Gordon Research Conferences
Meeting Details

Mechanisms of Epilepsy & Neuronal Synchronization (GRS)
Gordon Research Seminar

Dynamic Epilepsy Circuits and Their Modulation


August 20-21, 2016


PGA Catalunya Business and Convention Centre
Girona, Spain


Omar J. Ahmed & Laura A. Ewell

Meeting Description

The Gordon Research Seminar on Mechanisms of Epilepsy and Neuronal Synchronization is a unique forum for graduate/medical students, post-docs, residents, fellows and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to build towards a detailed mechanistic understanding of the circuits, cells, ion channels and genes that regulate epileptic brain states. Topics covered will include the cortical and subcortical circuitry underlying different kinds of seizures, neuron-glia communication, neuromodulatory systems, and novel therapeutic strategies.

Related Meeting

This GRS was held in conjunction with the "Mechanisms of Epilepsy & Neuronal Synchronization" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Translational Research in Epilepsy
Discussion Leader: Ivan Soltesz (Stanford University, USA)
3:15 pm - 3:50 pmDaniel Lowenstein (University of California, San Francisco, USA)
"The Coin of the Realm"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmNeural Circuits and Networks in the Epilepsies
Discussion Leader: John Huguenard (Stanford University, USA)
5:30 pm - 5:45 pmStefanie Makinson (Gladstone Institutes, University of California, San Francisco, USA)
"Optogenetic Targeting of the Thalamus for Bidirectional Control of Seizures in Dravet Syndrome"
5:45 pm - 5:55 pmDiscussion
5:55 pm - 6:10 pmJacob Hull (University of Michigan, USA)
"Pyramidal Neuron Subpopulation Specific Increase in Excitability with Reduced Function and Expression of Voltage Gated Sodium Channels in the Scn1b Null Mouse Model of Dravet Syndrome"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:35 pmBethany Hosford (Cincinnati Children's Hospital Medical Center, USA)
"Ablation of Adult-Generated, Ectopic Dentate Granule Cells Can Decrease Seizure Severity"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:00 pmXi Du (University of Michigan, USA)
"Retrograde Trans-Synaptic Tracing Reveals Novel as Well as Altered Presynaptic Inputs onto Adult-Born Dentate Granule Cells in Experimental Temporal Lobe Epilepsy"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmAnthony Umpierre (University of Utah, USA)
"Alterations in Astrocyte Calcium Activity and Signaling Pathways During Epileptogenesis"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amRegulation and Control of Excitability
Discussion Leader: Lori Isom (University of Michigan, USA)
9:00 am - 9:15 amHannah Alfonsa (University of Oxford, United Kingdom)
"Cl-Out: A Novel Cooperative Optogenetic Tool for Extruding Chloride from Neurons"
9:15 am - 9:25 amDiscussion
9:25 am - 9:40 amMatthew Kelley (Tufts University, USA)
"Deficits in Neuronal Chloride Transport Tune Seizure Susceptibility and Severity"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amGiordano Lippi (University of California, San Diego, USA)
"MicroRNA-101 Constrains the Development of Neural Networks to Balance Excitation"
10:05 am - 10:15 amDiscussion
10:15 am - 10:30 amLauren Lau (Tufts University, USA)
"Targeting a2d-1 Prevents Pathological Synaptogenesis, Cell Death and Epileptogenic Circuit Reorganization Following Neonatal Cortical Insult"
10:30 am - 10:40 amDiscussion
10:40 am - 10:55 amAngel Lopez (Baylor College of Medicine, USA)
"Ankyrin-G Isoform Imbalance and Interneuronopathy Link Epilepsy and Bipolar Disorder"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Careers and Funding in Epilepsy Research
Discussion Leaders: Omar Ahmed (University of Michigan, USA) and Laura Ewell (University of California, San Diego, USA)
1:30 pm - 2:30 pmPanel Discussion
"Careers and Funding in Epilepsy Research"
  • Daniel Lowenstein (University of California, San Francisco, USA)
  • Julie Milder (Citizens United for Research in Epilepsy (CURE), USA)
  • Vicky Whittemore (National Institute of Neurological Disorders and Stroke, NIH, USA)
  • Manisha Patel (University of Colorado Anschutz Medical Campus, USA)
  • Amy Brooks-Kayal (Children's Hospital Colorado, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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