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Drug Safety (GRS)
Gordon-Kenan Research Seminar

Drug Safety Assessment in the 21st Century: From In Silico and Tissue Chips to Patient Tailoring

Dates

June 25-26, 2016

Location

Stonehill College
Easton, MA

Organizers

Chairs:
Peter Loskill & Rowena R. Sison-Young

Meeting Description

The Gordon Research Seminar on Drug Safety is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is the latest development and application of innovative methodologies for pharmaceutical risk assessment. It will cover multiple topics from the drug discovery and development process and feature the three sessions: "Pharmacogenomics and patient tailored drug safety", "In vitro tissue model systems to predict organ toxicity", and "Computational drug safety: From in silico prediction of drug safety to big data in clinical trials". The seminar will conclude with a career panel with established and highly respected mentors from academia, industry, and governmental institutions, which will provide an invaluable opportunity for young researchers to ask questions and gain insight into career trajectories in both research and industry.

Related Meeting

This GRS was held in conjunction with the "Drug Safety" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Future Challenges of Drug Safety Research
Discussion Leader: Peter Loskill (Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany)
3:45 pm - 4:25 pmTeresa Woodruff (Northwestern University, USA)
"Building the Tools that Solve Emerging Problems that Create New Fields: It's No Longer Bench to Paper to Grant and Back!"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIn Vitro Tissue Model Systems for the Prediction of Toxicity
Discussion Leader: Stephanie Dauth (Harvard University, USA)
7:30 pm - 7:45 pmMarie-Elena Brett (University of Minnesota, USA)
"High Throughput 3D Cell Culture Platform for Drug Development"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmYimu Zhao (University of Toronto, Canada)
"Biowire II: Drug Testing Platform Using Matured Human Engineered Cardiac Tissue"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmNathaniel Huebsch (Gladstone Institute of Cardiovascular Disease, UCSF, USA)
"Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmJohan Lind (Harvard University, USA)
"Higher Throughput Instrumented Cardiac Organs-on-Chip Devices"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMarko Groeger (Jena University Hospital, Germany)
"Microfluidically Supported Organoids for Modelling Systemic Inflammation"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmIlka Maschmeyer (TissUse, Germany)
"Multi-Organ-Chip Developments: Towards a Paradigm Shift in Drug Development"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amComputational Drug Safety / Pharmacogenomics and Patient Tailored Drug Safety
Discussion Leaders: Troy Hawkins (Eli Lilly and Company / Elanco Animal Health, USA) and Katie White (Vanderbilt University, USA)
9:00 am - 9:15 amEric Watt (U.S. Environmental Protection Agency, USA)
"Uncertainty Quantification in High Throughput Screening: Applications to Models of Endocrine Disruption, Cytotoxicity, and Zebrafish Development"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amTal Lorberbaum (Columbia University, USA)
"Discovering New Drug-Drug Interactions Using Data Science and Systems Pharmacology: Applications to Drug-Induced Long QT Syndrome"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amTakaya Moriyama (St. Jude Children's Research Hospital, USA)
"NUDT15 Polymorphisms and Thiopurine Treatment Individualization in Children with Acute Lymphoblastic Leukemia (ALL)"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amNatalie Holman (Hamner-UNC Institute for Drug Safety Sciences, USA)
"Hepatocyte-Derived Exosomes: Early Mediators of Drug-Induced Liver Injury?"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amJulia Tobacyk (University of Arkansas for Medical Sciences, USA)
"Population Variability in Cisplatin-Induced Kidney Injury Outcomes Are Modeled Using Diversity Outbred Mice"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amLaura Wiley (Vanderbilt University, USA)
"Strategies for Equitable Pharmacogenomic-Guided Warfarin Dosing Among European and African American Individuals in a Clinical Population"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Rowena Sison-Young (University of Liverpool, United Kingdom)
1:30 pm - 2:30 pmPanel Discussion
"Getting the Foot in the Door: First Steps on the Way to a Job in Academia, Industry or Governmental Institutions"
  • Robert Chapin (Pfizer Global Research and Development, USA)
  • Myrtle Davis (National Cancer Institute, NIH, USA)
  • Kristin Fabre (AstraZeneca, USA)
  • Gunaretnam Rajagopal (Janssen R&D, USA)
  • Teresa Woodruff (Northwestern University, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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