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Muscle & Molecular Motors
Gordon Research Conference

Motor Mechanisms from Single Molecules to Cellular Function
Note: This conference is currently known as "Cytoskeletal Motors".

Dates

July 17-22, 2016

Location

Mount Snow
West Dover, VT

Organizers

Chair:
Kathleen M. Trybus

Vice Chair:
Samara L. Reck-Peterson

Meeting Description

The 2016 Gordon Research Conference on Muscle and Molecular Motors is one of the leading meetings devoted to understanding the mechanisms by which the diverse molecular motors myosin, kinesin and dynein produce motion and force on their respective tracks (actin or microtubules). A full understanding of normal motor function is required to dissect how their behavior has gone awry in disease processes. The meeting will span a range of techniques by which these processes are investigated: from in vitro approaches that are becoming increasingly more sophisticated with regard to complex reconstitutions, to biophysical and cell biological investigations of motor function in a cellular environment. Improvements in imaging both at the light and electron microscopy levels, and advances in single molecule techniques using reconstituted systems, allow a more detailed assessment of motor function than ever before. Biological questions of interest include motor-driven intracellular transport and trafficking, motors functioning in complex assemblies (muscle, mitotic spindles, cilia), and dynamics of the cytoskeletal tracks these motors engage with.

The 2016 meeting brings together outstanding investigators in biophysics, structural biology, and cell biology. Invited speakers will focus on unpublished work at the forefront of their fields, with many talks emphasizing multi-disciplinary approaches. The organizers are committed to including both established experts as well as more junior researchers that bring fresh new approaches and viewpoints to the field. Platform sessions will include presentations chosen from the abstracts to include the most up-to-date science in the field, and to further encourage the active participation of junior scientists. There will be a strong emphasis on lively discussion following each talk, with an emphasis on questions from students and postdocs. The poster sessions and ample free time provide an atmosphere that favors informal scientific exchanges, fostering the development of new ideas and collaborations.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Motor Structure to Cellular Function
Discussion Leader: Samara Reck-Peterson (University of California, San Diego, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:20 pmAndrew Carter (University of Cambridge, United Kingdom)
"Cryo-EM Reveals How Dynein Binds Dynactin and Cargos"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 8:40 pmIntroduction by Discussion Leader
8:40 pm - 9:15 pmAnna Akhmanova (Utrecht University, The Netherlands)
"Systematic Use of Genetic Knockouts to Investigate Microtubule Organization and Vesicle Transport in Mammalian Cells"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSeeing Is Believing: Structure Informs Mechanism
Discussion Leader: Trina Schroer (Johns Hopkins University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:20 amTrina Schroer (Johns Hopkins University, USA)
"Interactions of Dynein and Dynactin with Coupling Scaffolds"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndres Leschziner (University of California, San Diego, USA)
"The Mechanism of Dynein Regulation by Lis1"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amSelected from Poster Abstracts: Daifei Liu (Yale University, USA)
"Strain Between Leading and Trailing Heads of a Stepping Kinesin Dimer Visualized in 3D by Cryo-EM"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amSelected from Poster Abstracts: Joseph Muretta (University of Minnesota, USA)
"The Structural Kinetics of Switch-1 and the Neck Linker Explain the Functions of Kinesin-1 and Eg5"
10:55 am - 11:00 amDiscussion
11:00 am - 11:20 amAnne Houdusse (Institut Curie / CNRS, France)
"New Insights for the Powerstroke of Myosin Motors"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Pinar Gurel (National Heart, Lung, and Blood Institute, NIH, USA)
"High-Resolution Structural Insight into the Myosin VI-F-Actin Interface"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Yuichiro Maeda (Nagoya University, Japan)
"Crystal Structure of Actin 4-mer in Complex with 2 Fragmin Molecules and the Mechanism of Actin Filament Assembly"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmDonald Winkelmann (Robert Wood Johnson Medical School, Rutgers University, USA)
"Allosteric Control of Cardiac Myosin via Drug Binding in the Coupling Region"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHow Cytoskeletal Elements Generate Force and Motion
