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Genomic Instability
Gordon Research Conference

DNA Packaging, Replication, and Repair

Dates

July 24-29, 2016

Location

The Hong Kong University of Science and Technology
Hong Kong, China

Organizers

Chairs:
Robert S. Weiss & Junjie Chen

Vice Chairs:
Anja Groth & Anindya Dutta

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Meeting Description

The Gordon Research Conference (GRC) on Genomic Instability is designed to address diverse research areas focused on genomic instability caused by faulty DNA transactions that occur spontaneously or under stress conditions. Cells continuously experience genome damage that, if not properly corrected, can have a variety of negative consequences, ranging from cell death to uncontrolled oncogenic proliferation. Inherited defects in genome protection mechanisms are responsible for a variety of human diseases, such as Ataxia Telangiectasia, Fanconi Anemia, and Cockayne syndrome, most of which are associated with developmental defects, premature aging, and dramatically increased cancer risk. This GRC provides broad coverage of the entire field of Genomic Instability and integrates basic and applied elements. Each session will include both invited speakers and speakers selected from submitted abstracts. Cutting edge research will be presented on the molecular mechanisms involved in the repair and processing of abnormal DNA structures, signaling pathways for DNA damage responses, and the physiological consequences of errors introduced by these processes. Additional topics to be covered include replication fork challenges, the impact of chromosome condensation and segregation on genomic integrity, chromatin structure and epigenetic regulation in genome maintenance, and DNA repair pathways as therapeutic targets. The Genomic Instability GRC will be preceded by a Gordon Research Seminar for trainees on July 23-24, 2016.

