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Genomic Instability (GRS)
Gordon Research Seminar

Molecular Interplay of Chromatin Organization, Replication and Repair

Dates

July 23-24, 2016

Location

The Hong Kong University of Science and Technology
Hong Kong, China

Organizers

Chairs:
Darshil Patel & Mrinal Srivastava

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Meeting Description

The Gordon Research Seminar on Genomic Instability is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will focus on understanding how the complex interplay between chromatin organization, DNA replication and DNA repair is orchestrated for the maintenance of genomic integrity. Along with scientific talks and posters from graduate students and post-docs, the GRS will also include a keynote research presentation by Dr. Thanos Halazonetis and a career panel discussion with scientists from both industry and academia.

Related Meeting

This GRS was held in conjunction with the "Genomic Instability" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Exploring the Role of DNA Replication and Repair in Cancer
Discussion Leaders: Darshil Patel (Cornell University, USA) and Mrinal Srivastava (University of Texas MD Anderson Cancer Center, USA)
3:45 pm - 4:20 pmThanos Halazonetis (University of Geneva, Switzerland)
"DNA Replication Stress in Cancer and Relevant Repair Pathways"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEmerging Trends in DNA Repair
Discussion Leader: Shrestha Ghosh (The University of Hong Kong, Hong Kong SAR China)
7:30 pm - 7:45 pmWai Chung (Justin) Leung (University of Texas at Austin, USA)
"ZMYM3/ZNF261 Promotes Homologous Recombination via BRCA1-A Complex Axis"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmLiwei An (The University of Hong Kong, Hong Kong SAR China)
"USP7 Enforces RNF169-Dependent DNA Double-Strand Break Responses"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmCarl Schiltz (Cornell University, USA)
"Structural and Functional Insights into the OLD Family Endonucleases"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmBrittany Haynes (Barbara Ann Karmanos Cancer Institute, USA)
"Targeting Rad6 Sensitizes Triple Negative Breast Cancer Cells to Cisplatin by Attenuating Translesion Synthesis and Fanconi Anemia Network Mediated Repair"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJirawas Sornkom (Peter MacCallum Cancer Centre, Australia)
"Dual Targeting of RNA Pol I and BET Proteins at the rDNA as a Highly Effective Therapeutic Strategy for the Treatment of Acute Myeloid Leukaemia"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmHui Li (Shanghai Children's Medical Center, China)
"Negative Feedback-Defective PRPS1 Mutants Drive Thiopurine Resistance in Relapsed Childhood ALL"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amChromatin Dynamics and DNA Replication
Discussion Leader: Naveed Ishaque (German Cancer Research Institute, Germany)
9:00 am - 9:15 amDeepti Sharma (Nanyang Technological University, Singapore)
"PARP1-Nucleosome Binding Kinetics Are Influenced by the Histone Protein Composition"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amDongsung Kim (Cornell University, USA)
"Methyltransferase-Like METTL13 Associates with Claspin and Is Required for Proper Genome Replication and Chromatin Dynamics"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJigar Bandaria (University of California, Berkeley, USA)
"Super-Resolution Imaging Reveals Shelterin Mediated Compaction of Telomeric Chromatin Protects Chromosome Ends"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amGustavo Santoyo (Universidad Michoacana de San Nicolás de Hidalgo, Mexico)
"Spo11 Is Required for Elevated Mutation Rate During Meiosis in Saccharomyces cerevisiae"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amLana Talmane (The University of Edinburgh, United Kingdom)
"The Landscape of Replication-Associated Mutations in Human and Mouse Germlines"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amGiulia Saredi (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)
"H4 K20me0 Marks Post-Replicative Chromatin and Recruits the TONSL-MMS22L DNA Repair Complex"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel Discussion
Discussion Leaders: Catalina Pereira (Cornell University, USA) and Jessica Woodward (University of Edinburgh, United Kingdom)
1:30 pm - 2:30 pmPanel Discussion
"Exploring Your Options: Personal-Professional Life Balance in Academia and Industry"
  • Anindya Dutta (University of Virginia, USA)
  • Eric Lightcap (Takeda Pharmaceuticals International, USA)
  • Thanos Halazonetis (University of Geneva, Switzerland)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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