Discussion Leader: William Hancock (Pennsylvania State University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:50 pmWilliam Hancock (Pennsylvania State University, USA)
"Tracking the Structural Kinetics of the Kinesin-1 Mechanochemical Cycle by iSCAT Microscopy"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmSelected from Poster Abstracts: Lisa Lippert (University of Pennsylvania, USA)
"Combined PolTIRF and Sub-Pixel Particle Tracking of Cytoplasmic Dynein Suggests a Winch-Like Stepping Mechanism"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmMichael Ostap (University of Pennsylvania School of Medicine, USA)
"Exploring the Force Sensitivities of Myosin Isoforms"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmLee Sweeney (University of Florida, USA)
"The Myosin X Lever Arm Is Designed for Stepping on Actin Bundles"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: James Sellers (National Heart, Lung, and Blood Institute, NIH, USA)
"Mechanics and Dynamics of Single Non-Muscle Myosin-2 Filaments"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmDynamics of Actin and Microtubules
Discussion Leader: Enrique De La Cruz (Yale University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:20 amEnrique De La Cruz (Yale University, USA)
"Actin Filament Fragmentation by Regulatory Severing Proteins"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDavid Kovar (University of Chicago, USA)
"Investigating Actin Filament Dynamics One Molecule at a Time"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amSelected from Poster Abstracts: Silvia Jansen (Brandeis University, USA)
"Diverse Roles of Tropomyosin Isoforms in Controlling Actin Filament Dynamics"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amSelected from Poster Abstracts: Mikael Kerleau-Chretien (Institut Jacques Monod / CNRS, France)
"Modulating Formin Activity with Force"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Manmeet Raval (Pennsylvania State University College of Medicine, USA)
"Investigating the Role of Myosin IIIa Motor and Tail Domain in Regulating the Formation and Elongation of Actin Protrusions"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amSabine Petry (Princeton University, USA)
"Molecular Insights into the Activation of Microtubule Nucleation"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmLuke Rice (University of Texas Southwestern Medical Center, USA)
"Mechanism and Regulation in Microtubule Dynamics"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Kazuhiro Oiwa (National Institute of Information and Communications Technology, Japan)
"Spontaneous Formation of a Globally Connected Contractile Network in a Microtubule-Motor System"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMotors Functioning in Organized Assemblies
Discussion Leader: Daniela Nicastro (University of Texas Southwestern Medical Center, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:50 pmDaniela Nicastro (University of Texas Southwestern Medical Center, USA)
"Cryo-Electron Tomography Provides a New Window into Ciliary Structure and Function"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDilson Rassier (McGill University, Canada)
"Load Dependence of Myosin Motors Working in Filaments and Sarcomeres"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmTarun Kapoor (The Rockefeller University, USA)
"Examining the Micro-Mechanics of 'Mini-Spindles' to Dissect Cell Division Mechanisms"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRyoma Ohi (Vanderbilt University School of Medicine, USA)
"Cellular Mechanisms that Drive Resistance to Kinesin-5 Poisons"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBuilding Complexity to Understand Cytoskeletal Function
Discussion Leader: Simon Bullock (MRC Laboratory of Molecular Biology, United Kingdom)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:20 amSimon Bullock (MRC Laboratory of Molecular Biology, United Kingdom)
"Building Complexity into Dynein-Based Cargo Transport Systems"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amSelected from Poster Abstracts: Ahmet Yildiz (University of California, Berkeley, USA)
"Cytoplasmic Dynein Is a Strong Opponent to Kinesin in a Tug-of-War"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amSelected from Poster Abstracts: Thomas Sladewski (University of Vermont, USA)
"Single-Molecule Reconstitution of a Microtubule-Based mRNA Transport Complex"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amSelected from Poster Abstracts: Ken'Ya Furuta (National Institute of Information and Communications Technology, Japan)
"Creating Novel Molecular Motors Based on Dynein and Actin-Binding Proteins"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amSelected from Poster Abstracts: Weihong Qiu (Oregon State University, USA)
"The Mitotic Kinesin-14 KlpA Contains a Context-Dependent Directionality Switch"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Ekaterina Grishchuk (Perelman School of Medicine, University of Pennsylvania, USA)
