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Translation Machinery in Health & Disease
Gordon Research Conference

Decoding Translation for Homeostasis

Dates

March 19-24, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Sunghoon Kim

Vice Chair:
Susan L. Ackerman

Meeting Description

Protein translation is one of the most fundamental and important biological processes, involving numerous cellular components and energy. Although this process has been intensively studied for several decades, the regulation and pathophysiological relevance of translation to other cellular processes and diseases are not clearly understood. A broad spectrum of diseases—including cancer, infectious and immunological diseases, hematological and vascular diseases, neurological diseases, and metabolic diseases—are caused by defective translation and alterations in the translation apparatus. Thanks to the rapid technological advances in the studies of translational machinery including the ribosome, research on translation is rapidly expanding. This conference provides the best platform in which scientists and clinicians can exchange and obtain state-of-the-art information on the relevance of translation to human disease and health. The 2017 Translation Machinery in Health and Disease Gordon Research Conference is the first disease-focused conference for the broad field of protein translation. It covers areas that are not addressed by any existing conferences that are mainly focused on the fundamental mechanisms of components in protein synthesis and regulation. By bringing diverse research communities to a single site and facilitating the communication and translation of basic research to clinical applications, this conference will have significant value to the research community. Each session will focus on a specific disease area, and blend basic science on translation and the translational machinery with dysregulation of these pathways in pathological processes. Thus overlapping interests of both clinicians and basic scientists in translation-related molecules and diseases will be discussed at this meeting, with the likely synergistic emergence of new ideas, new avenues of research, and new leads for development of therapeutics.

