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Artificial Molecular Switches & Motors
Gordon Research Conference

Controlling Movement on the Molecular Scale

Dates

June 11-16, 2017

Location

Holderness School
Holderness, NH

Organizers

Chair:
Amar H. Flood

Vice Chairs:
Ivan Aprahamian & Stephen Goldup

Meeting Description

Across all scales, mechanical machines generate motion. That motion is characterized by the coherent change in location of one body with respect to another. Across all ages, we have been aware of the usefulness of controlling motion. With engineered motors now replacing horsepower, the modern world is filled with mechanized machines to perform work of all kinds. We also recognize that these devices perform work we either find demanding or that occurs in places in which we cannot act, such as at the nanoscale. It is on this scale, starting from molecules, that we must start to understand, design, and create the next generation of switches and motors to mechanize our world from the bottom up. Nature provides the ultimate inspiration with sliding actin-myosin fibers painting a picture of a mechanized nanotechnology where many small motors impact our macroscopic world.

This GRC acknowledges that the formative steps to switch and motorize molecular matter are being taken now. For this reason, we provide a forum for a multidisciplinary group of researchers to present ideas, experimental realizations, and physical descriptions of artificial switches and motors. Organic chemists create novel molecules performing reversible switching. Theoretical scientists provide the understanding that underpins predictive designs. Soft and hard matter scientists and engineers integrate molecular switches into higher-order architectures, ultimately giving rise to larger devices. Bioengineers and physicists create kinesin-like walkers to test understanding of small motors. Biology is also manipulated when switches are harnessed to control when and where enzymes function. All these possibilities rely on the controlling the movement of matter on molecular length scales. For this reason, the open exchange of ideas and ample time for discussion places the GRC in an ideal position to provide a forum for presenting the frontiers of Artificial Molecular Switches and Motors.

Related Meeting

This GRC was held in conjunction with the "Artificial Molecular Switches & Motors" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmHarnessing Molecular Switches and Machines
Discussion Leader: Stephen Goldup (University of Southampton, United Kingdom)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmRafal Klajn (Weizmann Institute of Science, Israel)
"Molecular Switching in Confined Spaces"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJ. Fraser Stoddart (Northwestern University, USA)
"Exploring Ways of Getting Molecular Machines to (Do) Work"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSwitches at the Interface with Biology
Discussion Leader: Stefan Hecht (Humboldt University of Berlin, Germany)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:50 amDirk Trauner (New York University, USA)
"Teaching Old Dogs New Tricks with Synthetic Photoswitches"
9:50 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:20 amAngelique Y. Louie (University of California, Davis, USA)
"Molecular Switches for Biomedical Imaging"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmMarina Kuimova (Imperial College London, United Kingdom)
"Mapping Microscopic Viscosity and Temperature Using Molecular Rotors"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSwitchable Assemblies
Discussion Leader: Oren Scherman (University of Cambridge, United Kingdom)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmXi Zhang (Tsinghua University, China)
"Cucurbituril as Building Blocks for Switchable Assemblies"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmToshikazu Takata (Tokyo Institute of Technology, Japan)
"Switchable Polyrotaxanes"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBioinspired Machines
Discussion Leader: R. Dean Astumian (University of Maine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:50 amHenry Hess (Columbia University, USA)
"Engineering with Biomolecular Motors"
9:50 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:20 amHeiner Linke (Lund University, Sweden)
"Protein Motors – Design and Applications to Parallel Computing"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmScott Cockroft (University of Edinburgh, United Kingdom)
"Transmembrane Molecular Machines"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Switches
Discussion Leader: Mindy Levine (University of Rhode Island, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmStephen J. Loeb (University of Windsor, Canada)
"Switching Interlocked Molecules in Porous Solids"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJonathan Sessler (University of Texas at Austin, USA)
"Logic Switching Without (Mechanical) Bonds"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Motions
Discussion Leader: Rainer Herges (University of Kiel, Germany)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:50 amMitsuhiko Shionoya (The University of Tokyo, Japan)
"Metal-Mediated Supramolecular Motors and Switches"
9:50 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:20 amAnne-Sophie Duwez (University of Liege, Belgium)
"Probing Single Molecules with the AFM: Force, Motion, Dynamics, and Function"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmNicolas Giuseppone (Institut Charles Sadron, University of Strasbourg, France)
"Out-of-Equilibrium Integration of Molecular Machines"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmTowards Soft Machines
Discussion Leader: Edith Sevick (The Australian National University, Australia)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:20 pmNathalie Katsonis (University of Twente, The Netherlands)
"Soft Molecular Machines: Driven by Strain and Sustained by Diffusion"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmTakuzo Aida (RIKEN Center for Emergent Matter Science (CEMS) / The University of Tokyo, Japan)
"Toward Robotic Nanocarriers"
9:15 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Switches
Discussion Leader: James Crowley (University of Otago, New Zealand)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:50 amAlexander Lippert (Southern Methodist University, USA)
"Fluorescent Photoswitch Chemistry for Volumetric 3D Displays"
9:50 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:20 amLi-Zhu Wu (Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China)
"A Redox Shuttle Enhances Chemical Transformation"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmNatia Frank (University of Victoria, Canada)
"Optically Switching Charge and Energy Transfer Processes: Molecules to Devices"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrontiers in Artificial Molecular Switches and Motors
Discussion Leader: Eric Masson (Ohio University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:45 pmFlorian Gutzeit (Christian-Albrechts-Universität zu Kiel, Germany)
"Design and Synthesis of Hair Clip Porphyrins. Developing a New Kind Photoswitch Based on Positive Intramolecular Feedback in Nickel(II)porphyrins"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmJames Cooper (Northwestern University, USA)
"Discrimination of Supramolecular Chirality Using a Protein Nanopore"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmShort Talk Selected from Poster Abstracts
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:30 pmShort Talk Selected from Poster Abstracts
8:30 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmBen L. Feringa (University of Groningen, The Netherlands)
"Molecular Motors"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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