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Membrane Protein Folding
Gordon Research Conference

Folding Biophysics, Design, and Stabilization with Applications to Disease

Dates

June 4-9, 2017

Location

Stonehill College
Easton, MA Site Information

Organizers

Chair:
James U. Bowie

Vice Chair:
Charles R. Sanders

Application Deadline

Applications for this meeting must be submitted by May 7, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

An understanding of protein folding is essential for most of the major quests of structural biology, including learning how to predict structure, how proteins evolve, how mutations cause disease and how to design novel proteins. As a result, protein folding has been a major field of investigation for the past 50 years. In this effort, however, membrane proteins have been largely ignored. In-depth folding experiments on membrane proteins have lagged behind their soluble counterparts not because membrane proteins are unimportant, but because they are simply hard to study. This conference will bring together cellular, biophysical and computational investigations of membrane protein folding and design with the purpose of sharing expertise and solutions to this challenging problem.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMembrane Integration and Removal of Helical Membrane Proteins
Discussion Leader: James Bowie (University of California, Los Angeles, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:10 pmStephen White (University of California, Irvine, USA)
"Translocon Recognition and Membrane Stability of Transmembrane Helices"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmJoachim Herberle (Freie Universitat Berlin, Germany)
"In-Situ Observation of Membrane Protein Insertion and Folding During Cell-Free Expression by SEIRAS"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmTom Rapoport (Harvard Medical School / Howard Hughes Medical Institute, USA)
"Mechanism of ER-Associated Protein Degradation (ERAD)"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBiophysics of Helical Membrane Protein Folding
Discussion Leader: Charles Deber (University of Toronto, Canada)
9:00 am - 9:25 amPaula Booth (King's College London, United Kingdom)
"Folding Alpha Helical Membrane Proteins: Thermodynamics, Lipid Bilayer Mechanics and Co-Translational Folding"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk Selected from Poster Abstracts
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amDaniel Muller (ETH Zurich, Switzerland)
"Observing the Insertase-Assisted Insertion and Folding Steps of Single Membrane Proteins"
10:15 am - 10:25 amDiscussion
10:25 am - 10:35 amShort Talk Selected from Poster Abstracts
10:35 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amThomas Perkins (JILA, University of Colorado Boulder, USA)
"Hidden Dynamics in the Unfolding of Individual Bacteriorhodopsin Proteins"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmArt Laganowski (Texas A&M University, USA)
"Probing Membrane Protein-Lipid Interactions by Native Ion Mobility Mass Spectrometry"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Karen Fleming (Johns Hopkins University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembrane Protein Structure Prediction and Design
Discussion Leader: Hang "Hubert" Yin (University of Colorado, USA)
7:30 pm - 7:55 pmJens Meiler (Vanderbilt University, USA)
"Simulating Membrane Protein Folding from Limited Experimental Data"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmSarel Fleishman (Weizmann Institute of Science, Israel)
"An Energy Function for Design and Structure Prediction in Membrane Proteins"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk Selected from Poster Abstracts
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmPeter Woylnes (Rice University, USA)
"Predictive Energy Landscapes for Folding Membrane Proteins"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane Protein Folding in Disease
Discussion Leader: Radhakrishnan Mahalakshmi (Indian Institute of Science Education and Research, Bhopal, India)
9:00 am - 9:25 amJonathan Schlebach (Indiana University, USA)
"Elucidation of Bottlenecks in the Quality Control and Cellular Trafficking of PMP22"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk Selected from Poster Abstracts
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amKalina Hristova (Johns Hopkins University, USA)
"Heterodimerization of Receptor Tyrosine Kinases in Health and Disease"
10:15 am - 10:25 amDiscussion
10:25 am - 10:35 amShort Talk Selected from Poster Abstracts
10:35 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amGergely Lukacs (McGill University, Canada)
