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Parkinson's Disease
Gordon Research Conference

Integrating Diverse Research to Address Critical Issues in Parkinson's Disease

Dates

June 25-30, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chair:
Andrew Singleton

Vice Chair:
J. Timothy Greenamyre

Meeting Description

The Gordon Research Conference on Parkinson's disease is a unique meeting within the field that brings together scientists across myriad disciplines and from varied backgrounds and positions around the common theme of Parkinson's disease research. The aim of the meeting is to stimulate debate, raise questions of critical importance, exchange information, and create an atmosphere that encourages collaboration and collegiality. This meeting will focus on creating connections across disciplines, between scientists from academic, government, and pharmaceutical research groups, and researchers, from those new to the area through to the thought leaders in the field.

The field of Parkinson's disease research has matured tremendously over the last 20 years, in large part much of this progress has been driven by genetic and molecular insights into disease etiology and pathogenesis. This conference aims to bring together scientists interested in understanding the underlying disease processes with an eye toward effecting the development and deployment of etiologic based therapeutics.

Related Meeting

This GRC was held in conjunction with the "Parkinson's Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Informing Etiology Through the Clinic
Discussion Leader: Warren Olanow (Icahn School of Medicine at Mount Sinai, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:15 pmIntroduction by Discussion Leader
8:15 pm - 9:00 pmWilliam Langston (The Parkinson's Institute, USA)
"What Is Parkinson's Disease and Why Is It Important for Understanding Biology"
9:00 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmParkinson's Disease Genetics and Systems Biology
Discussion Leader: John Hardy (University College London, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amRoy Alcalay (Columbia University, USA)
"Glucocerebrosidase, Glycosphingolipids and Parkinson's Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amMichel Desjardins (Universite de Montreal, Canada)
"Autoimmune Mechanisms in Parkinson's Disease"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amSteven Finkbeiner (University of California, San Francisco, USA)
"Applications of Functional Genomics to Parkinson's Disease"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amPeter Heutink (German Center for Neurodegenerative Diseases / University of Tübingen, Germany)
"High-Content Screening and Genomic Approaches for PD"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmMatt LaVoie (Brigham and Women's Hospital / Harvard Medical School, USA)
"Genetics and Biology of Nigral Vulnerability"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPablo Sardi (Genzyme, a Sanofi Company, USA)
"Targeting Lysosomal GBA Deficiency for Parkinson's Disease: From Genetics to Therapeutics"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Roberta Brinton (University of Arizona, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGene-Environment Interaction
Discussion Leader: Jeff Bronstein (University of California, Los Angeles, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmGary Miller (Emory University, USA)
"Advancing Parkinson's Disease Research by Using Clues from the Environment"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmJason Richardson (Northeast Ohio Medical University, USA)
"Gene-Environment Interactions in PD: Role of Efflux Transporters"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmBeate Ritz (University of California, Los Angeles, USA)
"Assessing Gene-Environment Interactions: Success Stories in Parkinson's Disease"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmSelected from Poster Abstracts: Elizabeth Kline (Emory University, USA)
"Synergy Between Common Genetic Variant in Antigen Presentation Capacity and Pyrethroid Exposure Affects Peripheral Immunophenotype and Nigrostriatal Pathway Vulnerability"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLRRK2: From Protein, Through Cell Biology to Therapeutic Intervention
Discussion Leader: Marco Baptista (The Michael J. Fox Foundation for Parkinson's Research, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amDario Alessi (University of Dundee, United Kingdom)
"New Assays and Pathways that Activate LRRK2"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amPatrick Lewis (University of Reading, United Kingdom)
"LRRK2 and Macroautophagy: Standing at a Crossroads for Human Disease"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amLaurie Sanders (Duke University, USA)
"LRRK2, Mitochondrial DNA Damage and Biomarkers"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amAndrew West (University of Alabama at Birmingham, USA)
"LRRK2 Inhibition in Mediating Alpha-Synuclein Neurotoxicity"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmMatthew Kennedy (Merck & Co., USA)
"Challenges of Neurodegenerative Disease Drug Discovery: BACE Inhibitors for Alzheimer's Disease vs. LRRK2 Inhibitors for Parkinson's"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Bahareh Behrouz (NeuroInitiative, USA)
"Searching for Druggable Targets Using In Silico Simulation of LRRK2 Pathways"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Biology of Aging and Parkinson's Disease
Discussion Leader: Roberta Brinton (University of Arizona, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmAndrew Yoo (Washington University School of Medicine, USA)
