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Parkinson's Disease
Gordon Research Conference

Integrating Diverse Research to Address Critical Issues in Parkinson's Disease

Dates

June 25-30, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME Site Information

Organizers

Chair:
Andrew Singleton

Vice Chair:
J. Timothy Greenamyre

Application Deadline

Applications for this meeting must be submitted by May 28, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The Gordon Research Conference on Parkinson's disease is a unique meeting within the field that brings together scientists across myriad disciplines and from varied backgrounds and positions around the common theme of Parkinson's disease research. The aim of the meeting is to stimulate debate, raise questions of critical importance, exchange information, and create an atmosphere that encourages collaboration and collegiality. This meeting will focus on creating connections across disciplines, between scientists from academic, government, and pharmaceutical research groups, and researchers, from those new to the area through to the thought leaders in the field.

The field of Parkinson's disease research has matured tremendously over the last 20 years, in large part much of this progress has been driven by genetic and molecular insights into disease etiology and pathogenesis. This conference aims to bring together scientists interested in understanding the underlying disease processes with an eye toward effecting the development and deployment of etiologic based therapeutics.

Related Meeting

This GRC will be held in conjunction with the "Parkinson's Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Informing Etiology Through the Clinic
Discussion Leader: Andrew Singleton (National Institutes of Health, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:15 pmIntroduction by Discussion Leader
8:15 pm - 9:00 pmWilliam Langston (The Parkinson's Institute, USA)
"What Is Parkinson's Disease and Why Is It Important for Understanding Biology"
9:00 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmParkinson's Disease Genetics and Systems Biology
Discussion Leader: John Hardy (University College London, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amRoy Alcalay (Columbia University, USA)
"Glucocerebrosidase, Glycosphingolipids and Parkinson's Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amMichel Desjardins (Universite de Montreal, Canada)
"Autoimmune Mechanisms in Parkinson's Disease"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amSteven Finkbeiner (University of California, San Francisco, USA)
"Applications of Functional Genomics to Parkinson's Disease"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amPeter Heutink (German Center for Neurodegenerative Diseases / University of Tübingen, Germany)
"High-Content Screening and Genomic Approaches for PD"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmMatt LaVoie (Harvard University, USA)
"Neuronal and Non-Neuronal Function and Dysfunction"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Roberta Brinton (University of Southern California, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGene-Environment Interaction
Discussion Leader: Jeff Bronstein (University of California, Los Angeles, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmGary Miller (Emory University, USA)
"Advancing Parkinson's Disease Research by Using Clues from the Environment"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmJason Richardson (Northeast Ohio Medical University, USA)
"Gene-Environment Interactions in PD: Role of Efflux Transporters"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmBeate Ritz (University of California, Los Angeles, USA)
"Assessing Gene-Environment Interactions: Success Stories in Parkinson's Disease"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLRRK2: From Protein, Through Cell Biology to Therapeutic Intervention
Discussion Leader: Marco Baptista (The Michael J. Fox Foundation for Parkinson's Research, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amDario Alessi (University of Dundee, United Kingdom)
"New Assays and Pathways that Activate LRRK2"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amMatthew Kennedy (University of Colorado School of Medicine, USA)
"Challenges of Neurodegenerative Disease Drug Discovery: BACE Inhibitors for Alzheimer's Disease vs. LRRK2 Inhibitors for Parkinson's"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amLaurie Sanders (Duke University, USA)
"LRRK2, Mitochondrial DNA Damage and Biomarkers"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amAndrew West (University of Alabama at Birmingham, USA)
"LRRK2 Inhibition in Mediating Alpha-Synuclein Neurotoxicity"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmPatrick Lewis (Institute of Neurology, University College London, United Kingdom)
"LRRK2 and Macroautophagy: Standing at a Crossroads for Human Disease"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Biology of Aging and Parkinson's Disease
Discussion Leader: Roberta Brinton (University of Southern California, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmAndrew Yoo (Washington University School of Medicine, USA)
"Generation of Human Neurons by microRNA-Based Neuronal Reprogramming and Modeling of Neurodegeneration"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmLate-Breaking Topic
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmLate-Breaking Topic
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Handling and Trafficking
Discussion Leader: David Sulzer (Columbia University Medical School, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amVictoria Bolotina (Boston University School of Medicine, USA)
"PARK14-Dependent Calcium Signaling Is a New Determinant of Autophagic Dysfunction, a-Synuclein Aggregation and PD"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amPatrik Brundin (Van Andel Institute, USA)
"Propagation of Alpha-Synuclein Pathology Along Neural Pathways"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amRobert Burke (Columbia University, USA)
"Signaling Pathways for New Axon Growth in Adult Dopamine Neurons"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amTiago Outeiro (University Medical Center Goettingen, Germany)
"Molecular Determinants of Alpha-Synuclein Handling in the Cell"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmLate-Breaking Topic
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmParkinson's Disease Models: Improving Predictive Value
Discussion Leader: Erwan Bezard (University of Bordeaux, France)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmMassimiliano Caiazzo (Utrecht University, The Netherlands)
"Generation of Dopaminergic Systems by Means of Neuronal Transdifferentiation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmBenjamin DeHay (Institute of Neurodegenerative Diseases, France)
"Prion-Like Dissemination of Human Brain-Derived Alpha-Synuclein in Mice and Monkeys"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAmber Van Laar (University of Pittsburgh, USA)
"A Progressive, Endogenous Synucleinopathy Model of Parkinson's Disease"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSNCA: From Protein, Through Cell Biology to Therapeutic Intervention
Discussion Leader: Robert Nussbaum (University of California, San Francisco, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amRudolf Jaenisch (Massachusetts Institute of Technology, USA)
"iPS Cell Technology and the Study of Simple and Complex Diseases"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amRonald Melki (Paris-Saclay Institute of Neuroscience, France)
"Prion-Like Propagation of Alpha-Synuclein Assemblies in Synucleinopathies"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amEdward Burton (University of Pittsburgh School of Medicine, USA)
"Alpha-Synuclein Knockdown Is a Promising Therapeutic Strategy for Parkinson's Disease"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amFrederic Manfredsson (Michigan State University, USA)
"Removal of Alpha-Synuclein from Mature Nigral Neurons In Vivo Results in Toxicity and Neurodegeneration"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmJesse Cederbaum (Biogen, USA)
"The Aducanumab Story: Lessons Learned from Early-Phase Anti-Amyloid mAb Development for Design of PD Clinical Trials"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSilke Nuber (Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital / Harvard Medical School, USA)
"Shifting Synuclein Tetramers to Monomers Yields Mice with p-Syn Deposits, TH Loss, Tremor, and Motor Deficits Responsive to L-DOPA"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmInflammation and Immunity in Parkinson's Disease
Discussion Leader: Malu Tansey (Emory University, USA)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 6:00 pmEtienne Hirsch (Institut du Cerveau et de la Moelle Epinière / INSERM UMR1127, CNRS, UMR7225, France)
"Neuroinflammation in Parkinson's Disease"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:30 pmJau-Shyong Hong (National Institute of Environmental Health Sciences, NIH, USA)
"Models, Mechanisms, and Therapeutic Interventions"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmMarina Romero-Ramos (NEURODIN, Aarhus University, Denmark)
"The Dynamic Immune Response in PD"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmShort Talk Selected from Poster Abstracts
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Neurological Disorders And Stroke of National Institutes of Health under Award Number R13NS100272. The content is solely the responsibility of the authors and does not necessarily represent official views of the National Institutes of Health.
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