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Nucleosides, Nucleotides & Oligonucleotides (GRS)
Gordon Research Seminar

Exploring and Harnessing the Unique Properties of Nucleic Acids and Their Components

Dates

June 24-25, 2017

Location

Salve Regina University
Newport, RI

Organizers

Chairs:
Mindy K. Graham & Paritosh Pande

Meeting Description

The Gordon Research Seminar on Nucleosides, Nucleotides and Oligonucleotides is tailored for graduate students, post-docs, and other scientists with comparable levels of experience and education. Initiated in 2015, the Nucleosides, Nucleotides and Oligonucleotides GRS was established to serve as a unique forum for trainees attending the associated GRC to have the opportunity to share research findings, gain relevant feedback, and network with other trainees with overlapping research interests.

The scientific focus of the GRS meeting will be on new advances in the field – including genome editing, drug delivery, DNA repair, nucleic acid metabolism, modified nucleic acids, canonical and non-canonical base pair interactions, higher order structures of nucleic acids, and synthetic analogs of nucleosides, nucleotides and oligonucleotides. The GRS will be structured into three themed sessions followed by a strong mentorship component concentrated on career development.

Related Meeting

This GRS was held in conjunction with the "Nucleosides, Nucleotides & Oligonucleotides" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Exploring and Harnessing the Unique Properties of Nucleic Acids and Their Components
Discussion Leader: Mindy Graham (Johns Hopkins School of Medicine, USA)
3:45 pm - 4:15 pmFeng Zhang (Massachusetts Institute of Technology, USA)
"From Microbial Diversity to Molecular Technologies"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMentorship Component: Career Development Panel / Applications for Canonical and Non-Canonical Binding Interactions of Nucleotides and Oligonucleotides
Discussion Leaders: Paritosh Pande (University of Connecticut, USA) and Katherine Launer-Felty (Yale University, USA)
7:30 pm - 8:30 pmPanel Discussion
"The Career Paths of the Nucleoside, Nucleotide and Oligonucleotide Scientist"
  • David Giljohann (Exicure, USA)
  • Tracey Mason (Stevenson University, USA)
  • Feng Zhang (Massachusetts Institute of Technology, USA)
8:30 pm - 8:45 pmJia Niu (University of California, Santa Barbara, USA)
"Discovery of Carbohydrate-Nucleic Acid Hybrid Reagents for Highly Specific Lectin Recognition"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmNikita Brodyagin (Binghamton University, State University of New York (SUNY), USA)
"Recognition of Non-Coding RNA in the Cells"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Approaches in the Synthesis of Nucleic Acids and Their Modified Analogues
Discussion Leader: Xiaohong Tan (Carnegie Mellon University, USA)
9:00 am - 9:15 amVenubabu Kotikam (Binghamton University, State University of New York (SUNY), USA)
"Concurrent Hydrogenation of Three Functional Groups Enables Efficient Synthesis of 3'-Homologated Nucleoside Amino Acid Monomers for Preparation of Amide-Modified siRNAs"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amKatherine Launer-Felty (Yale University, USA)
"Enzymatic Synthesis of Cyclic Dinucleotide Analogues"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amIrina Novosjolova (Binghamton University, State University of New York (SUNY), USA)
"Synthesis, Thermal Stability and NMR Studies of Modified Watson-Crick Base Pair Analogues"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amGiacomo Padroni (University of Strathclyde, United Kingdom)
"Expanding the DNA Binding Repertoire of Py-Im Polyamides"
10:30 am - 10:40 amDiscussion
10:40 am - 10:55 amZhipu Luo (National Cancer Institute, NIH, USA)
"DNA-Urea Interaction and Urea Based DNA-Binder Design"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmApplications for Canonical and Non-Canonical Binding Interactions of Nucleotides and Oligonucleotides (continued)
Discussion Leader: Katherine Launer-Felty (Yale University, USA)
1:30 pm - 1:45 pmHeidi Dahlmann (Berry College, USA)
"Elongated Nucleoside Analogs as Probes for Detecting O6-Alkylguanine in DNA"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmSara Rouhanifard (University of Pennsylvania, USA)
"Fluorescent Amplification of Individual mRNAs in Single Cells"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmSaketh Gudipati (University of Connecticut, USA)
"Multivalent RNA Interactions for Improved Nanoparticle Delivery Targeting Efficiencies"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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