Related Meeting

This GRC was held in conjunction with the "Genomic Instability" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTelomere Replication and Integrity
Discussion Leader: Lee Zou (Massachusetts General Hospital / Harvard Medical School, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:10 pmRoger Greenberg (University of Pennsylvania, USA)
"Mechanisms of ALT Telomere Recombination"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmJan Karlseder (The Salk Institute, USA)
"What Telomeres Can Teach Us About DNA Repair Pathway Choice"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmRoger Reddel (Children's Medical Research Institute, Australia)
"Role of Shelterin in Signaling Telomere-Induced Growth Arrest"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Cohesion, Condensation, and Segregation
Discussion Leader: Kyungjae Myung (Institute for Basic Science (IBS), South Korea)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amLars Jansen (Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian, Portugal)
"Histone Variant Inheritance and Assembly at the Centromere and Beyond"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amHuilin Zhou (University of California, San Diego, USA)
"Chromosome Translocations, SUMO and the DNA Replisome"
9:55 am - 10:05 amDiscussion
10:05 am - 10:20 amSelected from Poster Abstracts: Jessica Woodward (University of Edinburgh, United Kingdom)
"The Requirement for Condensin II During Mitosis Correlates with S Phase Kinetics During Lymphocyte Development"
10:20 am - 10:25 amDiscussion
10:25 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:10 amYoshinori Watanabe (University of Tokyo, Japan)
"Regulation and Function of the Kinetochore Protein Shugoshin"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amXuebiao Yao (University of Science and Technology of China, China)
"Molecular Delineation of CDK1-TIP60-Aurora B Signaling Axis in Chromosome Segregation"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmKaren Wing Yee Yuen (The University of Hong Kong, Hong Kong SAR China)
"Epigenetic Regulation of Centromere Propagation and Establishment"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Hong Wang (North Carolina State University, USA)
"Cohesin SA1 and SA2 Recognize Specific DNA Sequences and Structures: A Tale of Two Proteins"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Bik Tye (Hong Kong University of Science and Technology, Hong Kong SAR China)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDSB Repair and Recombination
Discussion Leader: Tanya Paull (University of Texas at Austin, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmPatrick Sung (Yale University, USA)
"Mechanism for Synaptic Complex Assembly in Homologous Repair"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmK. Muniyappa (Indian Insitute of Science, India)
"A Novel Holliday Junction Resolvase from Mycobacterium tuberculosis"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmGaelle Legube (University of Toulouse, France)
"Chromatin and Chromosome Dynamics During DNA Double Strand Break Repair"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmSelected from Poster Abstracts: Hilda Pickett (Children's Medical Reserach Institute, Australia)
"Recombination-Directed Replication in Alternative Lengthening of Telomeres"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReplication Fork Challenges: Coiling, Collapse and Coalition
Discussion Leader: Patrick Sung (Yale University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amAnindya Dutta (University of Virginia, USA)
"MCM8-9 and ORC in Maintenance of Genome Stability"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amZhiguo Zhang (Mayo Clinic, USA)
"Impact of Histone Mutations in Cancer Epigenome"
9:55 am - 10:05 amDiscussion
10:05 am - 10:20 amSelected from Poster Abstracts: Sung-Bau Lee (Taipei Medical University, Taiwan)
"Tousled-Like Kinases Govern Chromatin Assembly and Replication Fork Stability"
10:20 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:10 amJesper Svejstrup (The Francis Crick Institute, United Kingdom)
"Transcription-Related Genome Instability"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amSelected from Poster Abstracts: Wai Chung (Justin) Leung (University of Texas at Austin, USA)
"ZMYM3/ZNF261 Promotes Homologous Recombination via BRCA1-A Complex Axis"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Chit Fang Cheok (IFOM, the FIRC Institute of Molecular Oncology, Singapore)
"p53 Maintains Genomic Stability by Preventing Replication Transcription Collisions"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmThanos Halazonetis (University of Geneva, Switzerland)
"Mechanisms of Oncogene-Induced DNA Replication Stress"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmReplication of Normal and Damaged DNA Templates
Discussion Leader: Thanos Halazonetis (University of Geneva, Switzerland)
4:00 pm - 4:05 pmIntroduction by Discussion Leader
4:05 pm - 4:25 pmBik Tye (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Structural Analysis of the Earliest Steps of DNA Replication Initiation"
4:25 pm - 4:35 pmDiscussion
4:35 pm - 4:55 pmHiroyuki Araki (National Institute of Genetics, Japan)
"Molecular Mechanisms of Eukaryotic DNA Replication"
4:55 pm - 5:05 pmDiscussion
5:05 pm - 5:25 pmDeog Su Hwang (Seoul National University, South Korea)
"Protein Phosphatase 1 Dephosphorylates Orc2 for the ORC Binding to Chromatin and Replication Origins"
5:25 pm - 5:35 pmDiscussion
5:35 pm - 5:50 pmSelected from Poster Abstracts: Yandong Yin (New York University School of Medicine, USA)