"Generation of Human Neurons by microRNA-Based Neuronal Reprogramming and Modeling of Neurodegeneration"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmJeremy Van Raamsdonk (Van Andel Research Institute, USA)
"Targeting Molecular Pathways of Aging as a Treatment Strategy for Parkinson's Disease"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmRichard Morimoto (Northwestern University, USA)
"Proteostasis in Biology, Aging, and Disease"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmSelected from Poster Abstracts: Victor Van Laar (University of Pittsburgh, USA)
"Evidence for Compartmentalized Changes in Neuronal Mitochondrial Biogenesis in a PD-Relevant Model: Assessment of Mitochondrial DNA Replication in Neuron Cell Bodies, Axons, and Dendrites"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Handling and Trafficking
Discussion Leader: David Sulzer (Columbia University Medical Center, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amVictoria Bolotina (Boston University School of Medicine, USA)
"PARK14-Dependent Calcium Signaling Is a New Determinant of Autophagic Dysfunction, a-Synuclein Aggregation and PD"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amPatrik Brundin (Van Andel Institute, USA)
"Propagation of Alpha-Synuclein Pathology Along Neural Pathways"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amRobert Burke (Columbia University, USA)
"Signaling Pathways for New Axon Growth in Adult Dopamine Neurons"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amTiago Outeiro (University Medical Center Goettingen, Germany)
"Molecular Determinants of Alpha-Synuclein Handling in the Cell"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmDarren Moore (Van Andel Research Institute, USA)
"Mechanisms of VPS35-Dependent Neurodegeneration in PD"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Diana Matheoud (Universite de Montreal, Canada)
"A Link Between Infection, Autoimmune Mechanisms and Parkinson's Disease"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmParkinson's Disease Models: Improving Predictive Value
Discussion Leader: Erwan Bezard (University of Bordeaux, France)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmMassimiliano Caiazzo (Utrecht University, The Netherlands)
"Generation of Dopaminergic Systems by Means of Neuronal Transdifferentiation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmBenjamin DeHay (Institute of Neurodegenerative Diseases, France)
"Prion-Like Dissemination of Human Brain-Derived Alpha-Synuclein in Mice and Monkeys"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAmber Van Laar (University of Pittsburgh, USA)
"A Progressive, Endogenous Synucleinopathy Model of Parkinson's Disease"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmSelected from Poster Abstracts: Sonia George (Van Andel Institute, USA)
"Microglia Influences Prion-Like Propagation of Alpha-Synuclein"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSNCA: From Protein, Through Cell Biology to Therapeutic Intervention
Discussion Leader: Dennis Selkoe (Brigham and Women's Hospital, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amRudolf Jaenisch (Whitehead Institute for Biomedical Research, USA)
"iPS Cell Technology and the Study of Simple and Complex Diseases"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amRonald Melki (CNRS, France)
"Prion-Like Propagation of Alpha-Synuclein Assemblies in Synucleinopathies"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amFrederic Manfredsson (Michigan State University, USA)
"Removal of Alpha-Synuclein from Mature Nigral Neurons In Vivo Results in Toxicity and Neurodegeneration"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amEdward Burton (University of Pittsburgh School of Medicine, USA)
"Alpha-Synuclein Knockdown Is a Promising Therapeutic Strategy for Parkinson's Disease"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmJesse Cederbaum (Biogen, USA)
"The Aducanumab Story: Lessons Learned from Early-Phase Anti-Amyloid mAb Development for Design of PD Clinical Trials"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSilke Nuber (Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital / Harvard Medical School, USA)
"Shifting Synuclein Tetramers to Monomers Yields Mice with p-Syn Deposits, TH Loss, Tremor, and Motor Deficits Responsive to L-DOPA"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmInflammation and Immunity in Parkinson's Disease
Discussion Leader: Malu Tansey (Emory University, USA)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 6:00 pmEtienne Hirsch (Institut du Cerveau et de la Moelle Epinière / INSERM UMR1127, CNRS, UMR7225, France)
"Neuroinflammation in Parkinson's Disease"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:30 pmJau-Shyong Hong (National Institute of Environmental Health Sciences, NIH, USA)
"Models, Mechanisms, and Therapeutic Interventions"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmMarina Romero-Ramos (NEURODIN, Aarhus University, Denmark)
"The Dynamic Immune Response in PD"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmSelected from Poster Abstracts: Valerie Joers (Emory University, USA)
"Modulation of Inflammation via Cannabinoid Type 2 Receptors to Protect Against Asyn-Induced Degeneration"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Neurological Disorders And Stroke of National Institutes of Health under Award Number R13NS100272. The content is solely the responsibility of the authors and does not necessarily represent official views of the National Institutes of Health.
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