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Mechanisms of Membrane Transport (GRS)
Gordon Research Seminar

Membrane Protein Structure, Function and Dynamics: New Ways to Answer Old Questions

Dates

June 24-25, 2017

Location

Colby-Sawyer College
New London, NH

Organizers

Chairs:
Ute A. Hellmich & Smriti Mishra

Meeting Description

The Gordon Research Seminar on Mechanisms of Membrane Transport is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will focus on technical and functional advances in membrane transport research, specifically membrane protein dynamics and protein-lipid/protein-ligand interactions. A central aspect will be on novel techniques to tackle such topics, thus delivering novel insights and discoveries relevant for processes underlying the basic chemistry of life and yielding insights into pathobiological phenomena such as substance abuse, depression, drug resistance or cancer progression. A dedicated panel discussion on different career paths with a strong focus on audience-driven discussions will also be included.

Related Meeting

This GRS was held in conjunction with the "Mechanisms of Membrane Transport" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmNew Methods to Study Old Problems – Advances in Technology
Discussion Leader: Edward Twomey (Columbia University, USA)
3:45 pm - 4:10 pmArthur Laganowsky (Texas A&M University, USA)
"Ion Mobility Mass Spectrometry of Intact Membrane Protein Complexes"
4:10 pm - 4:15 pmDiscussion
4:15 pm - 4:25 pmWei Mi (Harvard Medical School, USA)
"CryoEM Structure of the Retrotranslocon in the ERAD Pathway"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStudying Mechanisms of Membrane Proteins
Discussion Leader: Vedrana Mikusevic (Goethe University Frankfurt, Germany)
7:30 pm - 7:45 pmStephan Rempel (University of Groningen, The Netherlands)
"A New Mechanism of Vitamin B12 Transport in Bacteria"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmHundeep Kaur (Goethe University Frankfurt, Germany)
"Enzymatic and Structural Basis of Coupled ATPase-Adenylate Kinase Activity in MsbA"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmAltin Sula (Birkbeck, University of London, United Kingdom)
"The Complete Structure of an Activated Open Voltage Gated Sodium Channel Reveals a Novel Gating Interaction Motif"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmScott Jackson (ETH Zurich, Switzerland)
"Structure and Function of the Human Multidrug Transporter ABCG2"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmShai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Rigor and Transparency: The Path Taken and the Path Forward"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMentorship Component: Career Panel / New Views on Membrane Protein Dynamics
Discussion Leaders: Belinda Faust (Structural Genomics Consortium, University of Oxford, United Kingdom) and Sophie Rugg (University of York, United Kingdom)
9:00 am - 10:00 amPanel Discussion
"Navigating Complex Career Choices in Science"
  • Katharina Duerr (University of Oxford, United Kingdom)
  • Sarah Miller (National Cancer Institute, NIH / Kelly Services, USA)
  • Yan Qi (Morrison & Foerster LLP., USA)
10:00 am - 10:10 amChristoph Bock (Goethe University Frankfurt, Germany)
"TMD0 of TAPL: Solution NMR with a Membrane Embedded Accessory Domain"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amReza Dastvan (Vanderbilt University, USA)
"Proton Sensors of the E. coli Multidrug Transporter EmrE"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amWenchang Zhou (National Heart, Lung and Blood Institute, NIH, USA)
"Is the C-Subunit Ring of the F1Fo ATP Synthase the Elusive Mitochondrial Permeability Transition Pore?"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amMarina Diskowski (Goethe University Frankfurt, Germany)
"Helical Jackknives Control the Double-Pore K+ Uptake System KtrAB"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmInteractions of Membrane Proteins with Lipids and Ligands
Discussion Leader: Kerstin Kanonenberg (Heinrich Heine University Duesseldorf, Germany)
1:30 pm - 1:40 pmShannon Mostyn (University of Sydney, Australia)
"Heads or Tails: Lipid Inhibitors of the Glycine Transporter, GlyT2"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmMelissa Pinard (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Structural Insights into the TonB-Dependent Outer Membrane Transporter LutA of Hypervirulent Klebsiella pneumoniae"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmAaron Bozzi (Harvard University, USA)
"Molecular Mechanism of a Bacterial Nramp-Family Transition Metal Transporter"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmAlbert Guskov (University of Groningen, The Netherlands)
"The Structural Basis of Proton Driven Zinc Transport by ZntB"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS101878. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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