Gordon Research Conferences
Meeting Details

Muscle: Excitation-Contraction Coupling (GRS)
Gordon Research Seminar

Emerging Concepts in Physiology and Pathophysiology of Excitation-Contraction Coupling


June 3-4, 2017


Les Diablerets Conference Center
Les Diablerets, Switzerland Site Information


John D. Lueck

Application Deadline

Applications for this meeting must be submitted by May 6, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by March 3, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description


This 2017 Gordon Research Seminar on Muscle: Excitation-Contraction Coupling will provide a unique opportunity for graduate students, post-docs, and other early career scientists with comparable levels of experience and education to show novel and unpublished results, new hypothesis and spur collaborations in the field of Muscle Excitation-Contraction Coupling.

The Gordon Research Seminar on Muscle: Excitation-Contraction Coupling aims to offer a new avenue to bring together students, postdocs and junior investigators in the field. The overall goal of the GRS is to share cutting-edge methods, techniques and novel results and to create opportunities for future collaborations. The scientific sessions, posters presentations and social events will highlight current trends on the mechanisms of Muscle: Excitation-Contraction Coupling with emphasis in its role in physiology and pathophysiology.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by March 3, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Muscle: Excitation-Contraction Coupling" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.


Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Couplon Myopathies
Discussion Leader: John Lueck (University of Iowa, USA)
3:15 pm - 3:50 pmSusan Hamilton (Baylor College of Medicine, USA)
"Couplon Myopathies: More than Just a Change in Ca2+ Release"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmExcitation-Contraction Coupling Physiology and Modulation
Discussion Leaders: Erick Hernandez-Ochoa (University of Maryland School of Medicine, USA) and Francisco Alvarado (University of Michigan, USA)
5:30 pm - 5:50 pmParisa Asghari (University of British Columbia, Canada)
"Ryanodine Tetramer Distribution in Ventricular Myocytes from Phosphomutant Mice"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmOmid Haji-Ghassemi (University of British Columbia, Canada)
"Probing the Role of PKA and CaMKII Phosphorylation on the Cardiac Ryanodine Receptor"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmManuela Lavorato (University of Pennsylvania, USA)
"Mitochondrial Fission in Fatigued Muscle"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmHanting Yang (Institute of Biophysics, Chinese Academy of Sciences, China)
"Structures and Gating Mechanisms of TRIC Channels"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amExcitation-Contraction Coupling Pathophysiology and Disease Models
Discussion Leaders: Lan Wei-LaPierre (University of Rochester Medical Center, USA) and Amy Hanna (Baylor College of Medicine, USA)
9:00 am - 9:20 amValentina Polverino (University of Siena, Italy)
"Functional Characterization of Calsequestrin1 Mutation Identified in Patients Affected by Myopathy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKevin Tylock (University of Rochester Medical Center, USA)
"Molecular and Physiological Mechanisms for QRS- and QT-Interval Prolongation in Mice with Cardiac Expression of Expanded CUG-Repeat mRNA"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMaarten Steinz (Karolinska Institutet, Sweden)
"Examining the Functional Effects of Nitrosative Stress on the Ryanodine Receptor and the Contractile Filaments from Skeletal Muscle"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amLeonela Amoasii (University of Texas Southwestern Medical Center, USA)
"Single Cut Genome Editing Restores Dystrophin Expression in a Humanized Mouse Model of Muscular Dystrophy"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leaders: Carlo Manno (Rush University Medical Center, USA) and Alexander Polster (University of Colorado Denver, USA)
1:30 pm - 2:30 pmPanel Discussion
"Career Development and Funding"
  • Aurelie Goyenvalle (Versailles Saint-Quentin-en-Yvelines University, France)
  • John Porter (Myotonic Dystrophy Foundation, USA)
  • Benjamin Prosser (University of Pennsylvania, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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