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Nasopharyngeal Carcinoma
Gordon Research Conference

Global Lessons on Cancer Pathogenesis from Insights into a Geographically Restricted Tumor of the Nasopharynx

Dates

June 26 - July 1, 2016

Location

The Hong Kong University of Science and Technology
Hong Kong, China

Organizers

Chairs:
Maria Lung & Lawrence Young

Vice Chairs:
George S. Tsao & Fei-Fei Liu

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Meeting Description

Nasopharyngeal carcinoma (NPC) is a deadly cancer arising in the nasopharynx and has its highest incidence worldwide in Southern Asians. The etiology of this unique cancer includes three co-factors that include host genetics, Epstein-Barr Virus (EBV) infection, and environmental factors. How these factors contribute to the development of this cancer provide important lessons for understanding tumor pathogenesis.

This conference brings together experts spanning the fields of cancer biology and virology, genetics, epidemiology, translational medicine, and novel therapeutic approaches. It will provide a unique opportunity to consider how an understanding of basic mechanisms can be translated into innovative diagnosis and treatment.

Sessions will be led by world-leading plenary speakers, who will provide oversight lectures covering areas such as cancer genomics, carcinogenesis, DNA repair, novel diagnostic biomarkers, and innovative therapies. These lectures will set the scene for more specific consideration of NPC and provide opportunities for detailed discussion and constructive interactions.

