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Rare Cells in Circulation
Gordon Research Conference

Circulating Tumor Cells and Other Tumor Products in the Circulation
Note: This conference is currently known as "Liquid Biopsy for Cancer".

Dates

August 7-12, 2016

Location

Mount Holyoke College
South Hadley, MA

Organizers

Chairs:
Andrew D. Rhim & Howard I. Scher

Vice Chairs:
Shannon Stott & Stefanie Jeffrey

Meeting Description

The past decade has seen significant advancements in technologies that allow for the capture and analysis of tumor products (e.g., cells, microvesicles, DNA) from the peripheral circulation. In this year's GRC, we will focus on the next steps for application of these technologies to the clinic. We will provide an overview of the field, with free and timely discussions of various aspects of the analysis of circulating tumor cells, cell free DNA and exosomes and microvesicles, and their comparative strengths and weaknesses. We will also discuss best practices and requirements for new technologies to be successfully implemented as a clinical test, highlighting several successes at varying stages of development. Finally, this GRC will provide a forum for researchers young and seasoned to present cutting-edge work and foster interdisciplinary collaboration.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Foundations: Dissemination, Metastasis, and Evolution
Discussion Leader: Brian Kirby (Cornell University, USA)
7:40 pm - 8:25 pmPeter Kuhn (University of Southern California, USA)
"Current State of Liquid Biopsies: Challenges and Triumphs"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmKlaus Pantel (University Medical Center Hamburg-Eppendorf, Germany)
"Circulating Tumor Cells: Detection, Biology, and Clinical Implications"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCirculating Tumor Cells: New Technologies and Applications
Discussion Leader: Erica Pratt (University of Texas MD Anderson Cancer Center / University of Michigan, USA)
9:00 am - 9:40 amStefanie Jeffrey (Stanford University, USA)
"Novel Technologies for the Capture and Analysis of CTCs"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amShana Kelley (University of Toronto, Canada)
"New Technologies for Phenotypic Profiling of Circulating Tumor Cells"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:50 amHoward Scher (Memorial Sloan Kettering Cancer Center, USA)
"Prostate Cancer Biomarker Development: Validation and Utility Are All That Really Matter"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmYoon-Kyoung Cho (Ulsan National Institute of Science and Technology, South Korea)
"Robust and Ultrasensitive Point-of-Care Detection of Circulating Tumor Cells on a Spinning Disc"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSam Au (Harvard Medical School, USA)
"Threading the Needle: Can Cancer Cell Clusters Travel Through Capillary-Sized Blood Vessels"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntellectual Property, Regulatory Approval, and Statistical Considerations
Discussion Leader: Peter Kuhn (University of Southern California, USA)
7:30 pm - 8:05 pmW. Nicholson Price (University of Michigan Law School, USA)
"Intellectual Property for Diagnostics: Prometheus, Myriad, Alice and Ariosa"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmElizabeth Mansfield (U.S. Food and Drug Administration, USA)
"Molecular Assays and Diagnostics for Cancer: A Regulatory Perspective"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmMartin Fleisher (Memorial Sloan Kettering Cancer Center, USA)
"Validating Assays for Use in the Clinic"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmClinical Testing and Applications: Considerations for Implementation
Discussion Leader: Klaus Pantel (University Medical Center Hamburg-Eppendorf, Germany)
9:00 am - 9:45 amMark Lee (GRAIL, Inc., USA)
"Circulating Cell-Free Nucleic Acids and Early Cancer Detection"
9:45 am - 9:55 amDiscussion
9:55 am - 10:40 amRobert McCormack (Johnson & Johnson, USA)
"Liquid Biopsy and Personalized Medicine in an Era of Evidence-Based Medicine: The CellSearch® CTC Experiment"
10:40 am - 10:50 amDiscussion
10:50 am - 11:15 amCoffee Break
11:15 am - 12:00 pmRyan Dittamore (Epic Sciences, USA)
"Promise, Pitfalls, and Premise for Developing Cancer Biomarkers"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCirculating Tumor Cells: Characterization
