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Extracellular Vesicles
Gordon Research Conference

Biologic Effects and Therapeutic Potential of Extracellular Vesicles

Dates

August 21-26, 2016

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chair:
Peter Quesenberry

Vice Chair:
Giovanni Camussi

Meeting Description

The 2016 Gordon Research Conference titled "Extracellular Vesicles" will present cutting edge research on the molecular, cellular and clinical translational aspects of the structure and function of extracellular vesicles and RNA. The conference will feature a wide range of topics such as vesicle isolation and characterization with an emphasis on protein content, extracellular RNA, extracellular vesicle biogenesis, vesicle cargo loading and targeting RNA, extracellular vesicles in tissue injury and repair, the role of extracellular vesicles in inflammation, extracellular vesicles in cancer, extracellular vesicles and thrombosis, extracellular vesicles in neurobiology and non-mammalian and plant extracellular vesicles. Invited speakers represent a variety of scientific and clinical disciplines including biochemistry, molecular genetics, cell biology, cardiovascular biology, hematology, oncology, pulmonary medicine, and neurobiology. The conference will bring together a collection of investigators who are at the forefront of their field and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promote cross-disciplinary collaborations in the various research areas.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Extracellular Vesicle Isolation and Vesicle Characterization (Proteins, RNA Species, Lipids)
Discussion Leader: Richard Simpson (La Trobe University, Australia)
7:40 pm - 8:10 pmEdwin van der Pol (Academic Medical Center, University of Amsterdam, The Netherlands)
"The Pathway to Single Vesicle Detection"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 9:10 pmRandy Schekman (University of California, Berkeley, USA)
"Selectivity and Mechanism of Small RNA Sorting During the Biogenesis of Exosomes"
9:10 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExtracellular RNA
Discussion Leader: David Wong (University of California, Los Angeles, USA)
9:00 am - 9:20 amEsther Nolte-'t Hoen (Utrecht University, The Netherlands)
"EV-Associated Small RNAs with Potential Regulatory Functions: miRNAs and Beyond"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNobuyoshi Kosaka (National Cancer Center Research Institute, Japan)
"The Role of Secretory miRNAs in Cancer Development"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amAndrew Hoffman (Tufts University, USA)
"Circulating Exosome miRNA in Naturally Occurring Canine Non-Ischemic Heart Diseases"
10:40 am - 10:45 amDiscussion
10:45 am - 11:05 amLeonora Balaj (Massachusetts General Hospital, USA)
"Characterization of the Extracellular Content Released from Glioblastoma Cells"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amAleksandar Milosavljevic (Baylor College of Medicine, USA)
"Community Resources from the ERCC: The exRNA Portal, the exRNA Atlas and Cloud-Hosted Tools for the Analysis of Extracellular RNA"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amElie Beit-Yannai (Ben-Gurion University of the Negev, Israel)
"Exosomes Mediated Signaling Within the Ocular Drainage System"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmReka Haraszti (University of Massachusetts Medical School, USA)
"Protein and Lipid Composition Distinguishes Stem Cell EVs from Cancer Cell EVs and Affect Efficiency of EV-Mediated Small RNA Cellular Transfer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmExtracellular Vesicle Biogenesis, Vesicle Cargo Loading and Targeting RNA
Discussion Leader: Stephen Gould (Johns Hopkins University School of Medicine, USA)
7:30 pm - 7:50 pmGraca Raposo (Institut Curie, France)
"Endosomal Sorting, Exosome Biogenesis Amyloid Formation, Communication: A View from Pigmentation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPascale Zimmermann (Centre de Recherche en Cancérologie de Marseille, France / Katholieke Universiteit Leuven, Belgium)
"Syntenin-Syndecan in the Endosomal and Exosomal Control of Cell Signalling: A Vicious Circle/Target for Cancer Medicine?"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJohn Pezacki (University of Ottawa, Canada)
"Engineered Molecular Vehicles for Small RNA Delivery"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmHarmeet Malhi (Mayo Clinic, USA)
"Hepatocytes Release Ceramide-Rich Proinflammatory Extracellular Vesicles in an IRE1Alpha-Dependent Manner"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExtracellular Vesicles in Tissue Injury and Tissue Repair
Discussion Leader: Willem Stoorvogel (Faculty of Veterinary Medicine, Utrecht University, The Netherlands)
9:00 am - 9:20 amStefania Bruno (University of Turin, Italy)
"Mesenchymal Stromal Cell-Derived Extracellular Vesicles Facilitate the Repair of Renal Injury"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJuan Sanchez-Esteban (Brown University, USA)
"Role of Extracellular Vesicles in Fetal Lung Development"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amOlin Liang (Brown University, USA)
"Extracellular Vesicles in Pulmonary Vascular Disease: Friend or Foe"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amDavid Larocca (ReCyte Therapeutics, USA)
"Exosomes from Highly Scalable and Clonally-Derived Embryonic Vascular Progenitor Cells for Therapeutic Angiogenesis"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amBernd Giebel (University of Duisburg-Essen, Germany)
"MSC-EVs, Their Way into Clinic to Treat GvHD"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amGeorge Daaboul (nanoView Diagnostics, USA)
"Microarray-Based Direct from Sample Exosome Enumeration, Sizing and Phenotyping"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMaria Brizzi (University of Turin, Italy)
