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DNA Damage, Mutation & Cancer (GRS)
Gordon-Kenan Research Seminar

Genome Instability from Environmental and Inherent Sources of DNA Damage

Dates

March 12-13, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Jane C. Kim

Meeting Description

The inaugural 2016 Gordon Research Seminar on DNA Damage, Mutation and Cancer will be a forum where cutting-edge research on the molecular mechanisms responsible for the recognition, processing, and repair of DNA damage is presented by the graduate students, post-docs, and early career scientists who conduct this exciting research.

The format of this meeting will empower young scientists to present new data and exchange ideas among their peers. A select number of established scientists whose role is to help facilitate discussion will also be in attendance, and a professional development session will focus on equipping attendees to be successful in their future job searches. Young scientists from a broad range of experimental backgrounds and interests are encouraged to present their unpublished work on environmental and endogenous DNA damage, mutagenesis, DNA repair, and their relation to the development, progression, and treatment of cancer.

Related Meeting

This GRS was held in conjunction with the "DNA Damage, Mutation & Cancer" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Curiosity, Questions, and Discovery
Discussion Leaders: Somaira Nowsheen (Mayo Clinic, USA) and Yinbo Zhang (University of Nebraska Medical Center, USA)
3:45 pm - 4:15 pmJohannes Walter (Harvard Medical School, USA)
"At the Intersection of Vertebrate DNA Replication and Repair"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDiverse Strategies for Investigating Fidelity of DNA Repair / Regulation of the Cellular Response to DNA Damage
Discussion Leaders: Melike Caglayan (National Institute of Environmental Health Sciences, NIH, USA) and Muthiah Bose (University of Oulu, Finland)
7:30 pm - 7:45 pmEric Josephs (Duke University, USA)
"Structure and Mechanics of Repair Complexes During Methyl-Directed DNA Mismatch Repair"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmNicole Williams (University of California, Riverside, USA)
"The Roles of DNA Polymerases Eta, Iota, Kappa and Zeta in the Bypass of O2- and O4-Alkylthymidine Lesions In Vitro and in Human Cells"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmTaty Taty Gemael Cedrick (LBCMCP, Université Paul Sabatier, France)
"Role of Chromatin Remodeling Enzymes in the Repair of DNA Double Strand Breaks and Genetic Instability"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmKatherine Choe (Pennsylvania State University College of Medicine, USA)
"HUWE1 Is a Novel PCNA-Interacting Protein that Promotes the Repair of Broken Replication Forks"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJudit Jimenez Sainz (Yale School of Medicine, USA)
"The Two BRC Repeat Modules in BRCA2 Mediate Distinct Binding Modes for RAD51 and Differential Sensitivity to DNA Damage"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amRNA-DNA Interplay in Genome Instability / Fragile and Repetitive DNA Sequences
Discussion Leaders: John Pryor (University of North Carolina, USA) and Katharina Bilotti (Brown University, USA)
9:00 am - 9:15 amAlessandra Brambati (Institute of Molecular Genetics (IGM), National Research Council, Italy)
"Mechanisms that Rescue Replication Forks Arrested by Transcription"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amKate Reid-Bayliss (University of Washington, USA)
"Detection of RNA Mutations Due to Transcriptional Infidelity by Next-Generation Sequencing"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amJinchuan Hu (University of North Carolina School of Medicine, USA)
"Mapping UV and Cisplatin Induced DNA Damage and Repair at Nucleotide Resolution in Human Cells"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amRyan Barnes (Pennsylvania State University College of Medicine, USA)
"Human DNA Polymerase Eta Mitigates Replication Stress and Preserves Genome Stability by Replicating Common Fragile Sites"
10:30 am - 10:40 amDiscussion
10:40 am - 10:55 amXiaofeng Su (Tufts University, USA)
"Cytosine Deamination Mediates R-Loop Dependent CAG Repeat Fragility and Instability"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Strategies for Successful Funding
Discussion Leader: Alexander Neil (Tufts Unversity, USA)
1:30 pm - 2:30 pmPanel Discussion
"Strategies for Successful Funding"
  • Anna Malkova (University of Iowa, USA)
  • Mitch McVey (Tufts University, USA)
  • Wendy Lam (Franklin Templeton Investments, USA)
  • Eric Olmon (Brown University, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13CA203164-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health & Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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