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Atherosclerosis (GRS)
Gordon Research Seminar

Novel Insights into Cellular, Genetic and Metabolic System Interactions

Dates

June 17-18, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chairs:
Andrew Sage & Sylvia Nuernberg

Meeting Description

The Gordon Research Seminar on Atherosclerosis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The overarching goal is to provide a forum for leading and emerging scientists to interact informally, discuss the latest discoveries and ideas, and to provide an overview of current research themes in the atherosclerosis field. We aim to provide a platform for young investigators to interact and represent their latest research in a peer-to-peer environment that also includes for the first time career training elements. We expect discussion about novel data on atherogenesis pathways, such as endothelial dysfunction, imbalanced lipid metabolism and clearance, innate immune memory, maladaptive immune responses and the interplay between inflammation and plaque complication.

Related Meeting

This GRS was held in conjunction with the "Atherosclerosis" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Wanted Dead or Alive: Inflammatory Macrophages in Vascular Disease
Discussion Leader: Andrew Sage (University of Cambridge, United Kingdom)
3:45 pm - 4:25 pmKatey Rayner (University of Ottawa Heart Institute, Canada)
"Wanted Dead or Alive: Inflammatory Macrophages in Vascular Disease"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLipids, Macrophages and Inflammation
Discussion Leader: Holger Winkels (La Jolla Institute for Allergy and Immunology, USA)
7:30 pm - 7:45 pmBastian Ramms (University of California, San Diego, USA)
"Apolipoprotein E Determines the Functional and Atherosclerotic Fate of Apolipoprotein C-III"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmXin Bi (University of Pennsylvania, USA)
"C6orf106, a Novel Plasma Lipid Locus in Humans, Regulates Lipoprotein Metabolism and Atherogenesis in Mice"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAda Weinstock (New York University School of Medicine, USA)
"Novel Regulation of Macrophage Polarization and Atherosclerosis Regression by Wnt"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMandy van Leent (Icahn School of Medicine at Mount Sinai, USA)
"Targeted CD40-TRAF6 Inhibition Resolves Macrophage Accumulation in Atherosclerosis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShuang Zhang (Northwestern University, USA)
"Mitochondrial-Directed Macrophage Reprogramming During Efferocytosis and Post Myocardial Infarction"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmCameron McAlpine (Massachusetts General Hospital, USA)
"Sleep Restricts Hematopoiesis and Protects Against Atherosclerosis"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Paradigms for Atherosclerosis Drug Discovery
Discussion Leader: Isabel Schellinger (Heart Research Center Göttingen, Germany)
9:00 am - 9:15 amRichard Bayliss (University of Virginia, USA)
"SMC Appear to be the Primary Cell Type Responding to IL1β Within Atherosclerotic Lesions"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amEva Kritikou (Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands)
"Hypercholesterolemia Induces a Mast Cell-CD4+ T-Cell Interaction in Atherosclerosis"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amAnnelie Shami (Academic Medical Center, University of Amsterdam, The Netherlands)
"GITR Activation Promotes Regulatory CD4+ T-Cell Responses and Stimulates Leukocyte Recruitment in Atherosclerotic Plaques"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amMax Senders (Icahn School of Medicine at Mount Sinai, USA)
"Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Experimental Atherosclerosis"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amVikram Shende (California Institute for Biomedical Research, USA)
"Identification of Small Molecule Suppressors of PCSK9 for the Treatment of Hypercholesterolemia"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amRhogerry Deshycka (Whitehead Institute for Biomedical Research, USA)
"Engineered Red Blood Cells Carrying PCSK9 Inhibitors as Cholesterol Blockbuster"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Taking the Next Step in Your Research Career
Discussion Leader: Sylvia Nuernberg (University of Pennsylvania, USA)
1:30 pm - 1:50 pmMichelle Olive (National Heart, Lung, and Blood Institute, NIH, USA)
"Sourcing Support for Your Research"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmLauren Celano (Propel Careers, USA)
"Smooth Transitions – Moving to a Career Outside of Academia"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL137211-01 from the National Heart, Lung and Blood Institute.The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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