Gordon Research Conferences
Meeting Details

Vascular Cell Biology (GRS)
Gordon Research Seminar

Future Directions in Vascular Biology: Old Friends and New Players in Vessel Development and Disease


January 14-15, 2017


Four Points Sheraton / Holiday Inn Express
Ventura, CA


Natalie M. Kofler & Alexandre Dubrac

Meeting Description

The Gordon Research Seminar on Vascular Cell Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. This seminar also provides young scientists with a privileged environment for scientific exchanges, networking and career guidance.

The 2017 Vascular Cell Biology GRS will focus on new advances in research on the regulation of vascular network development and function. Healthy blood vessels require coordinated regulation of endothelial cells and the many other cell types that contribute to vessel health, such as mural cells and immune cells. In this meeting we will discuss the different players involved in establishing a functional vasculature and their implication in disease states. We will also explore how vascular cells specialize to meet the unique requirements of different organ systems. The seminar will conclude following a panel discussion on career development with leaders from academic, industry, and policy arenas. The goal of this meeting is to broaden our perspective of vascular biology in order to advance innovative research and nurture collaborative connections. Both junior investigators and trainees will have opportunities to interact informally and share views with established investigators in a collegial and relaxed atmosphere.

Related Meeting

This GRS was held in conjunction with the "Vascular Cell Biology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Mechanisms and Mechanics in Vascular Patterning
Discussion Leader: Alexandre Dubrac (Yale University, USA)
3:45 pm - 4:20 pmHolger Gerhardt (Vesalius Research Center, KU Leuven, Germany)
"Mechanisms and Mechanics in Vascular Patterning"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrom Sprouts to Established Vessels: Mechanisms of Endothelial Function
Discussion Leaders: Christer Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden) and Mafalda Lopes Da Silva (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom)
7:30 pm - 7:45 pmDionna Kasper (Yale University School of Medicine, USA)
"Mutagenesis of microRNA Genes Uncovers Trait Variance as a Unique Vascular Phenotype that Confers Stress Sensitization"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmJonathan Nelson (Oregon Health and Science University, USA)
"Hypertension-Dependent Reprogramming of the Endothelial Transcriptome"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmTakao Hikita (Max-Planck-Institute for Heart and Lung Research, Germany)
"Antagonism Between PAR-3/aPKC and aPKC/GSK3beta Complexes Controls Endothelial Polarization in the Planar Axis Toward Flow"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMarchand Marion (College de France, France)
"Extracellular Matrix Scaffolding Dictates Endothelial Mechanotransduction and 3D Vascular Morphogenesis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmDavid Wu (University of Chicago, USA)
"Mechanical Regulation of Endothelial Cell Metabolism by HIF-1alpha"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmPengchun Yu (Yale University School of Medicine, USA)
"FGF-Dependent Metabolic Control of Vascular Development"
9:25 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amEndothelial Partners in Vessel Development and Homeostasis / Specialization of Unique Vascular Beds
Discussion Leaders: Timothy Hla (Harvard Medical School, USA), Kristy Red-Horse (Stanford University, USA), Alaina Reagan (University of Oklahoma Health Sciences Center, USA) and Yoshi Odaka (Cincinnati Children's Hospital Medical Center, USA)
9:00 am - 9:15 amAlan Tang (University of Pennsylvania, USA)
"Unexpected Mechanisms of Cerebral Cavernous Malformation"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amJordan Darden (Virginia Tech, USA)
"Loss of Flt-1 Impacts Pericyte Recruitment and Investment During Early Development"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amTejasvi Dudiki (Cleveland Clinic Foundation, USA)
"Kindlin 3 in Microglia Controls Retinal Vascularization"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amAparna Mahadevan (Cornell University, USA)
"The Left-Right PITX2 Pathway Coordinates Gut Morphogenesis with Organ-Specific Arterial and Lymphatic Development"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amTine Wyseure (The Scripps Research Institute, USA)
"Defective TAFI Activation in Hemophilia Exacerbates Vascular Remodeling in Hemophilic Arthropathy"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amMiguel Lopez-Ramirez (University of California, San Diego, USA)
"Thrombospondin1 (TSP1) Replacement Prevents Cerebral Cavernous Malformations"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
A panel of established professionals from academia and industry.
Discussion Leaders: Jennifer Fang (Yale University, USA) and Irinna Papangeli (Yale University, USA)
1:30 pm - 2:30 pmPanel Discussion
"So You Want to Be a Vascular Biologist"
  • Kristy Red-Horse (Stanford University, USA)
  • Holger Gerhardt (Vesalius Research Center, KU Leuven, Germany)
  • Sunday Oladipupo (Lilly Research Laboratories, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL135861-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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