Gordon Research Conferences
Meeting Details

Ligand Recognition & Molecular Gating (GRS)
Gordon-Kenan Research Seminar

Molecular Basis of Ligand Recognition and Gating in Transmembrane Signaling and Transport


January 30-31, 2016


Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy


Cristina Paulino & Mingfeng Tsai

Meeting Description

The goal of the first GRS is to share the latest knowledge on the mechanism of function of three important classes of membrane proteins: receptors, transporters, and ion channels. It will provide a comprehensive understanding on how key questions on mechanistic aspects of gating, activation, and ensuing conformational changes during transport are approached.

The GRS follows the rule "by students, for students" and provides a unique, stimulating platform for early-career scientists from different research and geographical areas to present their work, exchange ideas, and to establish long-term collaborations. Graduate students and post-docs will benefit from the talks and discussions and increase their confidence to participate actively in the subsequent GRC. A mentoring session will offer training and career guidance for young scientists.

Related Meeting

This GRS was held in conjunction with the "Ligand Recognition & Molecular Gating" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Where Do You Belong?
Discussion Leader: Crina Nimigean (Weill Cornell Medical College, USA)
3:15 pm - 3:20 pmIntroduction by Discussion Leader
3:20 pm - 3:50 pmPoul Nissen (Aarhus University, Denmark)
"How Do Primary and Secondary Transporters Switch Side?"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmGlutamate Receptors
Discussion Leaders: Marina Diskowski (Goethe University Frankfurt, Germany) and Manuel Arcangeletti (International School for Advanced Studies (SISSA), Italy)
5:30 pm - 5:50 pmJoel Meyerson (Brandeis University, USA)
"Structural Mechanism of Glutamate Receptor Activation and Desensitization"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmJelena Baranovic (NeuroCure, Charité Universitätsmedizin, Germany)
"Dynamics of the AMPA Receptor Ligand Binding Domain Layer"
6:20 pm - 6:30 pmDiscussion
Elucidating the Mechanism of Membrane Transporters
6:30 pm - 6:45 pmM. Gregor Madej (University of California, Los Angeles, USA)
"The pK-Switch Mechanism in MFS Sugar/H+ Symporters"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmRyan Henderson (University of Groningen, The Netherlands)
"Proton Coupling by the Maltose Transporter of Saccharomyces cerevisiae"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmSalome Veshaguri (University of Copenhagen, Denmark)
"A Novel Method to Study Transport at the Single Molecule Level: New Insights on Transporter Function and Regulation"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amFlipping and Gating
Discussion Leaders: Jennifer Booker (Birkbeck University of London, United Kingdom) and Andres Jara-Oseguera (National Institute of Neurological Disorders and Stroke, NIH, USA)
9:00 am - 9:20 amCamilo Perez (ETH Zürich, Switzerland)
"Structure and Mechanism of an ATP-Driven Lipid-Linked Oligosaccharide Flippase"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amOliver Clarke (Columbia University, USA)
"Structural Insights into RyR1 Activation"
9:50 am - 10:00 amDiscussion
Gating and Activation of the TRPV1 and CorA Ion Channel
10:00 am - 10:15 amClaudio Anselmi (National Heart, Lung, and Blood Institute, NIH, USA)
"Mechanism of Activation of the TRPV1 Channel by a Double-Knot Tarantula Toxin"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amFan Yang (University of California, Davis, USA)
"Structural Mechanism Underlying Capsaicin Binding and Activation of the TRPV1 Ion Channel"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amDoreen Matthies (National Cancer Institute, NIH, USA)
"Single-Particle Cryo-EM Studies of a 200 kDa Magnesium Ion Channel Reveal Large Structural Changes Upon Gating"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Cristina Paulino (University of Zurich, Switzerland)
1:30 pm - 2:15 pmPanel Discussion
"Which Career Path Do You Choose?"
  • Rebecca Kirk (Nature Publishing Group, United Kingdom)
  • Poul Nissen (Aarhus University, Denmark)
  • Shin Numao (Novartis Pharma AG, Switzerland)
2:15 pm - 2:30 pmGeneral Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS095582. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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