"IL-3 Pro-Angiogenic Paracrine Action: Role of Stat5 Trafficking via Endothelial Cell-Derived Extracellular Vesicles"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Role of Extracellular Vesicles in Inflammation
Discussion Leader: Philip Askenase (Yale University, USA)
7:30 pm - 7:50 pmPaul Robbins (The Scripps Research Institute, USA)
"Immunoregulatory Extracellular Vesicles for Treatment of Autoimmune and Age Related Diseases"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmEdit Buzas (Semmelweis University, Hungary)
"The Role of Extracellular Vesicles in Inflammation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMargaret Alexander (University of Utah, USA)
"Immune miRNA are Functionally Transferred Between Immune Cells Altering Response to Endotoxin"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDeepak Nagrath (Rice University, USA)
"Tumor Microenvironment Derived Exosomes: A Major Player in Regulating Cancer Cell Metabolism"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNon-Mammalian and Plant Extracellular Vesicles
Discussion Leader: Meta Kuehn (Duke University Medical Center, USA)
9:00 am - 9:20 amHuang-Ge Zhang (University of Louisville, USA)
"Edible Plant Exosomes: Nanoparticles for Therapy and Targeted Delivery of Therapeutic Agents"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amLaura De La Canal (National University of Mar del Plata, Argentina)
"Biological Activities of a Vesicle-Associated Extracellular Lectin from Sunflower"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amLucia Languino (Thomas Jefferson University, USA)
"The AlphaV Integrins Are Upregulated in Prostate Cancer Patient Exosomes and Modulate Exosomal Levels of Interferon-Inducible Proteins"
10:40 am - 10:45 amDiscussion
10:45 am - 11:05 amAmy Buck (University of Edinburgh, United Kingdom)
"Vesicle and RNA Secretion by Nematode Parasites: At the Host Interface"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amCiro Tetta (Unicyte AG, Switzerland)
"Human Liver Stem Cell (HLSC)-Derived Extracellular Vesicles (EVs) Improve Argininosuccinate Synthase Genetic Deficiency"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amKenneth Witwer (Johns Hopkins University School of Medicine, USA)
"Extracellular Vesicles in HIV Production and Latency"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAkira Yokoi (National Cancer Center Research Institute, Japan)
"Malignant Extracellular Vesicles Carrying MMP1 mRNA Cause Mesothelial Exfoliation Toward Peritoneal Dissemination in Ovarian Cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmExtracellular Vesicles and Thrombosis
Discussion Leader: Benjamin Brenner (Rambam Health Care Campus, Technion - Israel Institute of Technology, Israel)
7:30 pm - 7:50 pmMary Collier (University of Leicester, United Kingdom)
"Molecular Mechanisms Regulating Tissue Factor Incorporation into Microvesicles"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNigel Mackman (University of North Carolina at Chapel Hill, USA)
"Circulating Procoagulant Microvesicles and Thrombosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRomaric Lacroix (Aix-Marseille University, France)
"Ambivalent Role of Microvesicles in Hemostasis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmLinda Rikkert (Academic Medical Center, The Netherlands)
"Strategies to Identify Rare Extracellular Vesicles in Human Body Fluids"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmExtracellular Vesicles in Neurobiology
Discussion Leader: Neha Raukar (Brown University, USA)
9:00 am - 9:20 amFred Hochberg (University of California, San Diego, USA)
"Cerebrospinal Fluid Analyses of exRNA"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRichard Kraig (University of Chicago, USA)
"Exosomes and Environmental Enrichment-Based Neurotherapeutics"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amMichael Chopp (Henry Ford Hospital, USA)
"Treatment of Neural Injury with Exosomes Promotes Neurovascular Remodeling and Functional Recovery"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amStacey Gifford (IBM Research, USA)
"A Novel Method for Exosome Separation: nanoDLD Chip Technology"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amClaudia Verderio (Institute of Neuroscience, National Research Council (CNR), Italy)
"Multimodal Microglial Modulation of Neuronal Functions Through Extracellular Vesicles"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmRandolph Corteling (ReNeuron Limited, United Kingdom)
"The Development of Neural Stem Cell Exosomes for Clinical Applications"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShannon Pendergrast (Ymir Genomics LLC, USA)
"Enabling Urine Extra-Cellular Biomarker Discovery"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmExtracellular Vesicles in Cancer
Discussion Leader: Clotilde Thery (Institut Curie, France)
5:30 pm - 5:50 pmPeter Kurre (Oregon Health and Science University, USA)
"The Role of Extracellular Vesicles in the Hematopoietic Microenvironment"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmJohan Skog (Exosome Diagnostics, USA)
"Exosome Biomarkers, Current State and Future Directions"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmRaghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"The Biology and Function of Cancer Exosomes"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmSicheng Wen (Rhode Island Hospital / Brown University, USA)
"Mesenchymal Stromal Cell Derived Extracellular Vesicles Rescue Radiation Damage to Murine Marrow Hematopoietic Cells"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

The views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other documentation.

Funding for this conference was made possible (in part) by 1 R13 TR001583-01 from the National Center for Advancing Translational Sciences (NCATS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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