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DNA Topoisomerases in Biology & Medicine (GRS)
Gordon Research Seminar

New Roles, New Drugs, and New Interactions for DNA Topoisomerases

Dates

August 6-7, 2016

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chairs:
Natassja G. Bush & Selma M. Cuya

Meeting Description

The Gordon Research Seminar on DNA Topoisomerases in Biology and Medicine is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of the 2016 GRS will be to highlight the future of DNA topoisomerase research. It will address the new roles and interactions that DNA topoisomerases are being shown to have, as well as research on novel inhibitors. We hope to provide an opportunity to see what our own futures in topoisomerase research may be, as well as, how to go about establishing a career in the topoisomerase field.

Related Meeting

This GRS was held in conjunction with the "DNA Topoisomerases in Biology & Medicine" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Targeting Type II Topoisomerases
Discussion Leader: Anthony Maxwell (John Innes Centre, United Kingdom)
3:45 pm - 4:15 pmKatie Aldred (University of Evansville, USA)
"E. coli Gyrase: Interactions with Quinolones"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCellular Roles of Topoisomerases and Their Interactions
Discussion Leader: Robert Van Waardenburg (University of Alabama at Birmingham, USA)
7:30 pm - 7:50 pmSarmistha Guha (Indian Institute of Science, India)
"Consequences of Perturbing DNA Gyrase Expression: Effect on Mycobacterial Growth, Physiology and Gene Regulation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKevin Lang (University of Washington, USA)
"Type II Topoisomerases Resolve Replication-Transcription Conflicts"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJenna Lieberman (Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Spain)
"Regulation of TDP2 Function by SUMO Interactions"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDavid Ontoso (Memorial Sloan Kettering Cancer Center, USA)
"Repair of Topoisomerase II-Induced DNA Double-Strand Breaks"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amTopoisomerase Structure, Function and Drug Interactions
Discussion Leader: Roketa Sloan (St. Jude Children's Research Hospital, USA)
9:00 am - 9:20 amRachel Ashley (Vanderbilt University, USA)
"Twists and Turns: Recognition of DNA Topology by Bacterial Type II Topoisomerases"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amThomas Germe (John Innes Centre, United Kingdom)
"New Allosteric Inhibitors of DNA Gyrase Reveal a Stepwise Re-Ligation Mechanism"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amElizabeth Gibson (Vanderbilt University, USA)
"'Mycobacterium Gyrase Inhibitors' (MGIs): A Novel Class of Gyrase Poisons"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amLorena Infante (Vanderbilt University, USA)
"'Oligonucleotide-Topoisomerase Inhibitors' Enhance Site-Specific DNA Cleavage Mediated by Human Type II Topoisomerases"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
This Mentorship session will be a career question and answer session with panelists from industry and academia.
Discussion Leader: Mary-Ann Bjornsti (University of Alabama at Birmingham, USA)
1:30 pm - 1:35 pmIntroduction by Discussion Leader
1:35 pm - 2:25 pmPanel Discussion
"Our Future in Topoisomerase Research"
  • Alison Howells (Inspiralis Limited, United Kingdom)
  • Yves Pommier (National Cancer Institute, NIH, USA)
  • Lynn Zechiedrich (Baylor College of Medicine, USA)
  • Katie Aldred (University of Evansville, USA)
  • Anthony Maxwell (John Innes Centre, United Kingdom)
  • Robert Van Waardenburg (University of Alabama at Birmingham, USA)
2:25 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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