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Centromere Biology (GRS)
Gordon-Kenan Research Seminar

Building a Bridge from Centromeres to Spindle Microtubules

Dates

July 23-24, 2016

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Steven Friedman & Shannon M. McNulty

Meeting Description

The Gordon Research Seminar on Centromere Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. In addition, a session covering careers in science will provide an opportunity to consider the many paths to success in scientific careers and hear from a diverse panel of scientists.

The focus of this meeting is the mechanisms by which the bridge from centromere to spindle microtubules is built for accurate chromosome segregation through mitosis and meiosis. The meeting will cover the most up to date research in a wide variety of organisms. Topics of interest will include the epigenetic basis of centromere formation and function, the outer components of kinetochore that interact with microtubules, and emerging methods and areas of interest related to these topics.

Related Meeting

This GRS was held in conjunction with the "Centromere Biology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Chromosome-Microtubule Interactions
Discussion Leader: Paul Maddox (University of North Carolina at Chapel Hill, USA)
3:45 pm - 4:15 pmArshad Desai (University of California, San Diego, USA)
"Insights into the Dynamic Evolution of the Kinetochore-Microtubule Interface"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetics of Centromere Function
Discussion Leader: Daniele Fachinetti (Institut Curie, France)
7:30 pm - 7:50 pmAnne Barbosa (University of Nottingham, United Kingdom)
"Using Chromosome Engineering on Unusual Natural Isolate of the Fission Yeast Schizosaccharomyces pombe to Investigate Epigenetic Inheritance of the Kinetochore"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBradley French (Stanford University, USA)
"Dissecting the Role of the Mis18 Complex in the Spatiotemporal Regulation of CENP-A Assembly"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSundaram Kuppu (University of California, Davis, USA)
"Point Mutations in CenH3 Induce Zygotic Incompatibility and Uniparental Inheritance"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmNuno Martins (Harvard Medical School, USA)
"Centromeres and Heterochromatin: A Love-Hate Relationship"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amEmerging Areas in Centromere Research
Discussion Leader: Kerry Bloom (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amKonstanty Cieslinski (European Molecular Biology Laboratory, Germany)
"Structural Studies of the Budding Yeast Kinetochore Using Dual-Color Superresolution Microscopy"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 amDaniel Melters (National Cancer Institute, NIH, USA)
"CENP-C Occupies to a Unique Centormeric Chromatin Domain"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amYuji Tanno (Institute of Molecular and Cellular Biosciences (IMCB), University of Tokyo, Japan)
"Destabilization of the Inner Centromere-Shugoshin Network Causes Chromosomal Instability"
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 amKwaku Opoku (University of Washington, USA)
"Examining the Release of Spindle Assembly Checkpoint Proteins from Single Kinetochores In Vitro"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amFan Yang (Temasek Life Sciences Laboratory, Singapore)
"Functional Analyses of Centromere Proteins CenpA and CenpC in Magnaporthe oryzae"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Navigating Careers in Science
This will be a career panel of accomplished scientists from multiple career trajectories. Please come with your career, and job, related questions.
Discussion Leader: Karen Miga (University of California, Santa Cruz, USA)
1:30 pm - 2:30 pmPanel Discussion
"Navigating Careers in Science"
  • Kerry Bloom (University of North Carolina at Chapel Hill, USA)
  • Patrick Heun (University of Edinburgh, United Kingdom)
  • Rachel O'Neill (University of Connecticut, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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