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Enzymes, Coenzymes and Metabolic Pathways (GRS)
Gordon Research Seminar

New Discoveries, Mechanisms and Technologies: Advancing the Frontiers of Enzymology

Dates

July 15-16, 2017

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Crystal Smitherman Rosenberg

Meeting Description

The Gordon Research Seminar on Enzymes, Coenzymes and Metabolic Pathways is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The 2017 GRS will highlight the latest advances, innovations and new discoveries in enzymology from the fundamentals of determining enzyme function to complex enzyme mechanisms and their roles in cancer and disease. This meeting will also emphasize career development by including a panel of senior and junior leaders from academia, industry, government and beyond, as well as providing multiple opportunities to network in a casual, stimulating environment.

Related Meeting

This GRS was held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Phosphonate Biosynthesis
Discussion Leader: Crystal Smitherman Rosenberg (Aalto Scientific, Ltd., USA)
3:45 pm - 4:15 pmWilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA)
"Phosphonate Biosynthesis: A Treasure Trove for Novel Enzymology"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Fundamentals of Enzymology
Discussion Leader: Emilia Strandback (Graz University of Technology, Austria)
7:30 pm - 7:50 pmEric Koehn (University of California, Berkeley, USA)
"Characterization of PqqB: A Protein of Unknown Function Within the Pyrroloquinoline Quinone (PQQ) Biosynthetic Pathway"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJacquelyn Blake-Hedges (University of California, Berkeley, USA)
"Investigating the Regiospecificity of an Unusual Bacterial Acyl-CoA Dehydrogenase"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJohn Janetzko (Harvard Medical School, USA)
"It's a Trap! Asp/Glu Carboxylate Glycosylation of O-GlcNAc Transferase Triggers Peptide Backbone Reactions"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmErin McCarthy (Pennsylvania State University, USA)
"Destruction and Reformation of an Iron-Sulfur Cluster During Catalysis by Lipoyl Synthase"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amInnovations and Applications of Enzymology and Metabolic Pathways
Discussion Leader: Matteo Planchestainer (University of Nottingham, United Kingdom)
9:00 am - 9:20 amMaureen Hill (University of Massachusetts Amherst, USA)
"Engineered Caspases with Altered Specificities Enable Identification of Exosites"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amVanessa Chaplin (University of Massachusetts Amherst, USA)
"Engineering Alternate Radical Rebound Chemistry in Factor Inhibiting HIF (FIH)"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJames Vranish (U.S. Naval Research Laboratory, USA)
"Enhanced Catalysis of Glycolytic Pathways by Co-Localization of Enzymes on Nanoparticle Surfaces"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCathleen Zeymer (ETH Zurich, Switzerland)
"The Enzyme Mechanism of a De Novo Designed and Evolved Aldolase"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Broadening Horizons in the Scientific Career Landscape
This session serves as the career development discussion panel of the conference. The panelists include investigators in academia and industry, as well as experts in non-traditional careers. They will discuss different career paths, offer advice on career development, and answer questions from conference attendees.
Discussion Leader: Tatiana Mishanina (University of Wisconsin-Madison, USA)
1:30 pm - 2:30 pmPanel Discussion
"Broadening Horizons in the Scientific Career Landscape"
  • Kay Ahn (Janssen Research & Development, USA)
  • Holly Ellis (Auburn University, USA)
  • Stefan Gross (Agios Pharmaceuticals, USA)
  • Nicole Neuman (Trends in Biochemical Sciences, Cell Press, USA)
  • Wilfred van der Donk (Howard Hughes Medical Institute / University of Illinois at Urbana-Champaign, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible by 1R13AI133660-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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