Discussion Leader: Andrew Rhim (University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 8:10 pmDaniel Haber (Massachusetts General Hospital, USA)
"Understanding Cancer Progression Through Analysis of Circulating Tumor Cells"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmBrian Kirby (Cornell University, USA)
"Manipulating Rare Cells and Vesicles in Microfluidic Devices: Interrogating Drug Resistance and Surgical Risk Staging"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmDannielle Engle (Cold Spring Harbor Laboratory, USA)
"Accelerating Biomarker and Therapeutic Discovery with Organoid Models of Pancreatic Cancer"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCirculating Tumor DNA: Utility and Advanced Methods
Discussion Leader: Tony Godfrey (Boston University, USA)
9:00 am - 9:40 amNicholas Turner (Institute for Cancer Research, United Kingdom)
"Predicting Relapse Using Circulating Tumor DNA in Breast Cancer"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amViktor Adalsteinsson (Broad Institute of MIT and Harvard, USA)
"Whole-Exome Sequencing of Liquid Biopsies"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:50 amMaximilian Diehn (Stanford University, USA)
"Deep Sequencing of Circulating Tumor DNA for Personalized Cancer Detection and Monitoring"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMatthew Egyud (Boston Medical Center, USA)
"Detection of Tumor-Specific Mutations in Circulating, Cell-Free DNA: Potential for a Biomarker in Esophageal Adenocarcinoma"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmYaping Liu (Massachusetts Institute of Technology, USA)
"Identifying Cell Free DNA's Tissues-of-Origin in Cancer by Whole Genome Sequencing"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmExosomes and Microvesicles in Cancer
Discussion Leader: Shannon Stott (Massachusetts General Hospital, USA)
7:30 pm - 8:00 pmXandra Breakefield (Harvard University / Massachusetts General Hospital, USA)
"The Language of Extracellular Vesicles"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDolores Di Vizio (Cedars-Sinai Medical Center, USA)
"Heterogeneity of Cancer-Derived Extracellular Vesicles"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmRaghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"The Biology and Function of Exosomes in Diagnosis and Treatment of Cancer"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmClinical Applications: Guiding Treatment
Discussion Leader: Amir Goldkorn (University of Southern California, USA)
9:00 am - 9:40 amAnirban Maitra (University of Texas MD Anderson Cancer Center, USA)
"Liquid Biopsies for Therapeutic Stratification and Disease Monitoring in Pancreatic Cancer"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amAndy Minn (University of Pennsylvania, USA)
"Exosomes from the Tumor Microenvironment Promote Cancer Progression Through Viral Mimicry"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:50 amMichael Speicher (Medical University of Graz, Austria)
"Liquid Biopsies to Characterize Breast Cancer in Real Time"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmFredrik Thege (Cornell University, USA)
"Elucidating the Effect of EMT and Chemoresistance on Pancreatic CTC Capture and Vesicle Shedding"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmEduardo Reategui (Massachusetts General Hospital, USA)
"Characterization of Tumor-Specific Extracellular Vesicles from Glioblastoma Patients Using Microfluidic Technologies"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmClinical Applications: Response and Relapse
Discussion Leader: Stefanie Jeffrey (Stanford University, USA)
7:30 pm - 8:00 pmJeanne Tie (Walter and Eliza Hall Institute of Medical Research, Australia)
"Circulating Tumor DNA in Colorectal Cancer: Assessing Minimal Residual Disease and Treatment Response"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmAmir Goldkorn (University of Southern California, USA)
"Using CTCs to Assess Treatment Response and Prognosis in Prostate Cancer"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmShannon Stott (Massachusetts General Hospital, USA)
"Microfluidics for the Interrogation of Biomarkers in Glioblastoma Patients"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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