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Cell Polarity Signaling (GRS)
Gordon-Kenan Research Seminar

Cell Polarity in Development and Disease

Dates

June 11-12, 2016

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Sergio Simoes & Lindsey Seldin

Meeting Description

The Gordon Research Seminar (GRS) on Cell Polarity Signaling (June 11-12, 2016) will gather students and postdoctoral fellows to present and discuss their latest cutting-edge findings in this exciting field of research. Cell Polarity – the asymmetric organization of cellular components and structures – plays a critical role in various important aspects of cell biology, including proliferation, morphogenesis and differentiation of unicellular and multicellular organisms. This seminar will provide a great opportunity for career networking and mentoring, with an exciting scientific program that includes interactive sessions on modeling and quantitative analysis of cell polarity, polarity control during morphogenesis and deregulation of polarity in disease.

Related Meeting

This GRS was held in conjunction with the "Cell Polarity Signaling" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Mechanisms of Cell Shape Change In Vivo
Discussion Leader: Elaine Fuchs (The Rockefeller University, USA)
3:45 pm - 4:25 pmBob Goldstein (University of North Carolina at Chapel Hill, USA)
"Mechanisms of Cell Shape Change In Vivo"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMeasuring Cell Polarity – Analytical Imaging Tools and Modelling
Discussion Leader: Daniel Lew (Duke University Medical Center, USA)
7:30 pm - 7:45 pmAaron Mertz (Rockefeller University, USA)
"How Is a Stratified Epithelium Built Mechanically In Vivo?"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmAbhijit Deb Roy (University of Connecticut Health Center, USA)
"An Optogenetic Approach to Delineate Spatial Regulation of Semaphorin-Plexin Signaling in Contact Inhibition of Locomotion"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmFloris Bosveld (Institut Curie, France)
"Spindle Orientation in Epithelial Tissue"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmTeresa Zulueta-Coarasa (University of Toronto, Canada)
"Dynamic, Stochastic Actomyosin Pulses Promote Collective Cell Migration and Rapid Embryonic Wound Repair"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmOlga Loza (Tel Aviv University, Israel)
"A Synthetic Biology Approach for Studying Fat4-Ds1 Planar Cell Polarity Signaling"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAllyson Sgro (Princeton University, USA)
"From Intracellular Signaling to Collective Behavior: Understanding the Dynamical Origins of Collective cAMP Oscillations in Dictyostelium discoideum"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPolarity in Cell Migration and Disease
Discussion Leader: Luke McCaffrey (McGill University, Canada)
9:00 am - 9:15 amDanielle Park (Francis Crick Institute, United Kingdom)
"Extracellular Matrix Anisotropy in Cancer Invasion and Metastasis"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amYuliya Petrova (University of Virginia, USA)
"Roles of E-Cadherin Mutations and Adhesion Activity in Cancer"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMukhtar Ahmed (Vanderbilt University, USA)
"The Par3-Exocyst Interaction Is Central for Mammary Epithelial Cell Survival"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amVanesa Jimenez-Amilburu (Max Planck Institute for Heart and Lung Research, Germany)
"Cardiomyocyte Polarity Dynamics During Heart Trabeculation"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amManuel Hotz (Stanford University, USA)
"Pumilio-Dependent Transcript Asymmetry Drives Polarization of Chemotactic Cells"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amPaulina Mrozowska (Tohoku University, Japan)
"Regulation of Podocalyxin Trafficking by Rab Small GTPases in 2D and 3D Epithelial Cell Cultures"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmPolarity in Morphogenesis and Signal Transduction
Discussion Leader: Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA)
1:30 pm - 1:45 pmAndrea Dimitracopoulos (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom)
"The Role of Mitotic Rounding in Spindle Positioning"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmMitchell Butler (The University of Texas at Austin, USA)
"The Control of Planar Cell Polarity Patterning Dynamics During Vertebrate Development"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmMatias Escobar (University of Pennsylvania, USA)
"Dissecting Microtubule-Actin Crosslinking Factor (Macf1) Function in Establishing Oocyte Polarity and Nuclear Positioning"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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