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Mutagenesis (GRS)
Gordon-Kenan Research Seminar

Mechanisms of Mutagenesis and Genome Alterations

Dates

June 4-5, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chair:
Aishwarya Prakash

Meeting Description

The Gordon Research Conference on Mutagenesis is launching an associated Gordon Research Seminar for the first time. This unique symposium is an exemplary opportunity for graduate students, post-docs, and beginning scientists with comparable levels of experience and education to present their ongoing and new research.

The focus of this meeting is to bring together young scientists prior to the main conference thereby providing them an opportunity to exchange ideas, future goals, and career paths. The scientific content/talks will be selected from submitted abstracts. Discussion leaders will also be selected from the applicant pool. All attendees are encouraged to present posters of their ongoing, current, and unpublished data. A portion of the GRS will be dedicated to a mentorship component where a career panel comprising scientists from different backgrounds including academic professors, members from funding agencies, and industry will be invited to share their journey and insight into career development.

Related Meeting

This GRS was held in conjunction with the "Mutagenesis" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Studies of Leading and Lagging Strand DNA Replication Fidelity
Discussion Leader: Aishwarya Prakash (The University of South Alabama, USA)
3:15 pm - 3:55 pmThomas Kunkel (National Institute of Environmental Health Sciences, NIH, USA)
"Studies of Leading and Lagging Strand DNA Replication Fidelity"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmThe Interface Between Replication and Repair
Discussion Leader: Michelle Scotland (University at Buffalo, USA)
5:30 pm - 5:45 pmDavid Gallo (University of Toronto, Canada)
"The Roles and Regulation of Rad5, Mgs1 and Pso2 at Stressed DNA Replication Forks in S. cerevisiae"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmNorma Keogh (Centre for Chromosome Biology, National University of Ireland Galway, Ireland)
"DNA Mismatch Repair Complex MutSβ and Trinucleotide Repeat Expansions"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmKelsey Temprine (Memorial Sloan Kettering Cancer Center, USA)
"Evolvability in Melanoma Mediated by Pol?"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmLuis Cortez (Washington State University, USA)
"APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template During DNA Replication"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmSupawat Thongthip (The Rockefeller University, USA)
"Fan1 Deficiency Results in DNA Interstrand Crosslink Repair Defects, Enhanced Tissue Karyomegaly, and Organ Dysfunction"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmGregory Williams (University at Buffalo, USA)
"The Role of Mismatch Repair (MMR) Factors in Trinucleotide Repeat Expansion (TNR) Disorders"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMutagenesis, Enzyme Function, and Disease
Discussion Leader: Kelsey Temprine (Memorial Sloan Kettering Cancer Center, USA)
9:00 am - 9:15 amBogdan Fedeles (Massachusetts Institute of Technology, USA)
"The Mutagenic Base 5-Aza-5,6-Dihydrocytosine, Generated by Synthetic, Antiviral Nucleosides, Is Efficiently Repaired in Double Stranded DNA by the NTH Glycosylase"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amMartin Reijns (MRC Human Genetics Unit, The University of Edinburgh, United Kingdom)
"The Mutational Cost of Chromatin and Regulatory Protein Binding"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMichelle Scotland (University at Buffalo, USA)
"Deciphering the Mechanisms of DNA Polymerase Switching in E. coli"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amNicole Antczak (Northeastern University, USA)
"Active Site Loops of Y-Family DNA Polymerases Human Pol Kappa and E. coli DinB Contribute to Their Specificity and Activity"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amZubaidah Ramdzan (Goodman Cancer Centre, McGill University, Canada)
"CUT Domains Stimulate APE1 Activity and Confer Resistance to Treatments"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amFaye-Marie Vassel (Massachusetts Institute of Technology, USA)
"Unmasking the Many Faces of Rev7/Mad2L2: A Multitasking Translesion Synthesis Protein Involved in Modulating Chemotherapeutic Efficacy and Beyond"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: What's Next? Finding Your Niche
Discussion Leader: Gregory Williams (University at Buffalo, USA)
1:30 pm - 2:30 pmPanel Discussion
"What's Next? Finding Your Niche"
  • Thomas Kunkel (National Institute of Environmental Health Sciences, NIH, USA)
  • Julian Sale (MRC Laboratory of Molecular Biology, United Kingdom)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13ES024658-01 from the National Institute of Environmental Health Sciences and the National Cancer Institute (NCI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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