2016 Gordon Research Seminar on DNA Damage, Mutation and Cancer will be a
forum where cutting-edge research on the molecular mechanisms responsible for
the recognition, processing, and repair of DNA damage is presented by the
graduate students, post-docs, and early career scientists who conduct this
The format of
this meeting will empower young scientists to present new data and exchange ideas
among their peers. A select number of established scientists whose role is to
help facilitate discussion will also be in attendance, and a professional
development session will focus on equipping attendees to be successful in their
future job searches. Young scientists from a broad range of experimental
backgrounds and interests are encouraged to present their unpublished work on
environmental and endogenous DNA damage, mutagenesis, DNA repair, and their
relation to the development, progression, and treatment of cancer.
This GRS was held in conjunction with the "DNA Damage, Mutation & Cancer" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
Seed funding for this new Gordon Research Seminar has been provided by the Kenan Institute for Engineering, Technology and Science at North Carolina State University.
Final Meeting Program
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: Curiosity, Questions, and Discovery|
|Discussion Leaders: Somaira Nowsheen (Mayo Clinic, USA) and Yinbo Zhang (University of Nebraska Medical Center, USA)|
|3:45 pm - 4:15 pm||Johannes Walter (Harvard Medical School, USA)|
"At the Intersection of Vertebrate DNA Replication and Repair"
|4:15 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Diverse Strategies for Investigating Fidelity of DNA Repair / Regulation of the Cellular Response to DNA Damage|
|Discussion Leaders: Melike Caglayan (National Institute of Environmental Health Sciences, NIH, USA) and Muthiah Bose (University of Oulu, Finland)|
|7:30 pm - 7:45 pm||Eric Josephs (Duke University, USA)|
"Structure and Mechanics of Repair Complexes During Methyl-Directed DNA Mismatch Repair"
|7:45 pm - 7:55 pm||Discussion|
|7:55 pm - 8:10 pm||Nicole Williams (University of California, Riverside, USA)|
"The Roles of DNA Polymerases Eta, Iota, Kappa and Zeta in the Bypass of O2- and O4-Alkylthymidine Lesions In Vitro and in Human Cells"
|8:10 pm - 8:20 pm||Discussion|
|8:20 pm - 8:35 pm||Taty Taty Gemael Cedrick (LBCMCP, Université Paul Sabatier, France)|
"Role of Chromatin Remodeling Enzymes in the Repair of DNA Double Strand Breaks and Genetic Instability"
|8:35 pm - 8:45 pm||Discussion|
|8:45 pm - 9:00 pm||Katherine Choe (Pennsylvania State University College of Medicine, USA)|
"HUWE1 Is a Novel PCNA-Interacting Protein that Promotes the Repair of Broken Replication Forks"
|9:00 pm - 9:10 pm||Discussion|
|9:10 pm - 9:25 pm||Judit Jimenez Sainz (Yale School of Medicine, USA)|
"The Two BRC Repeat Modules in BRCA2 Mediate Distinct Binding Modes for RAD51 and Differential Sensitivity to DNA Damage"
|9:25 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||RNA-DNA Interplay in Genome Instability /
Fragile and Repetitive DNA Sequences|
|Discussion Leaders: John Pryor (University of North Carolina, USA) and Katharina Bilotti (Brown University, USA)|
|9:00 am - 9:15 am||Alessandra Brambati (Institute of Molecular Genetics (IGM), National Research Council, Italy)|
"Mechanisms that Rescue Replication Forks Arrested by Transcription"
|9:15 am - 9:25 am||Discussion|
|9:25 am - 9:40 am||Kate Reid-Bayliss (University of Washington, USA)|
"Detection of RNA Mutations Due to Transcriptional Infidelity by Next-Generation Sequencing"
|9:40 am - 9:50 am||Discussion|
|9:50 am - 10:05 am||Jinchuan Hu (University of North Carolina School of Medicine, USA)|
"Mapping UV and Cisplatin Induced DNA Damage and Repair at Nucleotide Resolution in Human Cells"
|10:05 am - 10:15 am||Discussion|
|10:15 am - 10:30 am||Ryan Barnes (Pennsylvania State University College of Medicine, USA)|
"Human DNA Polymerase Eta Mitigates Replication Stress and Preserves Genome Stability by Replicating Common Fragile Sites"
|10:30 am - 10:40 am||Discussion|
|10:40 am - 10:55 am||Xiaofeng Su (Tufts University, USA)|
"Cytosine Deamination Mediates R-Loop Dependent CAG Repeat Fragility and Instability"
|10:55 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: Strategies for Successful Funding|
|Discussion Leader: Alexander Neil (Tufts Unversity, USA)|
|1:30 pm - 2:30 pm||Panel Discussion|
|"Strategies for Successful Funding"|
- Anna Malkova (University of Iowa, USA)
- Mitch McVey (Tufts University, USA)
- Wendy Lam (Franklin Templeton Investments, USA)
- Eric Olmon (Brown University, USA)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Funding for this conference was made possible (in part) by 1R13CA203164-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health & Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.