|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: Enzyme Inhibition and Drug Design|
|Discussion Leader: Zhen Wang (Albert Einstein College of Medicine, USA)|
|3:45 pm - 4:15 pm||Thomas Meek (Texas A&M University, USA)|
"Rational Design of Enzyme Inhibitors as a Last Resort for Drug Discovery"
|4:15 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Learning from Nature: How Enzymes Work|
|This session focuses on fundamental aspects of enzyme mechanisms. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.|
|Discussion Leader: Tatiana Mishanina (University of Wisconsin-Madison, USA)|
|7:30 pm - 7:50 pm||Jonathan Musila (Auburn University, USA)|
"FMN Reductase of Alkanesulfonate Monooxygenase System: Role of pi-Helix and Flavin-Induced Oligomeric Switch"
|7:50 pm - 8:00 pm||Discussion|
|8:00 pm - 8:20 pm||Svetlana Kholodar (University of Iowa, USA)|
"Challenging the Traditional Mechanism of Thymidylate Synthase"
|8:20 pm - 8:30 pm||Discussion|
|8:30 pm - 8:50 pm||Evan Judd (Novartis Institutes for BioMedical Research, USA)|
"How Does a Chromatin Remodeler Move? Investigating How Accessory Domains Tune the Function of BRM/BRG1"
|8:50 pm - 9:00 pm||Discussion|
|9:00 pm - 9:20 pm||Kanishk Kapilashrami (Memorial Sloan Kettering Cancer Center, USA)|
"Kinetic Isotope Effects Uncover Transition States of Protein Lysine Methyltransferases"
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Pushing the Limits: Applications of Enzymology and Studies of Metabolic Pathways|
|This session focuses on applications of knowledge learned by studying enzymes and metabolic pathways. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.|
|Discussion Leader: Myles Poulin (Albert Einstein College of Medicine, USA)|
|9:00 am - 9:20 am||Juliana Martinez (Florida State University, USA)|
"Allokairic Regulation of Enzyme Function"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Shijie Huang (University of New Mexico, USA)|
"In Vivo Detection and Quantification of Ribosome Inhibition and Directed Evolution of Ribosomal RNA Variants"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Romila Mascarenhas (Loyola University Chicago, USA)|
"Elucidating the Mechanism of Inactivation of PLP Dependent Drug Targets – Ornithine Aminotransferase and GABA Aminotransferase, and Comparison with a Non-Drug Target-Asp-AT"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Ken Ellens (University of Luxembourg, Luxembourg)|
"CLYBL as a Missing Piece of the Metabolite Repair Puzzle"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: Leverage Your Scientific Training to Find Your Dream Career|
|This session serves as the career development discussion panel of the conference. The panelists include junior and veteran investigators in academia and industry, as well as experts in non-traditional careers. They will discuss different career paths, offer advice on career development, and answer questions from conference attendees.|
|Discussion Leader: Crystal Smitherman (Aalto Scientific, Ltd., USA)|
|1:30 pm - 2:30 pm||Panel Discussion|
|"Academia, Industry, and Alternative Career Paths"|
- Squire Booker (Pennsylvania State University, USA)
- Lauren Celano (Propel Careers, USA)
- Catherine Goodman (Journal of Biological Chemistry, USA)
- Randy Kipp (Relay Therapeutics, USA)
- Thomas Meek (Texas A&M University, USA)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|