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Enzymes, Coenzymes & Metabolic Pathways (GRS)
Gordon Research Seminar

Enzymology in the 21st Century: New Concepts, Methods, and Systems

Dates

July 23-24, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Zhen Wang

Meeting Description

The Gordon Research Seminar on Enzymes, Coenzymes and Metabolic Pathways is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The 2016 GRS will highlight the latest advances in enzymology from the fundamentals of determining enzyme function to the interplay of complex enzyme systems. This meeting will also emphasize career development, by including a panel involving representatives from academia, industry, and non-traditional careers, as well as providing multiple opportunities to network in a casual, stimulating environment.

Related Meeting

This GRS was held in conjunction with the "Enzymes, Coenzymes & Metabolic Pathways" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Enzyme Inhibition and Drug Design
Discussion Leader: Zhen Wang (Albert Einstein College of Medicine, USA)
3:45 pm - 4:15 pmThomas Meek (Texas A&M University, USA)
"Rational Design of Enzyme Inhibitors as a Last Resort for Drug Discovery"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLearning from Nature: How Enzymes Work
This session focuses on fundamental aspects of enzyme mechanisms. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.
Discussion Leader: Tatiana Mishanina (University of Wisconsin-Madison, USA)
7:30 pm - 7:50 pmJonathan Musila (Auburn University, USA)
"FMN Reductase of Alkanesulfonate Monooxygenase System: Role of pi-Helix and Flavin-Induced Oligomeric Switch"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSvetlana Kholodar (University of Iowa, USA)
"Challenging the Traditional Mechanism of Thymidylate Synthase"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmEvan Judd (Novartis Institutes for BioMedical Research, USA)
"How Does a Chromatin Remodeler Move? Investigating How Accessory Domains Tune the Function of BRM/BRG1"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKanishk Kapilashrami (Memorial Sloan Kettering Cancer Center, USA)
"Kinetic Isotope Effects Uncover Transition States of Protein Lysine Methyltransferases"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPushing the Limits: Applications of Enzymology and Studies of Metabolic Pathways
This session focuses on applications of knowledge learned by studying enzymes and metabolic pathways. The Speakers and Discussion Leader were selected from conference attendees based on submitted poster abstracts.
Discussion Leader: Myles Poulin (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 amJuliana Martinez (Florida State University, USA)
"Allokairic Regulation of Enzyme Function"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amShijie Huang (University of New Mexico, USA)
"In Vivo Detection and Quantification of Ribosome Inhibition and Directed Evolution of Ribosomal RNA Variants"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amRomila Mascarenhas (Loyola University Chicago, USA)
"Elucidating the Mechanism of Inactivation of PLP Dependent Drug Targets – Ornithine Aminotransferase and GABA Aminotransferase, and Comparison with a Non-Drug Target-Asp-AT"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amKen Ellens (University of Luxembourg, Luxembourg)
"CLYBL as a Missing Piece of the Metabolite Repair Puzzle"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Leverage Your Scientific Training to Find Your Dream Career
This session serves as the career development discussion panel of the conference. The panelists include junior and veteran investigators in academia and industry, as well as experts in non-traditional careers. They will discuss different career paths, offer advice on career development, and answer questions from conference attendees.
Discussion Leader: Crystal Smitherman (Aalto Scientific, Ltd., USA)
1:30 pm - 2:30 pmPanel Discussion
"Academia, Industry, and Alternative Career Paths"
  • Squire Booker (Pennsylvania State University, USA)
  • Lauren Celano (Propel Careers, USA)
  • Catherine Goodman (Journal of Biological Chemistry, USA)
  • Randy Kipp (Relay Therapeutics, USA)
  • Thomas Meek (Texas A&M University, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible in part by 1R13AI126824-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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