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Mechanisms of Membrane Transport (GRS)
Gordon Research Seminar

Membrane Protein Structure, Function and Dynamics: New Ways to Answer Old Questions

Dates

June 24-25, 2017

Location

Colby-Sawyer College
New London, NH Site Information

Organizers

Chairs:
Ute A. Hellmich & Smriti Mishra

Application Deadline

Applications for this meeting must be submitted by May 27, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by March 24, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description

Overview

The Gordon Research Seminar on Mechanisms of Membrane Transport is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will focus on technical and functional advances in membrane transport research, specifically membrane protein dynamics and protein-lipid/protein-ligand interactions. A central aspect will be on novel techniques to tackle such topics, thus delivering novel insights and discoveries relevant for processes underlying the basic chemistry of life and yielding insights into pathobiological phenomena such as substance abuse, depression, drug resistance or cancer progression. A dedicated panel discussion on different career paths with a strong focus on audience-driven discussions will also be included.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by March 24, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Mechanisms of Membrane Transport" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmNew Methods to Study Old Problems – Advances in Technology
Discussion Leader: Mrinal Shekhar (University of Illinois at Urbana-Champaign, USA)
3:45 pm - 4:10 pmArthur Laganowsky (Texas A&M University, USA)
"Ion Mobility Mass Spectrometry of Intact Membrane Protein Complexes"
4:10 pm - 4:15 pmDiscussion
4:15 pm - 4:25 pmWei Mi (Harvard Medical School, USA)
"CryoEM Structure of the Retrotranslocon in the ERAD Pathway"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStudying Mechanisms of Membrane Proteins
Discussion Leader: Vedrana Mikusevic (Goethe University Frankfurt, Germany)
7:30 pm - 7:40 pmStephan Rempel (University of Groningen, The Netherlands)
"A New Mechanism of Vitamin B12 Transport in Bacteria"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmHundeep Kaur (Goethe University Frankfurt, Germany)
"Enzymatic and Structural Basis of Coupled ATPase-Adenylate Kinase Activity in MsbA"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:15 pmAltin Sula (Birkbeck, University of London, United Kingdom)
"The Complete Structure of an Activated Open Voltage Gated Sodium Channel Reveals a Novel Gating Interaction Motif"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmMingfeng Tsai (Brandeis University, USA)
"Safety Upgrade of the Mitochondrial Calcium Uniporter"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmTao Jiang (University of Illinois at Urbana-Champaign, USA)
"Identification of the Ion Conduction Pathway in a TMEM16 Scramblase"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmShai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Rigor and Transparency: The Path Taken and the Path Forward"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMentorship Component: Career Panel / New Views on Membrane Protein Dynamics
Discussion Leaders: Belinda Faust (Structural Genomics Consortium, University of Oxford, United Kingdom) and Sophie Rugg (University of York, United Kingdom)
9:00 am - 10:00 amPanel Discussion
"Navigating Complex Career Choices in Science"
  • Katharina Duerr (University of Oxford, United Kingdom)
  • Sarah Miller (National Cancer Institute, NIH / Kelly Services, USA)
  • Yan Qi (Morrison & Foerster LLP., USA)
10:00 am - 10:10 amChristoph Bock (Goethe University Frankfurt, Germany)
"TMD0 of TAPL: Solution NMR with a Membrane Embedded Accessory Domain"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amReza Dastvan (Vanderbilt University, USA)
"Proton Sensors of the E. coli Multidrug Transporter EmrE"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amWenchang Zhou (National Heart, Lung and Blood Institute, NIH, USA)
"Atomistic Simulations Indicate the c-Subunit Ring of the F1Fo ATP Synthase Is Not the Mitochondrial Permeability Transition Pore"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amMarina Diskowski (Goethe University Frankfurt, Germany)
"Helical Jackknives Control the Double-Pore K+ Uptake System KtrAB"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmInteractions of Membrane Proteins with Lipids and Ligands
Discussion Leader: Kerstin Kanonenberg (Heinrich Heine University Duesseldorf, Germany)
1:30 pm - 1:40 pmShannon Mostyn (University of Sydney, Australia)
"Heads or Tails: Lipid Inhibitors of the Glycine Transporter, GlyT2"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmMelissa Pinard (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Structural Insights into the TonB-Dependent Outer Membrane Transporter LutA of Hypervirulent Klebsiella pneumoniae"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmAaron Bozzi (Harvard University, USA)
"Molecular Mechanism of a Bacterial Nramp-Family Transition Metal Transporter"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmAlbert Guskov (University of Groningen, The Netherlands)
"The Structural Basis of Proton Driven Zinc Transport by ZntB"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS101878. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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