Leader: Margaret (Peggy) Petroff (Michigan State University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amKjersti Aagaard (Baylor College of Medicine, USA)
"Unexpected Beginnings: How the Intrauterine and Maternal Microbial and Metabolic Environments Influence Offspring Health"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amAlex Bortvin (Carnegie Institution for Science, USA)
"Sex-Specific Strategies and Outcomes of Transposon Control in Germ Cells"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amWenfeng An (South Dakota State University, USA)
"The Missing Link Between Retrotransposon Activation and Meiotic Failure in piRNA-Deficient Mice"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amGroup Photo / Coffee Break
11:05 am - 11:15 amKathryn Grive (Cornell University, USA)
"TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis and Primordial Follicle Development"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amHieu Nguyen (University of Hawaii at Manoa, USA)
"A New Found Function of the DNA Licensing Protein ORC4 on Polar Body Extrusion"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmMonika Ward (University of Hawaii, USA)
"To Be or Not to Be: Essential and Not So Essential Roles of Mouse Y Chromosome Genes in Germline Regulation"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSylvia Hewitt (National Institute of Environmental Health Sciences, NIH, USA)
"Negative Elongation Factor Subunit B (NELF-B) Is Essential for Endometrial Function"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Margaret (Peggy) Petroff (Michigan State University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEditing the Genes of Gametes and Embryos
Discussion Leader: Francesco Demayo (National Institute of Environmental Health Sciences, NIH, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmJohn Schimenti (Cornell University, USA)
"Genetic Variation and Human Fertility"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmF. Kent Hamra (Universtity of Texas Southwestern Medical Center, USA)
"Integrating Genome Editing Technologies into Robust Rattus norvegicus Spermatogenesis Colony Forming Assays"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmRandall Prather (University of Missouri-Columbia, USA)
"Editing the Pig Genome for Agriculture and Biomedicine"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetic Regulation in Reproduction
Discussion Leader: John McCarrey (University of Texas at San Antonio, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amMarisa Bartolomei (University of Pennsylvannia, USA)
"Regulation of Genomic Imprinting in Development and Disease"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMyriam Hemberger (Babraham Institute, United Kingdom)
"Epigenetic and Transcriptional Networks Controlling Trophoblast Stem Cells – The Stepping Stone for Normal Placentation and Reproductive Health"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amFelipe Vilella (Fundación IVI / INCLIVA, Spain)
"Maternal Endometrial Hsa-miR-30d Is Necessary for Embryo Implantation"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:15 amSteen Ooi (University College London, United Kingdom)
"A Novel Role for Microprocessor Component Drosha in Cytosine Methylation"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amQi Chen (University of Nevada, Reno School of Medicine, USA)
"Sperm tsRNAs and RNA Modifications in Diet-Induced Epigenetic Inheritance"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmSue Hammoud (University of Michigan Medical School, USA)
"Chromatin Dynamics and Its Role in Developing Germ Cells"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmChristopher Payne (Feinberg School of Medicine, Northwestern University, USA)
"Dicer1-Mediated Silencing of INSM1 in Spermatogonia Permits the Expression of PHD Finger Protein 1 and Global Polycomb Group Methyltransferase Activity"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cells in Reproduction
Discussion Leader: Wei Yan (University of Nevada School of Medicine, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmJan Brosens (University of Warwick, United Kingdom)
"Endometrial Stem Cell Deficiency and Recurrent Pregnancy Loss"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmBrian Hermann (University of Texas at San Antonio, USA)
"Defining the Mammalian Spermatogonial Stem Cell Pool"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmHarry Leitch (MRC Clinical Sciences Centre, Medical Research Council, United Kingdom)
"Nanog, Pluripotency and the Germline Revisited"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBioengineering and Reproductive Health
Discussion Leader: Kyle Orwig (University of Pittsburgh, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amDaniela Ulrich (Medical University of Graz, Austria)
"Bioengineering of the Lower Female Reproductive Tract - New Approaches for Treating Pelvic Organ Prolapse"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMats Hellstrom (University of Gothenburg, Sweden)
"Uterus Transplantation Followed by Bioengineering of the Uterus"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amYasushi Hirota (The University of Tokyo, Japan)
"STAT3 Promotes Uterine Regeneration in a Mouse Model of Decellularized Uterine Matrix Transplantation"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:15 amChris Geyer (East Carolina University, USA)
"Retinoid Catabolism Regulates Spermatogonial Fate in the Mouse Testis"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amEnrique Sosa (University of California, Los Angeles, USA)
"Developing a Non-Human Primate Model for Stem Cell and Germline Research"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmJoanna Burdette (University of Illinois at Chicago, USA)
"Engineering the Female Reproductive Tract Using Microfluidics"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmRipla Arora (University of California, San Francisco, USA)
"Imaging the Implanting Embryo and the Uterine Environment in Three-Dimensions"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmReproductive Transcription and Signaling Pathways
Discussion Leader: Diana Laird (University of California, San Francisco, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmBlanche Capel (Duke University, USA)
"Committing to Testis or Ovary Fate"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmShuangbo Kong (State Key Laboratory of Stem Cell and Reproductive Biology, China)
"Molecular Determinants of Uterine Receptivity"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmAleksandar Rajkovic (University of Pittsburgh, USA)
"Reproductive Aging and Overall Health: Is There a Link?"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmContinuing Challenges to Human Reproductive Health
Discussion Leader: Xiujun Fan (Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amJacquetta Trasler (McGill University, Canada)
"Epigenetic Targets of Environmental and Drug Exposures in Germ Cells and Embryos"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMichal Neeman (Weizmann Institute of Science, Israel)
"Recent Developments in MRI Analysis of Maternal Angiogenesis During Early Pregnancy in Mice"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amErnesto Figueiro-Filho (Federal University of Mato Grosso do Sul, Brazil)
"White Matter Diffusion Tensor Imaging (DTI) and Resting State Functional Connectivity (rs-fMRI) Differ in Children Born from Preeclamptic Gestations"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:15 amMelissa Pepling (Syracuse University, USA)
"Oocyte Survival and Follicle Formation in an Estrogen Deficient Environment"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amNava Dekel (Weizmann Institute of Science, Israel)
"Hyaluronic Acid: Anti-Angiogenic Shield for the Post-Implantation Embryo"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmAndrew Sharkey (University of Cambridge, United Kingdom)
"HLA-KIR Associations in Human Reproductive Success"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmGunter Wagner (Yale University, USA)
"The Role of Inflammation in the Evolution of Mammalian Pregnancy"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Milestones in Reproductive Biology
Discussion Leaders: Jon Oatley (Washington State University, USA) and Humphrey Yao (National Institute of Environmental Health Sciences, NIH, USA)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 6:10 pmMitch Eddy (National Institute of Environmental Health Sciences, NIH, USA)
"The Ark of Life: The Germ Line - Past, Present and Future"
6:10 pm - 6:25 pmDiscussion
6:25 pm - 6:35 pmIntroduction by Discussion Leader
6:35 pm - 7:05 pmMarilyn Renfree (University of Melbourne, Australia)
"Reproduction Down Under: The 6% Solution"
7:05 pm - 7:20 pmDiscussion
7:20 pm - 7:25 pmGeneral Discussion
7:25 pm - 7:30 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number R13HD089561. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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