"Structural and Proteostatic Determinants of CFTR Functional Expression at the Cell Surface"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmSabine Hadida (vertex pharmaceuticals, USA)
"Correcting CFTR Protein Processing and Trafficking to Treat the Underlying Cause of Cystic Fibrosis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembrane Protein Stabilization
Discussion Leader: Karen Fleming (Johns Hopkins University, USA)
7:30 pm - 7:55 pmPil Seok Chae (Hanyang University, South Korea)
"Novel Detergent Tools for GPCR Structural Study"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmLinda Columbus (University of Virginia, USA)
"Protein-Surfactant Interactions Do Determine Fold"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk Selected from Poster Abstracts
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmAndreas Pluckthun (University of Zurich, Switzerland)
"Stabilizing GPCRs"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBeta Barrel Folding Biophysics and Biogenesis
Discussion Leader: Linda Columbus (University of Virginia, USA)
9:00 am - 9:25 amKaren Fleming (Johns Hopkins University, USA)
"Driving Forces for Sorting and Folding of Outer Membrane Proteins"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk Selected from Poster Abstracts
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amZengyi Chang (Peking University, China)
"The Biogenesis and Quality Control of Beta Barrel Outer Membrane Proteins as Explored in Living Cells"
10:15 am - 10:25 amDiscussion
10:25 am - 10:35 amShort Talk Selected from Poster Abstracts
10:35 am - 10:40 amDiscussion
10:40 am - 11:05 amCoffee Break
11:05 am - 11:30 amRadhakrishnan Mahalakshmi (Indian Institute of Science Education and Research, Bhopal, India)
"Interface Energetics and Beta Barrel Folding"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmSheena Radford (University of Leeds, United Kingdom)
"Mechanistic Insights into Outer Membrane Protein Folding"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMembrane Protein Folding in Amyloid Disease
Discussion Leader: Charles Sanders (Vanderbilt University, USA)
7:30 pm - 7:55 pmCeline Galvagnion (University of Cambridge, United Kingdom)
"Amyloid Proteins - Membrane Interactions: The Influence of the Lipid Composition on the Kinetics of Aggregation"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmKatsumi Matsuzaki (Kyoto University, Japan)
"Mechanisms of Abnormal Aggregation and Toxicity of Alzheimer's Amyloid Beta-Protein on Neuronal Membranes"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk Selected from Poster Abstracts
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJennifer Lee (National Institutes of Health, USA)
"Membrane Interactions and Amyloid Formation of α-Synuclein"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAssembly of Membrane Protein Complexes
Discussion Leader: Paula Booth (King's College London, United Kingdom)
9:00 am - 9:25 amJebrell Glover (Lehigh University, USA)
"Biophysical and Biochemical Insights into Caveolin-1"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk Selected from Poster Abstracts
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amAdam Smith (University of Akron, USA)
"Resolving the Dimerization Interface of Visual Opsins with PIE-FCCS"
10:15 am - 10:25 amDiscussion
10:25 am - 10:45 amCoffee Break
10:45 am - 11:10 amCharles Deber (University of Toronto, Canada)
"Peptide-Based Approaches to Inhibiting Protein-Protein Interactions in Membranes"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amCharles Brooks (University of Michigan, USA)
"The Role of pH in Modulating Membrane Protein Structure and Function"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmWilliam Degrado (University of California, San Francisco, USA)
"Understanding Transmembrane Signal Transduction in Bacterial Histidine Kinases"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMembrane Protein Design for Disease Therapy
Discussion Leader: Kalina Hristova (Johns Hopkins University, USA)
7:30 pm - 7:55 pmDaniel Dimaio (Yale University, USA)
"Building Transmembrane Proteins with Minimal Chemical Complexity"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmHang "Hubert" Yin (University of Colorado, USA)
"Rational Design of Membrane Curvature Sensors"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk Selected from Poster Abstracts
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDonald Engelman (Yale University, USA)
"pHLIP®: Uses in Measuring Cell Surface pH, Imaging Tumors, and Delivering Therapeutics"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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