Contributors

Final Meeting Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCancer: Viruses and Signaling
Discussion Leader: Alan Rickinson (University of Birmingham, United Kingdom)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:25 pmHarald zur Hausen (German Cancer Research Center, Germany)
"Discovery and Early Studies of EBV in Burkitt's Lymphoma and NPC"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmHans Clevers (Hubrecht Institute, The Netherlands)
"Wnt Signaling and Cancer"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer Genomics
Discussion Leader: Yu Sun Chang (Chang Gung University, Taiwan)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amAndrew Futreal (University of Texas MD Anderson Cancer Center, USA)
"Cancer Genomics and Evolution"
9:45 am - 10:05 amDiscussion
10:05 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amJin-Xin Bei (Sun Yat-Sen University Cancer Center, China)
"Genetic Basis of Nasopharyngeal Carcinoma"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amHong Zheng (The University of Hong Kong, Hong Kong SAR China)
"Identification of Genetic Susceptibility Genes in Nasopharyngeal Carcinoma by Next-Generation Sequencing"
11:20 am - 11:30 amDiscussion
11:30 am - 12:10 pmKwok Wai Lo (The Chinese University of Hong Kong, Hong Kong SAR China)
"NPC Genetics: Progressive Genomic Changes"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Fei-Fei Liu (Princess Margaret Hospital, Canada) and Anne Lee (The University of Hong Kong, Hong Kong SAR China)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLessons from an Epithelial Cancer
Discussion Leader: Ingemar Ernberg (Karolinska Institute, Sweden)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:15 pmElaine Fuchs (The Rockefeller University, USA)
"Transition of Normal Epithelia to Cancer"
8:15 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMu Sheng Zeng (Sun Yat-Sen University Cancer Center, China)
"NPC, an Epithelial Cancer: Immortalization and Tumorigenesis"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEBV Genetics and Biology
Discussion Leader: Lori Frappier (University of Toronto, Canada)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amHenri-Jacques Delecluse (DKFZ - German Cancer Research Center, Germany)
"Is NPC Caused by a Particular EBV?"
9:45 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:30 am - 11:10 amRichard Longnecker (Northwestern University, USA)
"EBV Entry into Host"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmGeorge Tsao (University of Hong Kong, Hong Kong SAR China)
"Establishment of New NPC Xenografts and Cell Lines for EBV Studies"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmRisk Factors and Cancer
Discussion Leader: Eric Stanbridge (University of California, Irvine, USA)
4:00 pm - 4:05 pmIntroduction by Discussion Leader
4:05 pm - 4:45 pmXin Lu (Ludwig Institute for Cancer Research, United Kingdom)
"p53, a Key Regulator of Genomic Stability in Cancer"
4:45 pm - 5:05 pmDiscussion
5:05 pm - 5:45 pmAllan Hildesheim (National Cancer Institute, NIH, USA)
"Use of Viral and Genetic Markers for Risk Stratification for Development of Screening Programs for the Early Detection of NPC"
5:45 pm - 6:00 pmDiscussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNPC Diagnostic Biomarkers
Discussion Leader: Pierre Busson (Institut Gustave Roussy, France)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amFei-Fei Liu (Princess Margaret Hospital, Canada)
"Prognostic Significance of miRNA Signatures for Detection of Metastatic NPC"
9:45 am - 10:05 amDiscussion
10:05 am - 10:25 amHonglin Chen (University of Hong Kong, Hong Kong SAR China)
"EBV BART miRNA and Serological Biomarkers for NPC"
10:25 am - 10:35 amDiscussion
10:35 am - 11:00 amCoffee Break
11:00 am - 11:40 amDennis Lo (Chinese University of Hong Kong, Hong Kong SAR China)
"Plasma DNA Analysis for Detecting NPC: Biological Insights and Clinical Applications"
11:40 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmWei Dai (The University of Hong Kong, Hong Kong SAR China)
"Methylation Biomarkers in NPC"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmChallenges for Primary Treatment of NPC
Discussion Leader: Anne Lee (The University of Hong Kong, Hong Kong SAR China)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:10 pmBrian O'Sullivan (University of Toronto, Canada)
"Challenges for Radiotherapy Treatment of NPC"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmRoger Ngan (Queen Elizabeth Hospital, Hong Kong SAR China)
"Evolution of NPC Clinical Trials in Hong Kong"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJun Ma (Sun Yat-Sen Medical University, China)
"NPC Clinical Trials in Guangzhou"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInnovative Therapies for NPC / Selected Poster Presentations
Discussion Leader: Rajiv Khanna (QIMR Berghofer Medical Research Institute, Australia)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amCliona Rooney (Baylor College of Medicine, USA)
"Cancer Immunotherapy and Challenges for NPC"
9:45 am - 10:05 amDiscussion
10:05 am - 10:30 amBrigette Ma (Chinese University of Hong Kong, Hong Kong SAR China)
"Novel Targets for NPC Treatment"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amWilliam Wei (Hong Kong Sanatorium & Hospital, Hong Kong SAR China)
"Challenges for Surgical Management of Recurrent NPC"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amRaymond Ng (University of Toronto, Canada)
"Detection and Screening for NPC with Trans-Oral Brushing and Determination of EBV DNA"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTroy Messick (The Wistar Institute, USA)
"Development of Small Molecule Inhibitors of EBNA1 for the Treatment of Nasopharyngeal Carcinoma"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMhairi Morris (Faculty of Health and Life Sciences, De Montfort University, United Kingdom)
"EBV-Encoded LMP1 Induces a Myofibroblast-Like Phenotype in Epithelial Cells via Epithelial-to-Mesenchymal Transition"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmFuture Prospects for NPC
Discussion Leader: Lawrence Young (University of Warwick, United Kingdom)
4:00 pm - 4:10 pmIntroduction by Discussion Leader
4:10 pm - 4:50 pmAlan Rickinson (University of Birmingham, United Kingdom)
"Future Focus for Basic NPC and EBV Studies"
4:50 pm - 5:05 pmDiscussion
5:05 pm - 5:45 pmQuynh Le (Stanford University, USA)
"Future Personalised Clinical Care for NPC Patients"
5:45 pm - 6:00 pmDiscussion
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA206183-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Any opinions, findings, conclusions or recommendations expressed in this material/event (or by members of the project team) do not reflect the views of the Government of the Hong Kong Special Administrative Region, the Innovation and Technology Commission or the Vetting Committee of the General Support Programme of the Innovation and Technology Fund.
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