"Quantitative Imaging of the Internal Organization of Individual Replication Forks in Human Cells"
5:50 pm - 5:55 pmDiscussion
5:55 pm - 6:00 pmGeneral Discussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Dynamics and (Epi)Genome Maintenance
Discussion Leader: Roger Greenberg (University of Pennsylvania, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amAnja Groth (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)
"Chromatin Replication and Epigenome Maintenance"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amTitia Sixma (Netherlands Cancer Institute, The Netherlands)
"Controlling the Dubs in DNA Damage and Chromatin Regulation"
9:55 am - 10:05 amDiscussion
10:05 am - 10:20 amSelected from Poster Abstracts: Qing Li (Peking University, China)
"A Novel Role of RPA During DNA Replication Coupled Nucleosome Assembly"
10:20 am - 10:25 amDiscussion
10:25 am - 11:00 amCoffee Break
11:00 am - 11:15 amKui Ming Chan (City University of Hong Kong, Hong Kong SAR China)
"Replication Independent Chromatin Function of MCM3"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amSelected from Poster Abstracts: Amity Manning (Worcester Polytechnic Institute, USA)
"Drug Resistance in CIN Cancer Cells Is Sensitive to Manipulation of Cohesion"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmGuoliang Xu (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China)
"Enzymatic Oxidation of 5-Methylcytosine in Mammalian Genome"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Chengmin Qian (The University of Hong Kong, Hong Kong SAR China)
"New Mechanistic Insights into Dnmt1-Mediated Maintenance DNA Methylation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmDNA Repair in Development and Aging
Discussion Leader: Hilda Pickett (Children's Medical Reserach Institute, Australia)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmVera Gorbunova (University of Rochester, USA)
"SIRT6 Promotes More Efficient DNA Repair in Long-Lived Mammals"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmPeter McKinnon (St. Jude Children's Research Hospital, USA)
"Base Excision Repair During Development and Maintenance of the Nervous System"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:50 pmSelected from Poster Abstracts: Stuart Rulten (Genome Damage and Stability Centre, University of Sussex, United Kingdom)
"Parp, Xrcc1, Genome Stability and Disease"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmZhongjun Zhou (The University of Hong Kong, Hong Kong SAR China)
"Nuclear Lamin A in Chromatin Remodeling, DNA Damage Repair and Aging"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Damage Signaling
Discussion Leader: Titia Sixma (Netherlands Cancer Institute, The Netherlands)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amTanya Paull (University of Texas at Austin, USA)
"Processing of Protein-DNA Adducts in Eukaryotic Cells"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amMichael Huen (The University of Hong Kong, Hong Kong SAR China)
"Self-Restraining Mechanisms of Chromatin Responses at DSBs"
9:55 am - 10:05 amDiscussion
10:05 am - 10:20 amSelected from Poster Abstracts: Anindya Roy (Indian Institute of Technology Hyderabad, India)
"RecA Stimulates Alkb-Mediated Direct Repair of DNA Adducts"
10:20 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:10 amHuadong Pei (State Key Laboratory of Proteomics, China)
"Regulation of DNA Replication and Cell Cycle Progression by the Histone Methyltransferase MMSET"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amSelected from Poster Abstracts: Zhiyuan Shen (Rutgers Cancer Institute of New Jersey, USA)
"Suppression of DNA Replication Stress and Mitotic Infidelity by BCCIP Isoforms"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmLee Zou (Massachusetts General Hospital / Harvard Medical School, USA)
"New Insights into the Functions of ATR Kinase in DNA Repair"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Shunichi Takeda (Kyoto University, Japan)
"Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmDNA Repair as a Therapeutic Target
Discussion Leader: Michael Huen (The University of Hong Kong, Hong Kong SAR China)
4:00 pm - 4:05 pmIntroduction by Discussion Leader
4:05 pm - 4:25 pmEric Lightcap (Takeda Pharmaceuticals International, USA)
"Nedd8-Activating Enzyme Inhibitor Pevonedistat Synergizes with Cisplatin and Carboplatin Through Interference with Nucleotide Excision Repair and Interstrand Cross-Link Repair Mechanisms"
4:25 pm - 4:35 pmDiscussion
4:35 pm - 4:55 pmXiaochun Yu (City of Hope, USA)
"An Endogenous PARP Inhibitor"
4:55 pm - 5:05 pmDiscussion
5:05 pm - 5:20 pmSelected from Poster Abstracts: Alexander Bishop (University of Texas Health Science Center at San Antonio, USA)
"R-Loops, Recombination and Brca1 Defects in Ewing Sarcoma"
5:20 pm - 5:25 pmDiscussion
5:25 pm - 5:45 pmKyungjae Myung (Institute for Basic Science (IBS), South Korea)
"Translation of DNA Repair Mechanisms to a Potential Chemotherapeutic Agent Discovery"
5:45 pm - 5:55 pmDiscussion
5:55 pm - 6:00 pmGeneral Discussion
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Any opinions, findings, conclusions or recommendations expressed in this material/event (or by members of the project team) do not reflect the views of the Government of the Hong Kong Special Administrative Region, the Innovation and Technology Commission or the Vetting Committee of the General Support Programme of the Innovation and Technology Fund.
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