"Molecular Requirements for the Transition from Lateral to End-on Microtubule Binding and Dynamic Coupling"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Betsy McIntosh (University of Pennsylvania, USA)
"Myo1c and Endophilin Promote Kinesin-1-driven Tubulation Along Microtubules at Patterned Actin Filament Intersections"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amNikta Fakhri (Massachusetts Institute of Technology, USA)
"Self-Organization of Stress Patterns Drives State Transitions in Actin Cortices"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMohan Balasubramanian (Warwick Medical School, University of Warwick, United Kingdom)
"Cytokinesis In Vitro and In Vivo"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmTuning and Regulating Motor-Track Interactions
Discussion Leader: Kristen Verhey (University of Michigan Medical School, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:50 pmKristen Verhey (University of Michigan Medical School, USA)
"Kinesin Processivity - Alone and in Teams"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmSelected from Poster Abstracts: Adam Hendricks (McGill University, Canada)
"Dissecting Regulation by Tubulin Post-Translational Modifications, MAPs, and Network Architecture on Microtubule-Based Transport"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmAntonina Roll-Mecak (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Tubulin Tails Wag the Microtubule: Intrinsically Disordered Regions Tune Microtubule Function and Dynamics"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSelected from Poster Abstracts: Ruth Sommese (University of Minnesota, Twin Cities, USA)
"Dissecting the Regulation of Myosin Motility Through the Motor-Cargo Interface"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJonathon Howard (Yale University, USA)
"Axonemal Dynein Motor Coordination Underlying the Flagellar Beat in Chlamydomonas"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMotors Functioning in the Cellular Environment
Discussion Leader: Matthew Tyska (Vanderbilt University School of Medicine, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:20 amMatthew Tyska (Vanderbilt University School of Medicine, USA)
"A Role for Myosin-7b in Brush Border Assembly"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMagdalena Bezanilla (University of Massachusetts, USA)
"Myosin Links Microtubules to Actin Driving Persistent Polarized Growth"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amSelected from Poster Abstracts: Margaret Titus (University of Minnesota, USA)
"MyTH4-FERM Myosins Have an Ancient and Conserved Role in Filopod Initiation"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amSelected from Poster Abstracts: Ernest Heimsath (UNC School of Medicine, USA)
"Cellular and Organismal Function of Myosin-X"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Jordan Beach (National Heart, Lung, and Blood Institute, NIH, USA)
"The Sequential Amplification of Non-Muscle Myosin 2 Filaments Is Driven by MLCK, Actin Dynamics and Myosin Monomer Availability"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amGuangshuo Ou (Tsinghua University, China)
"Dissection of Intraflagellar Transport Protein Machinery Using Genome Editing Techniques in C. elegans"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Jason Stumpff (University of Vermont, USA)
"Kif18A Coordinates the Alignment and Attachment of Mitotic Chromosomes During Cell Division"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLukas Kapitein (Utrecht University, The Netherlands)
"Navigating the Cytoskeleton: Novel Tools to Dissect and Direct Intracellular Transport"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMalfunctioning Motors and Disease
Discussion Leader: Leslie Leinwand (University of Colorado Boulder, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:50 pmLeslie Leinwand (University of Colorado Boulder, USA)
"Myosin Myopathies: Pathogenesis and Potential Therapeutics"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJames Stull (University of Texas Southwestern Medical Center, USA)
"Actin-Myosin Dysfunctions and Aortic Aneurysms"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJonathan Bird (National Institute on Deafness and Other Communication Disorders, NIH, USA)
"Building Stereocilia: How Myosin Motors Shape the Actin Cytoskeleton to Detect Sound"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Jamie Stern (The University of Vermont, USA)
"Structural Dynamics of Tau on the Microtubule Surface Observed by Single-Molecule FRET"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Steven Rosenfeld (Cleveland Clinic, USA)
"Blocking Invasion Enhances Proliferation in Glioblastoma Through a Paracrine Mechanism"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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