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Cardiac Arrhythmia Mechanisms (GRS)
Gordon Research Seminar

Model Systems, Emerging Technologies and Precision Medicine in Arrhythmia Research and Therapeutic Development

Dates

February 4-5, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Emily L. Ongstad & Nicole M. De Jesus

Meeting Description

The Gordon Research Seminar on Cardiac Arrhythmia Mechanisms is a unique platform for graduate students, postdoctoral fellows, and other early career scientists to present unpublished data, expand their scientific network, and engage in valuable discussion about novel, cutting edge ideas in a welcoming and highly interactive environment.

The focus of this meeting is (1) to provide early career scientists with opportunities to network with their peers in an informal setting, (2) to provide presentation opportunities among fellows conducting congruent research, and (3) to offer a forum to discuss potential career paths and learn from experienced established senior and junior scientists.

In order to promote a multidisciplinary meeting, we encourage submissions spanning a wide range of cardiovascular research, incorporating a plethora of techniques, from single molecules to the whole organism. We highly encourage GRS attendees to participate in the associated GRC.

This meeting will feature a keynote presentation by Professor Colleen Clancy, PhD (Department of Pharmacology, University of California, Davis) and a career development panel with a number of selected speakers spanning the field.

Related Meeting

This GRS was held in conjunction with the "Cardiac Arrhythmia Mechanisms" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Building an Academic Career
Discussion Leaders: Nicole De Jesus (Stanford University, USA) and Emily Ongstad (MedImmune, USA)
3:45 pm - 4:15 pmColleen Clancy (University of California, Davis, USA)
"Building an Academic Career from Post-Doc to Dean's Office in 20 Easy Steps"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmConduction, Pacemaking, and Arrhythmias
Discussion Leaders: Mathilde Rivaud (University Medical Center Utrecht, The Netherlands) and Sharon George (George Washington University, USA)
7:30 pm - 7:40 pmDrew Nassal (Case Western Reserve University, USA)
"KChIP2 Is a Key Transcriptional Regulator of Cardiac Excitability"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmDavid Jones (University of Wisconsin-Madison, USA)
"A Novel Interacting Protein Regulates Repolarizing IKr Current in the Heart"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmEilidh MacDonald (Dalhousie University, Canada)
"Stretch Effects on Pacemaker Activity in Zebrafish"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAxel Loewe (Karlsruhe Institute of Technology, Germany)
"Influence of Electrolyte Concentration Changes on Sinus Node Function - A New Player Regarding Sudden Cardiac Death in Patients with Chronic Kidney Disease?"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmNele Vandersickel (Ghent University, Belgium)
"Different Mechanisms of Torsade de Pointes Arrhythmias in the Drug-Induced Chronic AV Block Dog"
8:40 pm - 8:45 pmDiscussion
Modeling in Disease and Drug Development
8:45 pm - 8:55 pmSara Dutta (Food and Drug Administration, USA)
"Optimization of an In Silico Cardiac Cell Model for Proarrhythmia Risk Assessment Using hERG-Drug Binding Kinetics and Multi-Channel Pharmacology"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMichael Liu (University of California, Los Angeles, USA)
"T-Wave Alternans and Lability in the Initiation of Ventricular Arrhythmias Caused by QT Prolongation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAnna Muszkiewicz (University of Oxford, United Kingdom)
"Whole Atria Mechanisms of Inducibility and Persistence of Atrial Fibrillation by Depletion of nNOS in Human"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Approaches in Arrhythmia Diagnosis and Treatment
Discussion Leader: Francis Ortega (Weill Cornell Medical College, USA)
9:00 am - 9:10 amTobias Bruegmann (University of Bonn, Germany)
"Optogenetic Termination of Atrial Fibrillation in the Mouse Heart"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amMonique Windley (The Victor Chang Cardiac Research Institute, Australia)
"Investigating the Temperature Dependency of hERG Drug Block Kinetics and Potency: Implications for High Throughput Screening Assays and In Silico Proarrhythmic Risk Prediction"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amJan Christoph (Max Planck Society, Germany)
"Ultrasound-Based Mapping of Electromechanical Rotors During Cardiac Fibrillation"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amWandi Zhu (Washington University in St. Louis, USA)
"A Novel Mechanism for the Prediction of Gene-Specific Sensitivity to Class-Ib Antiarrhythmic Mexiletine"
9:55 am - 10:00 amDiscussion
Mentorship Component: Career Panels
10:00 am - 10:30 amPanel Discussion
"Early Career Development"
  • Peng-Sheng Chen (Indiana University School of Medicine, USA)
  • Eleonora Grandi (University of California, Davis, USA)
  • Colleen Clancy (University of California, Davis, USA)
10:30 am - 11:00 amPanel Discussion
"Non-Academic Careers"
  • David Lathrop (National Heart, Lung, and Blood Institute, NIH, USA)
  • Najah Abi Gerges (AnaBios Corporation, USA)
  • Jiansong Sheng (U.S. Food and Drug Administration, USA)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCardiac Innervation
Discussion Leader: Colin Peters (Simon Fraser University, Canada)
1:30 pm - 1:40 pmStephanie Anderson (University of Glasgow, United Kingdom)
"Differential Chronotropic and Inotropic Effects of Left and Right Stellate Ganglion Stimulation in the Innervated Rabbit Heart"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmJakub Tomek (University of Oxford, United Kingdom)
"An Anti-Arrhythmic Potential of Infarct Border Zone Sympathetic Innervation via Alternans Attenuation"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmMatthew Stoyek (Dalhousie University, Canada)
"Regulation of Pacemaker Function by the Intracardiac Cardiac Nervous System in Zebrafish"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award Number 1R13HL136006-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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