Related Meeting

This GRC was held in conjunction with the "Translation Machinery in Health & Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Opening the New World of Translation
Discussion Leader: Sunghoon Kim (Seoul National University, South Korea)
7:40 pm - 8:25 pmNahum Sonenberg (McGill University, Canada)
"Translational Control of Cancer and Neurodevelopmental Disease via eIF4E"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmC. Thomas Caskey (Baylor College of Medicine, USA)
"Genetic Risk Identification for Disease Prevention"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPost-Transcriptional Regulation in Cancer
Discussion Leader: Robert Schneider (New York University School of Medicine, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amKatherine Borden (University of Montreal, Canada)
"Targeting the Multiple Lives of eIF4E in Leukemia"
9:25 am - 9:30 amDiscussion
9:30 am - 9:50 amRaul Mendez (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"The CPEB-Family of RNA-Binding Proteins, New Functions in Cell Cycle and Cancer"
9:50 am - 9:55 amDiscussion
9:55 am - 10:05 amSelected from Poster Abstracts: Maria Hatzoglou (Case Western Reserve University, USA)
"Unique Program of Adaptive ER Proteostasis During Chronic ER Stress"
10:05 am - 10:10 amDiscussion
10:10 am - 10:35 amCoffee Break
10:35 am - 10:55 amDavide Ruggero (University of California, San Francisco, USA)
"Translating the Cancer Genome One Codon at a Time and Its Therapeutic Implications"
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amEstela Jacinto (Robert Wood Johnson Medical School, Rutgers University, USA)
"mTORC2 in Cell Metabolism"
11:20 am - 11:25 amDiscussion
11:25 am - 11:45 amJung Min Han (Yonsei University, South Korea)
"Leucyl-tRNA Synthetase as a Novel Target Against Rapamycin-Resistant Cancers"
11:45 am - 11:50 amDiscussion
11:50 am - 12:10 pmMaria Barna (Stanford University, USA)
"Ribosome Heterogeneity in Translating the Genetic Code"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Ania Wilczynska (MRC Toxicology Unit, United Kingdom)
"Recruitment of eIF4A2 and DDX6 by the Ccr4-NOT Complex Enforces Distinct Modes of Translational Repression"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMetabolic Diseases
Discussion Leader: Andrew Weyrich (University of Utah School of Medicine, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmJohn Blenis (Weill Cornell Medicine, USA)
"mTOR, Metabolism and Therapeutic Opportunities"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmVadim Gladyshev (Brigham and Women's Hospital, Harvard Medical School, USA)
"Translation in Aging and Selenium Metabolism"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmScot Kimball (Penn State College of Medicine, USA)
"Modulation of Protein Synthesis as a Mechanism for Regulating Skeletal Muscle Growth and Atrophy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmPaul Fox (Cleveland Clinic, USA)
"Glu-Pro tRNA Synthetase in mTOR Signaling and Adiposity"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInfectious and Inflammatory Diseases
Discussion Leader: Michael Ibba (The Ohio State University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amNancy Woychik (Rutgers University, USA)
"tRNAs, Translation and Tuberculosis"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amMirim Jin (Gachon University, South Korea)
"Secretion of a Protein Synthesis Enzyme as a Primary Defense Mechanism Against Pathogenic Challenges"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Marat Yusupov (Institute of Genetics and Molecular and Cellular Biology (IGBMC), France)
"Structural Basis for the Inhibition of the Eukaryotic Ribosome"
10:15 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:05 amAlexander Mankin (University of Illinois at Chicago, USA)
"An Antibiotic that Inhibits Termination of Translation by Trapping Release Factors on the Ribosome"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amKarin Musier-Forsyth (The Ohio State University, USA)
"Role of Aminoacyl-tRNA Synthetases in Retroviral Replication"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmAndrew Mouland (Lady Davis Institute / McGill University, Canada)
"Identifying the Locales for Retroviral mRNA Translation"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Rafael Kroon Campos (Duke University / University of Texas Medical Branch, USA)
"Identification of Ribosomal Stalk Proteins that Are Essential for Translation of Flavivirus Genomes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslational Control of Cancer Cells
Discussion Leader: Davide Ruggero (University of California, San Francisco, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmJerry Pelletier (McGill University, Canada)
"Targeting eIF4F-Dependencies in Cancer"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRobert Schneider (New York University School of Medicine, USA)
"Translational Control of the Breast Cancer Initiating Cell"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmStephane Pyronnet (Cancer Research Center of Toulouse, France)
"Translational Control of Pancreatic Function and Carcinogenesis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmIvan Topisirovic (Lady Davis Institute, McGill University, Canada)
"Translational Control of Cancer Energetics"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Kevin Webster (eFFECTOR Therapeutics, USA)
"Selective Therapeutic Intervention in mRNA Translation as a Novel Strategy to Treat Cancer"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurological Disorders
Discussion Leader: Tao Pan (The University of Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amSusan Ackerman (University of California, San Diego, USA)
"Translational Defects and Neurodegeneration"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amSamie Jaffrey (Weill Cornell Medicine, USA)
"Control of Neuronal mRNA Translation by m6A and m6Am"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Peter Todd (University of Michigan, USA)
"RAN Translation in C9orf72 Repeat Expansion Associated Neurodegeneration"
10:15 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:05 amJoel Richter (University of Massachusetts Medical School, USA)
"Translational Control of the Fragile X Syndrome"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Robert Burgess (The Jackson Laboratory, USA)
"Mutations in Mouse Glycyl tRNA Synthetase: Profiling Transcription and Translation and Preclinical Studies"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amXiang-Lei Yang (The Scripps Research Institute, USA)
"Aminoacyl-tRNA Synthetase in Charcot-Marie-Tooth Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Jennifer Darnell (The Rockefeller University, USA)
"Translational Repression by FMRP: Association with Neuronal Type-Specific mRNA Targets and Specific Binding to Stalled Ribosomes"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Hong Joo Kim (St. Jude Children's Research Hospital, USA)
"Disturbance of RNA Granule Dynamics in Neurological Disease"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmTranslational Responses to Stress
Discussion Leader: Xiang-Lei Yang (The Scripps Research Institute, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmNilabh Shastri (University of California, Berkeley, USA)
"Translational Control in Immune Surveillance"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmTao Pan (The University of Chicago, USA)
"Dynamic tRNA Biology in the Microbiome"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmShu-Bing Qian (Cornell University, USA)
"Translational Control in Heat Shock Response"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmMichael Ibba (The Ohio State University, USA)
"Translation Quality Control and Stress Response in Bacteria"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInnovative Technologies for Translation Research
Discussion Leader: Robert Singer (Albert Einstein College of Medicine, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amHiroaki Suga (University of Tokyo, Japan)
"A RaPID Way to Discover Pseudo-Natural Peptides Against Non-Druggable Targets"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amWenshe Liu (Texas A&M University, USA)
"Study Posttranslational Nucleosomal Modifications with an Expanded Genetic Code"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Iris Alroy (Anima Biotech Ltd., Israel)
"Screening for Protein Synthesis Modulators Using Fluorescent-Labeled tRNAs"
10:15 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:05 amBin Wu (Johns Hopkins University School of Medicine, USA)
"Watching mRNA Translate"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amJeffrey Chao (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"A TRICK for Imaging Translation"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmNicholas Ingolia (University of California, Berkeley, USA)
"Global Profiling of Translation Regulation and Dysregulation"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Kyle Cottrell (Washington University School of Medicine, USA)
"Probing miRNA and RBP Function with CRE-seq"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVascular and Hematologic Disorders
Discussion Leader: Paul Fox (Cleveland Clinic, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmAndrew Weyrich (University of Utah School of Medicine, USA)
"Translational Functions of Anucleate Platelets in Health and Disease"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmMyung Hee Kim (Korea Research Institute of Bioscience and Biotechnology (KRIBB), South Korea)
"Control of Translational Initiation by a Human tRNA Synthetase"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmJie Jia (Cleveland Clinic, USA)
"Co-Translational Complex Assembly in Macrophages"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmSelected from Poster Abstracts: Naoya Kenmochi (University of Miyazaki, Japan)
"Decreased Translational Efficiency of mRNAs Required for Hematopoiesis in a Zebrafish Model of Diamond-Blackfan Anemia"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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