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Nucleosides, Nucleotides & Oligonucleotides (GRS)
Gordon Research Seminar

Exploring and Harnessing the Unique Properties of Nucleic Acids and Their Components

Dates

June 24-25, 2017

Location

Salve Regina University
Newport, RI Site Information

Organizers

Chairs:
Mindy K. Graham & Paritosh Pande

Application Deadline

Applications for this meeting must be submitted by May 27, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by March 24, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description

Overview

The Gordon Research Seminar on Nucleosides, Nucleotides and Oligonucleotides is tailored for graduate students, post-docs, and other scientists with comparable levels of experience and education. Initiated in 2015, the Nucleosides, Nucleotides and Oligonucleotides GRS was established to serve as a unique forum for trainees attending the associated GRC to have the opportunity to share research findings, gain relevant feedback, and network with other trainees with overlapping research interests.

The scientific focus of the GRS meeting will be on new advances in the field – including genome editing, drug delivery, DNA repair, nucleic acid metabolism, modified nucleic acids, canonical and non-canonical base pair interactions, higher order structures of nucleic acids, and synthetic analogs of nucleosides, nucleotides and oligonucleotides. The GRS will be structured into three themed sessions followed by a strong mentorship component concentrated on career development.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by March 24, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Nucleosides, Nucleotides & Oligonucleotides" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Exploring and Harnessing the Unique Properties of Nucleic Acids and Their Components
Discussion Leader: Mindy Graham (Johns Hopkins School of Medicine, USA)
3:45 pm - 4:15 pmFeng Zhang (Massachusetts Institute of Technology, USA)
"From Microbial Diversity to Molecular Technologies"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmApplications for Canonical and Non-Canonical Binding Interactions of Nucleotides and Oligonucleotides
Discussion Leader: Katherine Launer-Felty (Yale University, USA)
7:30 pm - 7:45 pmJia Niu (University of California, Santa Barbara, USA)
"Synthesis, Thermal Stability and NMR Studies of Modified Watson-Crick Base Pair Analogues"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmNikita Brodyagin (Binghamton University, State University of New York (SUNY), USA)
"Recognition of Non-Coding RNA in the Cells"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmHeidi Dahlmann (Berry College, USA)
"Elongated Nucleoside Analogs as Probes for Detecting O6-Alkylguanine in DNA"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmSara Rouhanifard (University of Pennsylvania, USA)
"Fluorescent Amplification of Individual mRNAs in Single Cells"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmSaketh Gudipati (University of Connecticut, USA)
"Multivalent RNA Interactions for Improved Nanoparticle Delivery Targeting Efficiencies"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Approaches in the Synthesis of Nucleic Acids and Their Modified Analogues
Discussion Leader: Xiaohong Tan (Carnegie Mellon University, USA)
9:00 am - 9:15 amVenubabu Kotikam (Binghamton University, State University of New York (SUNY), USA)
"Concurrent Hydrogenation of Three Functional Groups Enables Efficient Synthesis of 3'-Homologated Nucleoside Amino Acid Monomers for Preparation of Amide-Modified siRNAs"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amKatherine Launer-Felty (Yale University, USA)
"Enzymatic Synthesis of Cyclic Dinucleotide Analogues"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amIrina Novosjolova (Binghamton University, State University of New York (SUNY), USA)
"Synthesis, Thermal Stability and NMR Studies of Modified Watson-Crick Base Pair Analogues"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amGiacomo Padroni (University of Strathclyde, United Kingdom)
"Expanding the DNA Binding Repertoire of Py-Im Polyamides"
10:30 am - 10:40 amDiscussion
10:40 am - 10:55 amZhipu Luo (National Cancer Institute, NIH, USA)
"DNA-Urea Interaction and Urea Based DNA-Binder Design"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Development Panel
For the conclusion of our meeting, we will have a one-hour mentorship component with a panel focused on Career Development. This panel will include our keynote speaker, as well as representatives for academic and non-academic careers.
Discussion Leader: Paritosh Pande (University of Connecticut, USA)
1:30 pm - 2:30 pmPanel Discussion
"The Career Paths of the Nucleoside, Nucleotide and Oligonucleotide Scientist"
  • David Giljohann (Exicure, USA)
  • Tracey Mason (Stevenson University, USA)
  • Feng Zhang (Massachusetts Institute of Technology, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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